FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387253100> ?p ?o ?g. }

• W4387253100 abstract "Aerobic exercise can prevent aortopathy in mouse models. The objective of this study was to better understand the mechanisms underlying this finding. Mice treated with β-aminopropionitrile (BAPN), an irreversible inhibitor of lysyl oxidase (LOX) which induces thoracic aortic aneurysm and dissection (TAAD), underwent either a forced moderate treadmill regimen or maintained conventional cage activity without forced exercise. RNA sequencing was utilized to determine the transcriptomic profile of the ascending and thoracic aorta (n=7 per group). BAPN induced overexpression of 357 genes and decreased expression of 77 genes compared with controls. Causal analysis in Ingenuity Pathway Analysis® software using a fold change |2| and FDR < 0.05 revealed that BAPN activates phagosome formation, leukocyte extravasation, phagocytosis, hepatic fibrosis signaling, neuroinflammation signaling, production of nitric oxide and reactive oxygen species in macrophages, leukocyte migration and inflammatory response, among other pathways, in the aorta (z-score > 2, p-value < 0.05). Pathways of the overexpressed upstream regulators TYROBP, IL6, SPI1, IL1B, CCR2, and TGFβ1, among others, were predicted to be activated (z-score > 2, BH p-value of overlap < 0.05). A comparison analysis between the two groups sorted by trend and score demonstrates that moderate aerobic exercise reverses the predicted activation of these pathways. Next, we investigated whether activated TGFβ1 signaling, predicted to be normalized with exercise compared with unexercised mice, is required for the aortopathy caused by LOX inhibition. We administered SB431542, a selective small peptide inhibitor of the TGF-β1 receptor (TGF-β1R), to a separate cohort of BAPN-treated mice. Histologic analysis demonstrated that the addition of the TGF-β1R inhibitor reverses many of the histologic changes characteristic of BAPN-induced aortopathy, including reversal of wall thickening (p < 0.001), elastin degradation (p < 0.01), and cystic medial degeneration (p = 0.04) in the thoracic aorta. While further investigation is necessary, our study suggests that the prevention of TAAD and its complications by moderate aerobic exercise may in part be due to deactivation of the dysregulated TGF-β1 pathway." @default.
• W4387253100 created "2023-10-03" @default.
• W4387253100 creator A5040412256 @default.
• W4387253100 creator A5049969799 @default.
• W4387253100 creator A5060808863 @default.
• W4387253100 creator A5066523414 @default.
• W4387253100 creator A5076236165 @default.
• W4387253100 creator A5090416742 @default.
• W4387253100 date "2023-05-01" @default.
• W4387253100 modified "2023-10-03" @default.
• W4387253100 title "Abstract 268: Exercise Modulates Inflammatory, Cytokine, And Growth Factor Pathway Dysregulation In A Mouse Model Of Aortic Dissection And Aneurysm" @default.
• W4387253100 doi "https://doi.org/10.1161/atvb.43.suppl_1.268" @default.
• W4387253100 hasPublicationYear "2023" @default.
• W4387253100 type Work @default.
• W4387253100 citedByCount "0" @default.
• W4387253100 crossrefType "journal-article" @default.
• W4387253100 hasAuthorship W4387253100A5040412256 @default.
• W4387253100 hasAuthorship W4387253100A5049969799 @default.
• W4387253100 hasAuthorship W4387253100A5060808863 @default.
• W4387253100 hasAuthorship W4387253100A5066523414 @default.
• W4387253100 hasAuthorship W4387253100A5076236165 @default.
• W4387253100 hasAuthorship W4387253100A5090416742 @default.
• W4387253100 hasConcept C126322002 @default.
• W4387253100 hasConcept C181199279 @default.
• W4387253100 hasConcept C203014093 @default.
• W4387253100 hasConcept C2777323849 @default.
• W4387253100 hasConcept C2778249958 @default.
• W4387253100 hasConcept C2779540182 @default.
• W4387253100 hasConcept C2779980429 @default.
• W4387253100 hasConcept C2780847584 @default.
• W4387253100 hasConcept C2781044401 @default.
• W4387253100 hasConcept C55493867 @default.
• W4387253100 hasConcept C71924100 @default.
• W4387253100 hasConcept C86803240 @default.
• W4387253100 hasConceptScore W4387253100C126322002 @default.
• W4387253100 hasConceptScore W4387253100C181199279 @default.
• W4387253100 hasConceptScore W4387253100C203014093 @default.
• W4387253100 hasConceptScore W4387253100C2777323849 @default.
• W4387253100 hasConceptScore W4387253100C2778249958 @default.
• W4387253100 hasConceptScore W4387253100C2779540182 @default.
• W4387253100 hasConceptScore W4387253100C2779980429 @default.
• W4387253100 hasConceptScore W4387253100C2780847584 @default.
• W4387253100 hasConceptScore W4387253100C2781044401 @default.
• W4387253100 hasConceptScore W4387253100C55493867 @default.
• W4387253100 hasConceptScore W4387253100C71924100 @default.
• W4387253100 hasConceptScore W4387253100C86803240 @default.
• W4387253100 hasIssue "Suppl_1" @default.
• W4387253100 hasLocation W43872531001 @default.
• W4387253100 hasOpenAccess W4387253100 @default.
• W4387253100 hasPrimaryLocation W43872531001 @default.
• W4387253100 hasRelatedWork W1981943396 @default.
• W4387253100 hasRelatedWork W2087848704 @default.
• W4387253100 hasRelatedWork W2112817375 @default.
• W4387253100 hasRelatedWork W2143391260 @default.
• W4387253100 hasRelatedWork W2165968747 @default.
• W4387253100 hasRelatedWork W2396360127 @default.
• W4387253100 hasRelatedWork W2784345858 @default.
• W4387253100 hasRelatedWork W3095706342 @default.
• W4387253100 hasRelatedWork W3167234455 @default.
• W4387253100 hasRelatedWork W4221064769 @default.
• W4387253100 hasVolume "43" @default.
• W4387253100 isParatext "false" @default.
• W4387253100 isRetracted "false" @default.
• W4387253100 workType "article" @default.