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• W4387250221 abstract "SESSION TITLE: New Insights Into Management of Obstructive Lung Disease SESSION TYPE: Original Investigations PRESENTED ON: 10/08/2023 08:15 am - 09:15 am PURPOSE: Asthma is a chronic inflammatory disease of the airways associated with airway hyperresponsiveness. Management of moderate to severe persistent asthma can be challenging. The therapeutic approach to asthma management has undergone a paradigm change with the introduction of biologics. These medications have significantly reduced healthcare utilization, the number of asthma exacerbations, and improved overall quality of life. However, the impact of biologics on hospital outcomes among patients admitted for asthma exacerbation has not been studied. Our study's primary objective was to determine biologics' impact on outcomes of asthma exacerbation in hospitalized patients. Our secondary objective is to determine if racial and gender disparities exist in biologics prescription. METHODS: It is a 5-year retrospective data analysis of patients with moderate and severe persistent asthma using Slicer-Dicer, a self-service cohort exploration tool embedded in EPIC from February 15, 2018, to February 15, 2023, at a Mid-west tertiary care teaching hospital. Amongst these, patients getting admitted for asthma exacerbation were categorized into biologics and the control group. The primary outcome was the incidence of asthma exacerbation needing hospital and intensive care unit admission, invasive ventilation, and the overall hospital length of stay. The secondary outcome was the prescription of biologics in patients diagnosed with moderate and severe persistent asthma. The chi-square test was used to compare the two groups and to assess if an association of race and gender exists with biologic therapy prescription. RESULTS: A total of 9961 patients (males - 36% Caucasians – 74.5%) with moderate and severe persistent asthma were registered with our hospital from February 15, 2018, to February 15, 2023, of which 316 patients (3.1%) were on biologics. Of the total patients, females were more likely to be on biologics than males (3.4% vs 2.6%, p-0.03). No racial disparities were observed. Patients on biologics had a significantly lower incidence of asthma exacerbation needing hospital admissions. (0.9% vs 6.5%, p-0.00006). The rate of ICU admission was also lower amongst patients on biologics (0.3% vs 1.8%, p – 0.04). No patients in the biologic group required mechanical ventilation compared to 36 patients in the non-biologic group. The overall hospital length of stay was similar in both groups. CONCLUSIONS: In this population-based electronic data analysis study, biologics were associated with a lower incidence of asthma exacerbation needing hospitalization, ICU admission, and mechanical ventilation. Our review suggests no racial disparities exist in the prescription of biologics in our population. CLINICAL IMPLICATIONS: A low threshold in initiating biologic therapy in moderate and severe persistent asthma can reduce morbidity associated with asthma exacerbation necessitating hospitalization. DISCLOSURES: No relevant relationships by Prabina Ghimire No relevant relationships by Sushan Gupta No relevant relationships by Avani Mohta No relevant relationships by Danish Thameem" @default.
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• W4387250221 date "2023-10-01" @default.
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• W4387250221 title "RETROSPECTIVE ANALYSIS COMPARING THE IMPACT OF BIOLOGICS VERSUS STANDARD THERAPY IN PATIENTS HOSPITALIZED FOR ASTHMA EXACERBATION" @default.
• W4387250221 doi "https://doi.org/10.1016/j.chest.2023.07.3194" @default.
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