FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387259849> ?p ?o ?g. }

• W4387259849 endingPage "6877" @default.
• W4387259849 startingPage "6877" @default.
• W4387259849 abstract "This study explores the edaravone solubility space encompassing both neat and binary dissolution media. Efforts were made to reveal the inherent concentration limits of common pure and mixed solvents. For this purpose, the published solubility data of the title drug were scrupulously inspected and cured, which made the dataset consistent and coherent. However, the lack of some important types of solvents in the collection called for an extension of the available pool of edaravone solubility data. Hence, new measurements were performed to collect edaravone solubility values in polar non-protic and diprotic media. Such an extended set of data was used in the machine learning process for tuning the parameters of regressor models and formulating the ensemble for predicting new data. In both phases, namely the model training and ensemble formulation, close attention was paid not only to minimizing the deviation of computed values from the experimental ones but also to ensuring high predictive power and accurate solubility computations for new systems. Furthermore, the environmental friendliness characteristics determined based on the common green solvent selection criteria, were included in the analysis. Our applied protocol led to the conclusion that the solubility space defined by ordinary solvents is limited, and it is unlikely to find solvents that are better suited for edaravone dissolution than those described in this manuscript. The theoretical framework presented in this study provides a precise guideline for conducting experiments, as well as saving time and resources in the pursuit of new findings." @default.
• W4387259849 created "2023-10-03" @default.
• W4387259849 creator A5011887004 @default.
• W4387259849 creator A5069739902 @default.
• W4387259849 creator A5076724836 @default.
• W4387259849 creator A5083764373 @default.
• W4387259849 creator A5084777699 @default.
• W4387259849 date "2023-09-29" @default.
• W4387259849 modified "2023-10-18" @default.
• W4387259849 title "Exploring the Solubility Limits of Edaravone in Neat Solvents and Binary Mixtures: Experimental and Machine Learning Study" @default.
• W4387259849 cites W1121049720 @default.
• W4387259849 cites W1498305210 @default.
• W4387259849 cites W1551729708 @default.
• W4387259849 cites W179229969 @default.
• W4387259849 cites W1840182658 @default.
• W4387259849 cites W1974210920 @default.
• W4387259849 cites W1975299106 @default.
• W4387259849 cites W1980017694 @default.
• W4387259849 cites W1998086089 @default.
• W4387259849 cites W1998451783 @default.
• W4387259849 cites W2000493396 @default.
• W4387259849 cites W2006079279 @default.
• W4387259849 cites W2019647119 @default.
• W4387259849 cites W2028022118 @default.
• W4387259849 cites W2044392760 @default.
• W4387259849 cites W2055563809 @default.
• W4387259849 cites W2055655387 @default.
• W4387259849 cites W2061928877 @default.
• W4387259849 cites W2069619511 @default.
• W4387259849 cites W2074270552 @default.
• W4387259849 cites W2078120815 @default.
• W4387259849 cites W2079086794 @default.
• W4387259849 cites W2087184000 @default.
• W4387259849 cites W2114514252 @default.
• W4387259849 cites W2151823004 @default.
• W4387259849 cites W2156829937 @default.
• W4387259849 cites W2162681864 @default.
• W4387259849 cites W2325893528 @default.
• W4387259849 cites W2524377574 @default.
• W4387259849 cites W2592474667 @default.
• W4387259849 cites W2592620213 @default.
• W4387259849 cites W2602256685 @default.
• W4387259849 cites W2608979236 @default.
• W4387259849 cites W2783703994 @default.
• W4387259849 cites W2870204682 @default.
• W4387259849 cites W2896778526 @default.
• W4387259849 cites W2913532116 @default.
• W4387259849 cites W2949676527 @default.
• W4387259849 cites W2952930842 @default.
• W4387259849 cites W2964481467 @default.
• W4387259849 cites W3010137304 @default.
• W4387259849 cites W3024985618 @default.
• W4387259849 cites W3129244780 @default.
• W4387259849 cites W3133942930 @default.
• W4387259849 cites W3134672947 @default.
• W4387259849 cites W3156297990 @default.
• W4387259849 cites W3157838782 @default.
• W4387259849 cites W3177844093 @default.
• W4387259849 cites W3178803434 @default.
• W4387259849 cites W3179844238 @default.
• W4387259849 cites W3181953882 @default.
• W4387259849 cites W3205024696 @default.
• W4387259849 cites W3208907164 @default.
• W4387259849 cites W3211742238 @default.
• W4387259849 cites W3214882609 @default.
• W4387259849 cites W4210430917 @default.
• W4387259849 cites W4210449401 @default.
• W4387259849 cites W4281757722 @default.
• W4387259849 cites W4292222777 @default.
• W4387259849 cites W4293029499 @default.
• W4387259849 cites W4298625468 @default.
• W4387259849 cites W4312196419 @default.
• W4387259849 cites W4313894683 @default.
• W4387259849 cites W4321505570 @default.
• W4387259849 cites W4361248200 @default.
• W4387259849 cites W4382464253 @default.
• W4387259849 cites W4385379264 @default.
• W4387259849 doi "https://doi.org/10.3390/molecules28196877" @default.
• W4387259849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37836720" @default.
• W4387259849 hasPublicationYear "2023" @default.
• W4387259849 type Work @default.
• W4387259849 citedByCount "0" @default.
• W4387259849 crossrefType "journal-article" @default.
• W4387259849 hasAuthorship W4387259849A5011887004 @default.
• W4387259849 hasAuthorship W4387259849A5069739902 @default.
• W4387259849 hasAuthorship W4387259849A5076724836 @default.
• W4387259849 hasAuthorship W4387259849A5083764373 @default.
• W4387259849 hasAuthorship W4387259849A5084777699 @default.
• W4387259849 hasBestOaLocation W43872598491 @default.
• W4387259849 hasConcept C111919701 @default.
• W4387259849 hasConcept C121332964 @default.
• W4387259849 hasConcept C127413603 @default.
• W4387259849 hasConcept C142724271 @default.
• W4387259849 hasConcept C155574463 @default.
• W4387259849 hasConcept C178790620 @default.
• W4387259849 hasConcept C185592680 @default.
• W4387259849 hasConcept C204787440 @default.
• W4387259849 hasConcept C21880701 @default.

• next