FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387247961> ?p ?o ?g. }

• W4387247961 endingPage "A4484" @default.
• W4387247961 startingPage "A4484" @default.
• W4387247961 abstract "SESSION TITLE: Lung Cancer Case Report Posters 6 SESSION TYPE: Case Report Posters PRESENTED ON: 10/09/2023 12:00 pm - 12:45 pm INTRODUCTION: Thromboembolic events are a known consequence of cancer and may manifest as various clinical syndromes. This case describes a man with a recent history of pulmonary emboli who was admitted for an NSTEMI and ultimately diagnosed with nonbacterial thrombotic endocarditis (NBTE) as well as lung adenocarcinoma. It highlights unique presentations of a hypercoagulable state and a broad differential for a cavitary lung lesion with its mimicking conditions. CASE PRESENTATION: A 44-year-old male from Armenia presented to an outside hospital with shortness of breath and was diagnosed with multiple pulmonary emboli on chest CTA. Three months later, the patient re-presented to the ER for severe right-sided chest pain. He had increasing troponin levels and underwent a cardiac ischemic workup. His echocardiogram revealed an irregular-shaped, echodensity on the atrial side of the mitral valve. A coronary angiogram revealed significant distal tapering of the LAD, concerning for distal emboli from the mitral valve vegetation. Interval CT chest also showed a 3.8 x 2.7cm mass in the right upper lobe with cavitation. On infectious workup, one AFB-sputum culture grew positive and resulted in MAC. His other two AFB cultures were negative, and the MTB PCRs were negative. The remainder of his workup to rule out other bacterial and fungal etiologies were negative, and blood cultures remained negative, making NBTE the most likely etiology of his mitral valve mass. A CT-guided biopsy of the lung lesion revealed moderately differentiated adenocarcinoma. Thereafter, he had several readmissions for arterial embolic events including NSTEMI, ischemic stroke, and acute limb ischemia requiring emergent endarterectomy, all of which likely occurred from his mitral valve endocarditis. Pathology from the endarterectomy confirmed bland thrombus. DISCUSSION: Our patient presented with numerous sequelae from hypercoagulability prior to the ultimate diagnosis of lung adenocarcinoma. Our case additionally highlights that malignancy can often mimic infectious etiologies. While pulmonary embolism represents a common presentation of occult malignancy, NBTE is much rarer. Systemic emboli occur in nearly half of patients with NBTE, which our patient developed later in his clinical course as well [1,2] This patient's presentation was particularly unique: an NSTEMI caused by embolization stemming from NBTE. The angiographic appearance with distal tapering was most consistent with septic emboli, particularly in the context of the mitral valve mass identified on echocardiogram. Coronary artery embolization causing myocardial infarction is a less common complication of NBTE that only a few case reports describe. CONCLUSIONS: Occult malignancy is associated with a hypercoagulable state, which can result in rare clinical manifestations including NBTE and the various consequences of systemic emboli. REFERENCE #1: Itzhaki Ben Zadok O, Spectre G, Leader A. Cancer-associated non-bacterial thrombotic endocarditis. Thromb Res. 2022;213 Suppl 1:S127-S132. doi:10.1016/j.thromres.2021.11.024 REFERENCE #2: el-Shami K, Griffiths E, Streiff M. Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment. Oncologist. 2007;12(5):518-523. doi:10.1634/theoncologist.12-5-518 REFERENCE #3: Lee V, Gilbert JD, Byard RW. Marantic endocarditis - A not so benign entity. J Forensic Leg Med. 2012;19(6):312-315. doi:10.1016/j.jflm.2012.02.021 DISCLOSURES: No relevant relationships by Hector Filizola No relevant relationships by Patrick Poquiz No relevant relationships by Kristin Schwab" @default.
• W4387247961 created "2023-10-03" @default.
• W4387247961 creator A5058473697 @default.
• W4387247961 creator A5062339766 @default.
• W4387247961 creator A5075794299 @default.
• W4387247961 date "2023-10-01" @default.
• W4387247961 modified "2023-10-03" @default.
• W4387247961 title "PULMONARY EMBOLI, NONBACTERIAL THROMBOTIC ENDOCARDITIS, AND NSTEMI: A UNIQUE PRESENTATION OF LUNG ADENOCARCINOMA" @default.
• W4387247961 doi "https://doi.org/10.1016/j.chest.2023.07.2912" @default.
• W4387247961 hasPublicationYear "2023" @default.
• W4387247961 type Work @default.
• W4387247961 citedByCount "0" @default.
• W4387247961 crossrefType "journal-article" @default.
• W4387247961 hasAuthorship W4387247961A5058473697 @default.
• W4387247961 hasAuthorship W4387247961A5062339766 @default.
• W4387247961 hasAuthorship W4387247961A5075794299 @default.
• W4387247961 hasBestOaLocation W43872479611 @default.
• W4387247961 hasConcept C126322002 @default.
• W4387247961 hasConcept C126838900 @default.
• W4387247961 hasConcept C137627325 @default.
• W4387247961 hasConcept C141071460 @default.
• W4387247961 hasConcept C164705383 @default.
• W4387247961 hasConcept C2775872228 @default.
• W4387247961 hasConcept C2776256026 @default.
• W4387247961 hasConcept C2777543888 @default.
• W4387247961 hasConcept C2777693794 @default.
• W4387247961 hasConcept C2777714996 @default.
• W4387247961 hasConcept C2778704086 @default.
• W4387247961 hasConcept C2910003292 @default.
• W4387247961 hasConcept C71924100 @default.
• W4387247961 hasConceptScore W4387247961C126322002 @default.
• W4387247961 hasConceptScore W4387247961C126838900 @default.
• W4387247961 hasConceptScore W4387247961C137627325 @default.
• W4387247961 hasConceptScore W4387247961C141071460 @default.
• W4387247961 hasConceptScore W4387247961C164705383 @default.
• W4387247961 hasConceptScore W4387247961C2775872228 @default.
• W4387247961 hasConceptScore W4387247961C2776256026 @default.
• W4387247961 hasConceptScore W4387247961C2777543888 @default.
• W4387247961 hasConceptScore W4387247961C2777693794 @default.
• W4387247961 hasConceptScore W4387247961C2777714996 @default.
• W4387247961 hasConceptScore W4387247961C2778704086 @default.
• W4387247961 hasConceptScore W4387247961C2910003292 @default.
• W4387247961 hasConceptScore W4387247961C71924100 @default.
• W4387247961 hasIssue "4" @default.
• W4387247961 hasLocation W43872479611 @default.
• W4387247961 hasOpenAccess W4387247961 @default.
• W4387247961 hasPrimaryLocation W43872479611 @default.
• W4387247961 hasRelatedWork W1540457149 @default.
• W4387247961 hasRelatedWork W1970507324 @default.
• W4387247961 hasRelatedWork W1988485352 @default.
• W4387247961 hasRelatedWork W2104672721 @default.
• W4387247961 hasRelatedWork W2309981611 @default.
• W4387247961 hasRelatedWork W2331364821 @default.
• W4387247961 hasRelatedWork W2360476795 @default.
• W4387247961 hasRelatedWork W2418060784 @default.
• W4387247961 hasRelatedWork W4200597824 @default.
• W4387247961 hasRelatedWork W4280637722 @default.
• W4387247961 hasVolume "164" @default.
• W4387247961 isParatext "false" @default.
• W4387247961 isRetracted "false" @default.
• W4387247961 workType "article" @default.