Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387253066> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4387253066 abstract "Adult survivors of cancer are at increased risk of cardiovascular disease (CVD). Indeed, while CVD emerges as the second leading cause of death in recovering cancer patients, cross-disease communication remains poorly understood. We previously demonstrated that myocardial infarction (MI) accelerates breast cancer tumor growth and cancer-specific mortality in mice and humans. However, whether MI alters tumor growth of other cancer types and impacts metastasis is not known. To assess these gaps, we examined the effect of acute MI, induced by ligation of the left anterior descending (LAD) coronary artery, in syngeneic C57BL6 mouse models of primary and metastatic melanoma. Compared to sham surgery, LAD ligation resulted in a two-fold increase in tumor growth in both the B16 and YUMM melanoma models. Notably, tumor burden significantly correlated with the size of the infarct, suggesting a direct relationship between injury signal activation and disease progression. Analysis of the intratumoral immune cell landscape by flow cytometry revealed an enrichment of immunosuppressive CD4 + FoxP3 + T regulatory (Treg) cells after MI. Furthermore, histological analysis and magnetic resonance imaging revealed an increase in the number and size of metastatic foci in the liver after MI compared to sham. Our data suggest that MI dampens antitumor immunity and reorganizes the tumor microenvironment to exacerbate tumor progression in multiple cancer types. Collectively, these findings of deleterious cross-disease communication underscore the importance of implementing strategies that mitigate CVD risk in cancer patients." @default.
- W4387253066 created "2023-10-03" @default.
- W4387253066 creator A5003105711 @default.
- W4387253066 creator A5020269484 @default.
- W4387253066 creator A5020849436 @default.
- W4387253066 creator A5035258831 @default.
- W4387253066 creator A5049085301 @default.
- W4387253066 creator A5049605039 @default.
- W4387253066 creator A5052815476 @default.
- W4387253066 creator A5092985503 @default.
- W4387253066 date "2023-05-01" @default.
- W4387253066 modified "2023-10-03" @default.
- W4387253066 title "Abstract 354: Myocardial Infarction Accelerates Melanoma Tumor Growth And Metastasis" @default.
- W4387253066 doi "https://doi.org/10.1161/atvb.43.suppl_1.354" @default.
- W4387253066 hasPublicationYear "2023" @default.
- W4387253066 type Work @default.
- W4387253066 citedByCount "0" @default.
- W4387253066 crossrefType "journal-article" @default.
- W4387253066 hasAuthorship W4387253066A5003105711 @default.
- W4387253066 hasAuthorship W4387253066A5020269484 @default.
- W4387253066 hasAuthorship W4387253066A5020849436 @default.
- W4387253066 hasAuthorship W4387253066A5035258831 @default.
- W4387253066 hasAuthorship W4387253066A5049085301 @default.
- W4387253066 hasAuthorship W4387253066A5049605039 @default.
- W4387253066 hasAuthorship W4387253066A5052815476 @default.
- W4387253066 hasAuthorship W4387253066A5092985503 @default.
- W4387253066 hasConcept C121608353 @default.
- W4387253066 hasConcept C126322002 @default.
- W4387253066 hasConcept C142724271 @default.
- W4387253066 hasConcept C143998085 @default.
- W4387253066 hasConcept C203014093 @default.
- W4387253066 hasConcept C2776107976 @default.
- W4387253066 hasConcept C2777658100 @default.
- W4387253066 hasConcept C2779013556 @default.
- W4387253066 hasConcept C2779256057 @default.
- W4387253066 hasConcept C2779727006 @default.
- W4387253066 hasConcept C500558357 @default.
- W4387253066 hasConcept C502942594 @default.
- W4387253066 hasConcept C530470458 @default.
- W4387253066 hasConcept C71924100 @default.
- W4387253066 hasConcept C8891405 @default.
- W4387253066 hasConceptScore W4387253066C121608353 @default.
- W4387253066 hasConceptScore W4387253066C126322002 @default.
- W4387253066 hasConceptScore W4387253066C142724271 @default.
- W4387253066 hasConceptScore W4387253066C143998085 @default.
- W4387253066 hasConceptScore W4387253066C203014093 @default.
- W4387253066 hasConceptScore W4387253066C2776107976 @default.
- W4387253066 hasConceptScore W4387253066C2777658100 @default.
- W4387253066 hasConceptScore W4387253066C2779013556 @default.
- W4387253066 hasConceptScore W4387253066C2779256057 @default.
- W4387253066 hasConceptScore W4387253066C2779727006 @default.
- W4387253066 hasConceptScore W4387253066C500558357 @default.
- W4387253066 hasConceptScore W4387253066C502942594 @default.
- W4387253066 hasConceptScore W4387253066C530470458 @default.
- W4387253066 hasConceptScore W4387253066C71924100 @default.
- W4387253066 hasConceptScore W4387253066C8891405 @default.
- W4387253066 hasIssue "Suppl_1" @default.
- W4387253066 hasLocation W43872530661 @default.
- W4387253066 hasOpenAccess W4387253066 @default.
- W4387253066 hasPrimaryLocation W43872530661 @default.
- W4387253066 hasRelatedWork W2052678194 @default.
- W4387253066 hasRelatedWork W2224319365 @default.
- W4387253066 hasRelatedWork W2331606468 @default.
- W4387253066 hasRelatedWork W2413189820 @default.
- W4387253066 hasRelatedWork W2623003466 @default.
- W4387253066 hasRelatedWork W2747570594 @default.
- W4387253066 hasRelatedWork W2904294837 @default.
- W4387253066 hasRelatedWork W3085168500 @default.
- W4387253066 hasRelatedWork W3105410425 @default.
- W4387253066 hasRelatedWork W3208122506 @default.
- W4387253066 hasVolume "43" @default.
- W4387253066 isParatext "false" @default.
- W4387253066 isRetracted "false" @default.
- W4387253066 workType "article" @default.