Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387259675> ?p ?o ?g. }
- W4387259675 abstract "Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment. The versatility and sophisticated mechanisms of CAFs in facilitating cancer progression have been elucidated extensively, including promoting cancer angiogenesis and metastasis, inducing drug resistance, reshaping the extracellular matrix, and developing an immunosuppressive microenvironment. Owing to their robust tumor-promoting function, CAFs are considered a promising target for oncotherapy. However, CAFs are a highly heterogeneous group of cells. Some subpopulations exert an inhibitory role in tumor growth, which implies that CAF-targeting approaches must be more precise and individualized. This review comprehensively summarize the origin, phenotypical, and functional heterogeneity of CAFs. More importantly, we underscore advances in strategies and clinical trials to target CAF in various cancers, and we also summarize progressions of CAF in cancer immunotherapy." @default.
- W4387259675 created "2023-10-03" @default.
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- W4387259675 date "2023-10-02" @default.
- W4387259675 modified "2023-10-14" @default.
- W4387259675 title "Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials" @default.
- W4387259675 cites W1487455823 @default.
- W4387259675 cites W1492166511 @default.
- W4387259675 cites W1824834086 @default.
- W4387259675 cites W1868626511 @default.
- W4387259675 cites W1947290102 @default.
- W4387259675 cites W1952391983 @default.
- W4387259675 cites W1971298987 @default.
- W4387259675 cites W1973147485 @default.
- W4387259675 cites W1978148663 @default.
- W4387259675 cites W1983575915 @default.
- W4387259675 cites W1984182254 @default.
- W4387259675 cites W1985450903 @default.
- W4387259675 cites W1987246433 @default.
- W4387259675 cites W1996912024 @default.
- W4387259675 cites W1998266575 @default.
- W4387259675 cites W2002689409 @default.
- W4387259675 cites W2009165570 @default.
- W4387259675 cites W2015616022 @default.
- W4387259675 cites W2018404994 @default.
- W4387259675 cites W2020914260 @default.
- W4387259675 cites W2024673806 @default.
- W4387259675 cites W2026067651 @default.
- W4387259675 cites W2026727204 @default.
- W4387259675 cites W2036144830 @default.
- W4387259675 cites W2045136333 @default.
- W4387259675 cites W2047833833 @default.
- W4387259675 cites W2048253455 @default.
- W4387259675 cites W2054282870 @default.
- W4387259675 cites W2055091294 @default.
- W4387259675 cites W2057854840 @default.
- W4387259675 cites W2061135361 @default.
- W4387259675 cites W2065215232 @default.
- W4387259675 cites W2069138395 @default.
- W4387259675 cites W2076891934 @default.
- W4387259675 cites W2085121865 @default.
- W4387259675 cites W2086585598 @default.
- W4387259675 cites W2086834665 @default.
- W4387259675 cites W2088110734 @default.
- W4387259675 cites W2092893236 @default.
- W4387259675 cites W2101037339 @default.
- W4387259675 cites W2102790879 @default.
- W4387259675 cites W2102829128 @default.
- W4387259675 cites W2103328690 @default.
- W4387259675 cites W2107474091 @default.
- W4387259675 cites W2110836783 @default.
- W4387259675 cites W2112362882 @default.
- W4387259675 cites W2113472355 @default.
- W4387259675 cites W2117692326 @default.
- W4387259675 cites W2118323175 @default.
- W4387259675 cites W2127258026 @default.
- W4387259675 cites W2130464657 @default.
- W4387259675 cites W2131635221 @default.
- W4387259675 cites W2132884665 @default.
- W4387259675 cites W2137217704 @default.
- W4387259675 cites W2137816700 @default.
- W4387259675 cites W2139256273 @default.
- W4387259675 cites W2139325323 @default.
- W4387259675 cites W2145007757 @default.
- W4387259675 cites W2153543784 @default.
- W4387259675 cites W2153565541 @default.
- W4387259675 cites W2153895029 @default.
- W4387259675 cites W2155533522 @default.
- W4387259675 cites W2158770220 @default.
- W4387259675 cites W2161214210 @default.
- W4387259675 cites W2175412058 @default.
- W4387259675 cites W2259627090 @default.
- W4387259675 cites W2261120022 @default.
- W4387259675 cites W2284993453 @default.
- W4387259675 cites W2317505970 @default.
- W4387259675 cites W2333625845 @default.
- W4387259675 cites W2336612200 @default.
- W4387259675 cites W2400022769 @default.
- W4387259675 cites W2413827320 @default.
- W4387259675 cites W2417242092 @default.
- W4387259675 cites W2442704894 @default.
- W4387259675 cites W2469526389 @default.
- W4387259675 cites W2508340131 @default.
- W4387259675 cites W2510540705 @default.
- W4387259675 cites W2512899508 @default.
- W4387259675 cites W2513249090 @default.
- W4387259675 cites W2515672204 @default.
- W4387259675 cites W2520149271 @default.
- W4387259675 cites W2538881992 @default.