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• W4387249570 abstract "SESSION TITLE: Pulmonary Vascular Disease Posters 1 SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2023 12:00 pm - 12:45 pm PURPOSE: Pulmonary hypertension (PH) is often caused by long standing valvular heart disease and is associated with increased mortality after mitral valve surgery for mitral regurgitation. Transcatheter mitral valve repair (TMVR) has emerged as an alternative therapeutic intervention for patients deemed high risk for surgical mitral valve repair or replacement. Limited data is available regarding the clinical outcomes after TMVR using the MitraClip system. Thus, we conducted this study to assess the 30-day readmission and in-hospital outcomes of patients with PH following MitraClip procedure. METHODS: Using the all-payer, nationally representative Nationwide Readmissions Database, our study included patients aged 18 years or older who underwent TMVR with MitraClip between 2017 and 2020. We then analyzed the in-hospital procedural outcome and 30-day readmission between the patients with and without PH. RESULTS: Our study includes a total of 18,563 patients who underwent TMVR with MitraClip between 2017 and 2020. Amongst, 5580 patients (30.1%) had PH. Following the TMVR with MitraClip procedure, compared to patients without comorbid PH, patients with PH had significantly higher rates of prolonged length of hospital stay (≥7 days) (27.83% vs 11.96%, OR 1.27, p <0.01), 30-day readmission (15.58% vs 13.72%, OR 1.16, p<0.01), and early mortality (3.80% vs 2.83%, OR 1.58, p<0.01). In terms of procedural complications, patients with PH also had higher rates of vascular complications (8.73% vs 7.09%, OR 1.25, p<0.01), major bleeding requiring transfusion (2.83% vs 2.04%, OR 1.4, p<0.01) and acute kidney injury (AKI) (22.67% vs 12.09%, OR 1.98, p<0.01). There was no significant difference in stroke (1.16% vs 1.13%, OR 1.03, p=0.85) and hemopericardium or cardiac tamponade (0.50% vs 0.52%, OR 0.97, p=0.90) between two groups. CONCLUSIONS: Patients with PH who underwent TMVR with MitraClip had poorer in-hospital outcomes compared to those without PH. Vascular complications, major bleeding requiring transfusion and AKI were more prevalent in patients with PH post-procedurally. This highlights the importance of close monitoring and meticulous post-procedural management among patients with PH. CLINICAL IMPLICATIONS: This study focuses on understanding the prognostic significance of PH in patients who undergo TMVR with MitraClip and highlights the improtance of early intervention in patients with severe MR. DISCLOSURES: No relevant relationships by Ruhma Ali No relevant relationships by Qi Xuan Ang No relevant relationships by claudia komer No relevant relationships by Richard Miller No relevant relationships by Aditya Patel No relevant relationships by Min Choon Tan" @default.
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• W4387249570 date "2023-10-01" @default.
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• W4387249570 title "IMPACT OF PULMONARY HYPERTENSION ON TRANSCATHETER MITRAL VALVE REPAIR WITH MITRACLIP: AN INSIGHT FROM NATIONAL READMISSION DATABASE FROM 2017-2020" @default.
• W4387249570 doi "https://doi.org/10.1016/j.chest.2023.07.3796" @default.
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