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• W4387253896 abstract "SESSION TITLE: Novel Biomarkers of Asthma and COPD Severity SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/09/2023 12:00 pm - 12:45 pm PURPOSE: Our study aimed to investigate the clinical impact of exercise-induced desaturation (EID) in chronic obstructive pulmonary disease (COPD) patients. Furthermore, we analyzed the factors associated with the presence of EID. METHODS: This study was based on Korea COPD Subgroup Study (KOCOSS) database, which is a multicenter cohort study that prospectively recruited COPD patients from 54 medical centers in South Korea since April 2012. We categorized patients into EID (+) and (-) using 6-min walk test (6MWT); EID was defined as a decrease of at least 4% in post-exercise oxygen saturation (SpO2) or a SpO2 level of less than 90%. We analyzed differences of baseline characteristics and 1-yr exacerbation rates in COPD patients according to EID. We also analyzed factors associated with EID positivity. RESULTS: Among 1,491 patients enrolled in this study, 335 (22.5%) patients were categorized as EID (+). EID (+) patients were more likely to be older, past smokers and lower in BMI compared to EID (-) patients. Moreover, EID (+) patients had higher mMRC (1.2±0.8 VS 1.6±0.9, p<0.01), CAT (13.9±7.9, p<0.01) and SGRQ score (30.0±18.2 ± 38.1±19.8, p<0.01), with lower FEV1 (1,8±0.6, p<0.01), FVC (3.4±0.8 vs 3.2±0.8, p<0.01), FEV1/FVC (52.0±12.2 vs 44.5±13.1, p<0.01), and DLco (67.5±19.7 vs 53.1±18.7, p<0.01). EID (+) patients showed more frequent emphysema in the CT images (43.2% vs 56.1%, p<0.01). In 1-year follow-up data, moderate-to-severe exacerbation was more frequent in EID (+) patients compared to EID (-) patients (IRR 1.43 95%CI 1.12-1.85), but there were no significant differences in the frequency of severe exacerbations between two groups (IRR 1.21 95% CI 0.72-2.00). Presence of EIB was associated with lower FEV1 and DLco, higher FVC, and emphysema. CONCLUSIONS: EID was associated with poor symptoms, health-related quality of life and lung function. Also, those with EID was associated with frequent moderate-to-severe exacerbation compared to EID (-) patients. Presence of EID was associated with poor lung function and emphysema. CLINICAL IMPLICATIONS: Clinicians should keep in mind that EID is associated with poor clinical outcomes in COPD patients. DISCLOSURES: No relevant relationships by Joon Young Choi No relevant relationships by Ki-Suck Jung No relevant relationships by Yoo Jung LEE No relevant relationships by Chin Kook Rhee No relevant relationships by KWANG HA YOO" @default.
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• W4387253896 date "2023-10-01" @default.
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• W4387253896 title "EXERCISE-INDUCED DESATURATION IS ASSOCIATED WITH FREQUENT EXACERBATIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE" @default.
• W4387253896 doi "https://doi.org/10.1016/j.chest.2023.07.3177" @default.
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