FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387252803> ?p ?o ?g. }

• W4387252803 abstract "Abstract Patients with ampulla of Vater adenocarcinoma exhibit diverse outcomes, likely since these malignancies can originate from any of the three converging epithelia at this site. Such variability presents difficulties in clinical decision-making processes and in devising therapeutic approaches. In this study, the potential clinical value of histomolecular phenotypes was determined by integrating histopathological analysis with protein expression (MUC1, CDX2, CK20, and MUC2), in a cohort of 87 patients diagnosed with stage IB to III ampulla of Vater adenocarcinoma who underwent curative surgical resection. Of the 87 patients, 54 were classified as pancreato-biliary (PB) subtype and 33 as intestinal subtype. The median follow-up time for all patients was 32.8 months (95% CI, 25.3–49.2). Patients with a histomolecular PB phenotype (CDX2 negative, MUC1 positive, MUC2 negative, and irrespective of the CK20 results) were associated with poor prognostic outcomes in both disease-free survival (DFS) (HR = 1.81; 95% CI, 1.04–3.17; p = 0.054) and overall survival (OS) (HR = 2.01; 95% CI, 1.11–3.66; p = 0.039) compared to those with histomolecular intestinal carcinomas. Patients with the PB subtype were more likely to have local recurrence alone (11 of 37, 29.7%) compared to those with the intestinal subtype (1 of 15, 6.7%). In the context of systemic disease, a notably greater proportion of patients exhibiting elevated carbohydrate antigen 19–9 levels were observed in the PB subtype compared to the intestinal subtype ( p = 0.024). In the cohort of 38 patients who received first-line palliative chemotherapy, a diminished median overall survival (OS) was observed in the PB group compared to the intestinal group (10.3 vs. 28.3 months, HR = 2.47; 95% CI, 1.23–4.95; p = 0.025). By integrating histopathologic and molecular criteria, we can identify distinct and clinically relevant histomolecular phenotypes in adenocarcinomas of the ampulla of Vater, which could have considerable impact on existing therapeutic approaches." @default.
• W4387252803 created "2023-10-03" @default.
• W4387252803 creator A5023344582 @default.
• W4387252803 creator A5023527433 @default.
• W4387252803 creator A5029272421 @default.
• W4387252803 creator A5037504599 @default.
• W4387252803 creator A5052369288 @default.
• W4387252803 creator A5064895996 @default.
• W4387252803 creator A5090724229 @default.
• W4387252803 date "2023-10-02" @default.
• W4387252803 modified "2023-10-16" @default.
• W4387252803 title "Histologic subtype-based evaluation of recurrence and survival outcomes in patients with adenocarcinoma of the ampulla of Vater" @default.
• W4387252803 cites W1501109929 @default.
• W4387252803 cites W1995797355 @default.
• W4387252803 cites W2075325375 @default.
• W4387252803 cites W2079979149 @default.
• W4387252803 cites W2131223689 @default.
• W4387252803 cites W2132393087 @default.
• W4387252803 cites W2170374942 @default.
• W4387252803 cites W2204134524 @default.
• W4387252803 cites W2329954599 @default.
• W4387252803 cites W2508774475 @default.
• W4387252803 cites W2510940410 @default.
• W4387252803 cites W2995172494 @default.
• W4387252803 cites W3001536966 @default.
• W4387252803 cites W3014083264 @default.
• W4387252803 cites W3014908839 @default.
• W4387252803 cites W3018209197 @default.
• W4387252803 cites W3132103429 @default.
• W4387252803 cites W4206747136 @default.
• W4387252803 cites W4225679537 @default.
• W4387252803 cites W4303859375 @default.
• W4387252803 cites W4317488871 @default.
• W4387252803 doi "https://doi.org/10.1038/s41598-023-42386-6" @default.
• W4387252803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37783755" @default.
• W4387252803 hasPublicationYear "2023" @default.
• W4387252803 type Work @default.
• W4387252803 citedByCount "0" @default.
• W4387252803 crossrefType "journal-article" @default.
• W4387252803 hasAuthorship W4387252803A5023344582 @default.
• W4387252803 hasAuthorship W4387252803A5023527433 @default.
• W4387252803 hasAuthorship W4387252803A5029272421 @default.
• W4387252803 hasAuthorship W4387252803A5037504599 @default.
• W4387252803 hasAuthorship W4387252803A5052369288 @default.
• W4387252803 hasAuthorship W4387252803A5064895996 @default.
• W4387252803 hasAuthorship W4387252803A5090724229 @default.
• W4387252803 hasBestOaLocation W43872528031 @default.
• W4387252803 hasConcept C104317684 @default.
• W4387252803 hasConcept C121587040 @default.
• W4387252803 hasConcept C121608353 @default.
• W4387252803 hasConcept C126322002 @default.
• W4387252803 hasConcept C131364181 @default.
• W4387252803 hasConcept C143998085 @default.
• W4387252803 hasConcept C150194340 @default.
• W4387252803 hasConcept C151730666 @default.
• W4387252803 hasConcept C2777522975 @default.
• W4387252803 hasConcept C2777546739 @default.
• W4387252803 hasConcept C2779343474 @default.
• W4387252803 hasConcept C2780840399 @default.
• W4387252803 hasConcept C2781182431 @default.
• W4387252803 hasConcept C55493867 @default.
• W4387252803 hasConcept C71924100 @default.
• W4387252803 hasConcept C72563966 @default.
• W4387252803 hasConcept C86803240 @default.
• W4387252803 hasConcept C90924648 @default.
• W4387252803 hasConceptScore W4387252803C104317684 @default.
• W4387252803 hasConceptScore W4387252803C121587040 @default.
• W4387252803 hasConceptScore W4387252803C121608353 @default.
• W4387252803 hasConceptScore W4387252803C126322002 @default.
• W4387252803 hasConceptScore W4387252803C131364181 @default.
• W4387252803 hasConceptScore W4387252803C143998085 @default.
• W4387252803 hasConceptScore W4387252803C150194340 @default.
• W4387252803 hasConceptScore W4387252803C151730666 @default.
• W4387252803 hasConceptScore W4387252803C2777522975 @default.
• W4387252803 hasConceptScore W4387252803C2777546739 @default.
• W4387252803 hasConceptScore W4387252803C2779343474 @default.
• W4387252803 hasConceptScore W4387252803C2780840399 @default.
• W4387252803 hasConceptScore W4387252803C2781182431 @default.
• W4387252803 hasConceptScore W4387252803C55493867 @default.
• W4387252803 hasConceptScore W4387252803C71924100 @default.
• W4387252803 hasConceptScore W4387252803C72563966 @default.
• W4387252803 hasConceptScore W4387252803C86803240 @default.
• W4387252803 hasConceptScore W4387252803C90924648 @default.
• W4387252803 hasIssue "1" @default.
• W4387252803 hasLocation W43872528031 @default.
• W4387252803 hasLocation W43872528032 @default.
• W4387252803 hasOpenAccess W4387252803 @default.
• W4387252803 hasPrimaryLocation W43872528031 @default.
• W4387252803 hasRelatedWork W159267784 @default.
• W4387252803 hasRelatedWork W2022137006 @default.
• W4387252803 hasRelatedWork W2054886722 @default.
• W4387252803 hasRelatedWork W2169573902 @default.
• W4387252803 hasRelatedWork W2280635312 @default.
• W4387252803 hasRelatedWork W2409950522 @default.
• W4387252803 hasRelatedWork W2441138547 @default.
• W4387252803 hasRelatedWork W2484831236 @default.
• W4387252803 hasRelatedWork W2902607886 @default.
• W4387252803 hasRelatedWork W2997684353 @default.
• W4387252803 hasVolume "13" @default.
• W4387252803 isParatext "false" @default.

• next