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• W4387248952 abstract "SESSION TITLE: Asthma Treatment and Longitudinal Studies SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/09/2023 12:00 pm - 12:45 pm PURPOSE: The ability to provide rapid inhaled bronchodilator therapy by nebulizer is important for quick relief of obstructive airway symptoms in emergency care and the general hospital environment. In situations where breath actuated delivery of nebulized medication is not available, constant output jet nebulizers are routinely used. This study compared three commonly used continuous jet nebulizers in US hospitals and assessed the drug delivery and speed of delivery. METHODS: Devices tested were MC 300 (Monaghan Medical), Misty Max 10 (AirLife) and Misty Fast (AirLife). Each nebulizer group (n=5) was operated with compressed wall air set to 8 L/min and with a 3-mL fill volume (833 µg/mL albuterol sulfate). A breathing simulator was set to mimick adult (and child) tidal breathing patterns: tidal volume = 500 (155) cc, rate/min = 10 (25) cycles, inspiratory: expiratory ratio =1:2. A filter was replaced minute-by-minute at the mouthpiece to capture the total mass until sputter (TM), sputter being considered representative of treatment time. Albuterol recovered was quantified by UV-spectrophotometry. In parallel, respirable droplet fraction <4.7 mm (RDF<4.7 mcm) was determined by laser diffractometry. The clinically relevant respirable droplet mass (RDM<4.7 mcm) was calculated as TM x RDF<4.7 mcm and represented as mean and SD in the results. RESULTS: The MC 300 nebulizer produced RDM<4.7 mm values of 185.7mcg ± 10.2 and 304.0mcg ± 32.3 for the child and adult breathing patterns respectively. In comparison, the Misty Max 10 produced 171.3mcg ± 6.9 and 227.0mcg ± 50.1, and the Misty Fast produced 125.6mcg ± 4.8 and 182.1mcg ± 23.7 The treatment times to sputter for the MC 300 and Misty Fast devices both ranged from 3 to 4 mins whereas the Misty Max 10 ranged from 4 to 5 mins. CONCLUSIONS: The MC 300 nebulizer produced the highest respirable doses (for both adult and child breathing patterns) and the equal best (with Misty Fast) speed of delivery. The Misty Max 10 device was second in terms of drug delivery but had longest delivery time. CLINICAL IMPLICATIONS: These results provide clinicians with data to support an informed selection of nebulizer in cases where the goal of maximizing lung delivery with shortest treatment time is desired. DISCLOSURES: Employee relationship with Monaghan Medical Please note: 1995 to present Added 07/05/2023 by Dominic Coppolo, source=Web Response, value=Salary Employee relationship with Trudell Medical International Please note: 29 years Added 03/24/2023 by Mark Nagel, value=Salary Employee relationship with Monaghan Medical Corporation Please note: 2019-2023 Added 04/05/2023 by Judy Schloss, source=Web Response, value=Salary Employee relationship with Trudell Medical International Please note: >$100000 by Jason Suggett, value=Salary" @default.
• W4387248952 created "2023-10-03" @default.
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• W4387248952 date "2023-10-01" @default.
• W4387248952 modified "2023-10-03" @default.
• W4387248952 title "LABORATORY ASSESSMENT (FINE PARTICLE MASS AND RUN TIMES) OF THREE CONSTANT OUTPUT NEBULIZERS: HOW TO OPTIMIZE DRUG DELIVERY AND TREATMENT TIME FOR THIS TYPE OF DEVICE" @default.
• W4387248952 doi "https://doi.org/10.1016/j.chest.2023.07.3375" @default.
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