Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387259826> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4387259826 abstract "<div>Abstract<p>Clear cell renal cell carcinoma (ccRCC) is the most common subtype of lethal kidney cancer. Reprogramming of fatty acid and glucose metabolism resulting in the accumulation of lipids and glycogen in the cytoplasm is a hallmark of ccRCC. Here, we identified a micropeptide ACLY-BP encoded by the GATA3-suppressed <i>LINC00887</i>, which regulated lipid metabolism and promoted cell proliferation and tumor growth in ccRCC. Mechanistically, the ACLY-BP stabilizes the ATP citrate lyase (ACLY) by maintaining ACLY acetylation and preventing ACLY from ubiquitylation and degradation, thereby leading to lipid deposition in ccRCC and promoting cell proliferation. Our results may offer a new clue for the therapeutic approaches and the diagnostic assessment for ccRCC.</p>Implications:<p>This study identifies ACLY-BP encoded by <i>LINC00887</i> as a lipid-related micropeptide that stabilizes ACLY to generate acetyl-CoA, driving lipid deposition and promoting cell proliferation in ccRCC.</p></div>" @default.
- W4387259826 created "2023-10-03" @default.
- W4387259826 creator A5007870500 @default.
- W4387259826 creator A5008231635 @default.
- W4387259826 creator A5015158690 @default.
- W4387259826 creator A5022083226 @default.
- W4387259826 creator A5025541226 @default.
- W4387259826 creator A5036905517 @default.
- W4387259826 creator A5049763932 @default.
- W4387259826 creator A5054280511 @default.
- W4387259826 creator A5057488182 @default.
- W4387259826 creator A5061237869 @default.
- W4387259826 creator A5066278341 @default.
- W4387259826 creator A5067734881 @default.
- W4387259826 creator A5068612123 @default.
- W4387259826 creator A5073559277 @default.
- W4387259826 creator A5080970346 @default.
- W4387259826 creator A5092501420 @default.
- W4387259826 date "2023-10-02" @default.
- W4387259826 modified "2023-10-17" @default.
- W4387259826 title "Data from LncRNA-Encoded Micropeptide ACLY-BP Drives Lipid Deposition and Cell Proliferation in Clear Cell Renal Cell Carcinoma via Maintenance of ACLY Acetylation" @default.
- W4387259826 doi "https://doi.org/10.1158/1541-7786.c.6749985.v2" @default.
- W4387259826 hasPublicationYear "2023" @default.
- W4387259826 type Work @default.
- W4387259826 citedByCount "0" @default.
- W4387259826 crossrefType "posted-content" @default.
- W4387259826 hasAuthorship W4387259826A5007870500 @default.
- W4387259826 hasAuthorship W4387259826A5008231635 @default.
- W4387259826 hasAuthorship W4387259826A5015158690 @default.
- W4387259826 hasAuthorship W4387259826A5022083226 @default.
- W4387259826 hasAuthorship W4387259826A5025541226 @default.
- W4387259826 hasAuthorship W4387259826A5036905517 @default.
- W4387259826 hasAuthorship W4387259826A5049763932 @default.
- W4387259826 hasAuthorship W4387259826A5054280511 @default.
- W4387259826 hasAuthorship W4387259826A5057488182 @default.
- W4387259826 hasAuthorship W4387259826A5061237869 @default.
- W4387259826 hasAuthorship W4387259826A5066278341 @default.
- W4387259826 hasAuthorship W4387259826A5067734881 @default.
- W4387259826 hasAuthorship W4387259826A5068612123 @default.
- W4387259826 hasAuthorship W4387259826A5073559277 @default.
- W4387259826 hasAuthorship W4387259826A5080970346 @default.
- W4387259826 hasAuthorship W4387259826A5092501420 @default.
- W4387259826 hasConcept C111133373 @default.
- W4387259826 hasConcept C126322002 @default.
- W4387259826 hasConcept C1491633281 @default.
- W4387259826 hasConcept C181199279 @default.
- W4387259826 hasConcept C185592680 @default.
- W4387259826 hasConcept C204999636 @default.
- W4387259826 hasConcept C2777472916 @default.
- W4387259826 hasConcept C2781278892 @default.
- W4387259826 hasConcept C4733338 @default.
- W4387259826 hasConcept C502942594 @default.
- W4387259826 hasConcept C55493867 @default.
- W4387259826 hasConcept C62112901 @default.
- W4387259826 hasConcept C71924100 @default.
- W4387259826 hasConcept C86803240 @default.
- W4387259826 hasConcept C95444343 @default.
- W4387259826 hasConceptScore W4387259826C111133373 @default.
- W4387259826 hasConceptScore W4387259826C126322002 @default.
- W4387259826 hasConceptScore W4387259826C1491633281 @default.
- W4387259826 hasConceptScore W4387259826C181199279 @default.
- W4387259826 hasConceptScore W4387259826C185592680 @default.
- W4387259826 hasConceptScore W4387259826C204999636 @default.
- W4387259826 hasConceptScore W4387259826C2777472916 @default.
- W4387259826 hasConceptScore W4387259826C2781278892 @default.
- W4387259826 hasConceptScore W4387259826C4733338 @default.
- W4387259826 hasConceptScore W4387259826C502942594 @default.
- W4387259826 hasConceptScore W4387259826C55493867 @default.
- W4387259826 hasConceptScore W4387259826C62112901 @default.
- W4387259826 hasConceptScore W4387259826C71924100 @default.
- W4387259826 hasConceptScore W4387259826C86803240 @default.
- W4387259826 hasConceptScore W4387259826C95444343 @default.
- W4387259826 hasLocation W43872598261 @default.
- W4387259826 hasOpenAccess W4387259826 @default.
- W4387259826 hasPrimaryLocation W43872598261 @default.
- W4387259826 hasRelatedWork W1973332845 @default.
- W4387259826 hasRelatedWork W2083693850 @default.
- W4387259826 hasRelatedWork W2466803535 @default.
- W4387259826 hasRelatedWork W2470436178 @default.
- W4387259826 hasRelatedWork W2801726940 @default.
- W4387259826 hasRelatedWork W2901347534 @default.
- W4387259826 hasRelatedWork W2966940571 @default.
- W4387259826 hasRelatedWork W3000191286 @default.
- W4387259826 hasRelatedWork W3026260494 @default.
- W4387259826 hasRelatedWork W3195373684 @default.
- W4387259826 isParatext "false" @default.
- W4387259826 isRetracted "false" @default.
- W4387259826 workType "article" @default.