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- W4387246760 abstract "Abstract The prothoracicotropic hormone (Ptth) is well-known for its important role in controlling insect developmental timing and body size by promoting the biosynthesis and release of ecdysone. However, the role of Ptth in adult physiology is largely unexplored. Here we show that Ptth null mutants (both males and females) show extended lifespan and healthspan, and exhibit increased resistance to oxidative stress. Transcriptomic analysis reveals that age-dependent upregulation of innate immunity pathway is attenuated by Ptth mutants. Intriguingly, we find that Ptth regulates the innate immunity pathway, specifically in fly oenocytes, the homology of mammalian hepatocytes. We further show that oenocyte-specific overexpression of Relish shortens the lifespan, while oenocyte-specific downregulation of ecdysone signaling extends lifespan. Consistently, knocking down torso , the receptor of Ptth in the prothoracic gland also promotes longevity of the flies. Thus, our data reveal a novel function of the insect hormone Ptth in longevity regulation and innate immunity in adult Drosophila . Significance The function of Ptth is heavily studied in the insect development stage, especially molting and metamorphosis. However, we know very little about the role of Ptth in adult physiology. In this study, we find that Ptth regulates lifespan through the regulation of the innate immunity pathway in a tissue-specific manner in Drosophila . Similar to mammalian growth hormone, Ptth might be the key growth factor that controls longevity by targeting liver inflammation." @default.
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- W4387246760 date "2023-10-02" @default.
- W4387246760 modified "2023-10-10" @default.
- W4387246760 title "Ptth regulates lifespan through innate immunity pathway in Drosophila" @default.
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- W4387246760 doi "https://doi.org/10.1101/2023.09.30.560323" @default.
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