Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387246652> ?p ?o ?g. }
- W4387246652 abstract "ABSTRACT Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors driven by complex driver mutations and glioma stem cells (GSCs). The neurodevelopmental transcription factors ASCL1 and OLIG2 are co-expressed in GBMs, but their role in regulating the heterogeneity and hierarchy of GBM tumor cells is unclear. Here, we show that oncogenic driver mutations lead to dysregulation of ASCL1 and OLIG2, which function redundantly to initiate brain tumor formation in a mouse model of GBM. Subsequently, the dynamic levels and reciprocal binding of ASCL1 and OLIG2 to each other and to downstream target genes then determine the cell types and degree of migration of tumor cells. Single-cell RNA sequencing (scRNA-seq) reveals that a high level of ASCL1 is key in defining GSCs by upregulating a collection of ribosomal protein, mitochondrial, neural stem cell (NSC), and cancer metastasis genes – all essential for sustaining the high proliferation, migration, and therapeutic resistance of GSCs." @default.
- W4387246652 created "2023-10-03" @default.
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- W4387246652 date "2023-10-02" @default.
- W4387246652 modified "2023-10-10" @default.
- W4387246652 title "Glioblastoma initiation, migration, and cell types are regulated by core bHLH transcription factors ASCL1 and OLIG2" @default.
- W4387246652 cites W1541324451 @default.
- W4387246652 cites W1560976558 @default.
- W4387246652 cites W1592749693 @default.
- W4387246652 cites W1666901150 @default.
- W4387246652 cites W1868000512 @default.
- W4387246652 cites W1896744632 @default.
- W4387246652 cites W1934209312 @default.
- W4387246652 cites W1976633761 @default.
- W4387246652 cites W1979594866 @default.
- W4387246652 cites W1986004489 @default.
- W4387246652 cites W1988986134 @default.
- W4387246652 cites W1998766660 @default.
- W4387246652 cites W2004471993 @default.
- W4387246652 cites W2019433791 @default.
- W4387246652 cites W2025509503 @default.
- W4387246652 cites W2027303624 @default.
- W4387246652 cites W2028117656 @default.
- W4387246652 cites W2030017878 @default.
- W4387246652 cites W2030996065 @default.
- W4387246652 cites W2036870885 @default.
- W4387246652 cites W2039458547 @default.
- W4387246652 cites W2039879202 @default.
- W4387246652 cites W2040458067 @default.
- W4387246652 cites W2049082108 @default.
- W4387246652 cites W2050645792 @default.
- W4387246652 cites W2054275187 @default.
- W4387246652 cites W2056404556 @default.
- W4387246652 cites W2064847009 @default.
- W4387246652 cites W2065970275 @default.
- W4387246652 cites W2069089843 @default.
- W4387246652 cites W2069187984 @default.
- W4387246652 cites W2078510083 @default.
- W4387246652 cites W2082631547 @default.
- W4387246652 cites W2096287682 @default.
- W4387246652 cites W2109816625 @default.
- W4387246652 cites W2115762984 @default.
- W4387246652 cites W2115894077 @default.
- W4387246652 cites W2119152345 @default.
- W4387246652 cites W2128464557 @default.
- W4387246652 cites W2136051820 @default.
- W4387246652 cites W2136541538 @default.
- W4387246652 cites W2143455626 @default.
- W4387246652 cites W2146517909 @default.
- W4387246652 cites W2147091956 @default.
- W4387246652 cites W2147673571 @default.
- W4387246652 cites W2155082284 @default.
- W4387246652 cites W2158585209 @default.
- W4387246652 cites W2161289668 @default.
- W4387246652 cites W2164258210 @default.
- W4387246652 cites W2168414172 @default.
- W4387246652 cites W2170461655 @default.
- W4387246652 cites W2170551349 @default.
- W4387246652 cites W2172520832 @default.
- W4387246652 cites W2190545194 @default.
- W4387246652 cites W2233396230 @default.
- W4387246652 cites W2245482469 @default.
- W4387246652 cites W2345641371 @default.
- W4387246652 cites W2406250479 @default.
- W4387246652 cites W2415341492 @default.
- W4387246652 cites W2520705953 @default.
- W4387246652 cites W2580293709 @default.
- W4387246652 cites W2598348504 @default.
- W4387246652 cites W2606762119 @default.
- W4387246652 cites W2736042082 @default.
- W4387246652 cites W2752214746 @default.
- W4387246652 cites W2755975022 @default.
- W4387246652 cites W2799466292 @default.
- W4387246652 cites W2887204823 @default.
- W4387246652 cites W2898477289 @default.
- W4387246652 cites W2905064718 @default.
- W4387246652 cites W2920905077 @default.
- W4387246652 cites W2921650721 @default.
- W4387246652 cites W2936068176 @default.
- W4387246652 cites W2944043725 @default.
- W4387246652 cites W2951158909 @default.
- W4387246652 cites W2951880440 @default.
- W4387246652 cites W2953124982 @default.
- W4387246652 cites W2961217357 @default.
- W4387246652 cites W2994745478 @default.
- W4387246652 cites W2997280954 @default.
- W4387246652 cites W2997690955 @default.