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• W4387247941 abstract "SESSION TITLE: Pharmacotherapeutics Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2023 12:00 pm - 12:45 pm PURPOSE: MDIs are the most common type of inhaler in North America and an important device option for many respiratory patients. The addition of a spacer can improve lung deposition, overcome coordination issues and reduce side effects caused by oropharyngeal deposition. The objective of this assessment was to evaluate the general impact of treating patients with a MDI/Spacer delivery system rather than MDI alone, using literature search and scenario modelling. METHODS: A literature search was undertaken to identify published pharmacokinetic (PK) studies in which lung delivery data was generated directly comparing MDI and MDI/Spacer systems, the aim being to assess the relationship and determine the average ratio. Based upon the observed relationship, modelled impact assessments were generated for both reliever and controller MDIs in terms of a) patient / clinical, b) health care system and c) environment. RESULTS: Three published pharmacokinetic (PK) studies were identified using current MDIs, all of which reported direct comparisons between MDI and MDI/Spacer (AeroChamber Plus* brand) lung delivery. Focusing on the AUC data, it was observed that the mean MDI deliveries to the lungs (as percentage of mean delivery for MDI/Spacer combination) were 35%, 39% and 70%. As such, a grouped average of 48% (or a 2x increase if viewed as MDI to MDI/VHC) was used for the impact assessments. For Reliever MDIs it was modelled that the potential impact of switching MDI to MDI/Spacer for patient was quicker relief of symptoms, for health care system was up to a 50% saving in the cost of MDIs, and for the environment was up to 50% reduction in carbon emissions. For Controller MDIs it was modelled that the potential impact of switching MDI to MDI/Spacer for patient was better disease control and management of symptoms plus less ICS related side effects, for health care system was savings due to less step ups in dose and less hospitalizations, and for environment was no change or reduction in carbon emissions if patient was on MART therapy. CONCLUSIONS: For subjects with perfect inhaler coordination, the PK studies showed it was possible to achieve similar lung delivery using MDI alone compared to MDI with spacer, however not many people had perfect coordination as on average the MDI alone delivery to the lungs was only 48% for MDI alone users (compared to with Spacer). In the modelled impact assessment such a difference translated to significant potential benefits to the patient, health care system and environment when moving to a MDI/Spacer delivery system. CLINICAL IMPLICATIONS: It is recognized that there is some variability between different MDIs, not everyone may use a spacer and that there are alternative inhaler delivery systems to consider, however, based upon the improved lung delivery outcomes, there is compelling evidence to consider the broader use of spacers in the global patient population. DISCLOSURES: Employee relationship with Trudell Medical International Please note: >$100000 by Jason Suggett, value=Salary" @default.
• W4387247941 created "2023-10-03" @default.
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• W4387247941 date "2023-10-01" @default.
• W4387247941 modified "2023-10-03" @default.
• W4387247941 title "ASSESSMENT OF METERED DOSE INHALER (MDI) VS MDI AND SPACER–IMPACT ON PATIENT, HEALTH CARE SYSTEM, AND THE ENVIRONMENT" @default.
• W4387247941 doi "https://doi.org/10.1016/j.chest.2023.07.3374" @default.
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