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• W4387260037 abstract "<p>Birinapant and fulvestrant enhance antigen presentation, T-cell migration, and T-cell–mediated cytotoxicity. <b>A,</b> mRNA expression levels of IFNγ and antigen presentation–related genes in MCF7 cells that were treated with vehicle control (DMSO), fulvestrant (10 nmol/L), birinapant (100 nmol/L), and the combination of fulvestrant and birinapant for 3 days and stimulated with IFNγ for the last 24 hours. <b>B–E,</b> Median fluorescence intensity (MFI) quantification of MHC-I and PD-L1 levels assessed by flow cytometry in MCF7 cells grown in HD or in the presence of E2 (<b>B</b> and <b>C</b>) or treated with fulvestrant (10 nmol/L; <b>D</b> and <b>E</b>), and treated with the addition of doses of birinapant for 3 days. Cells were stimulated with IFNγ (10 ng/mL) for the last 24 hours. MFI levels are relative to no-IFNγ conditions (*, <i>P</i> < 0.05; ***, <i>P</i>< 0.001; n.s., not significant). Error bars, mean ± SD of at least two replicates. <b>F,</b> Whole-cell lysates immunoblots of ER, NF-KB subunits, and IFNγ target genes in MCF7 cells grown treated with vehicle control (DMSO), fulvestrant (10 nmol/L), birinapant (100 nmol/L), and the combination with and without IFNγ (10 ng/mL) stimulation for 24 hours. <b>G,</b> Representative immunofluorescence images from T-cell migration assay after treatment with vehicle control (DMSO), fulvestrant (10 nmol/L), birinapant (100 nmol/L), and the combination MCF7 cells were pretreated and seeded in the AIM 3D cell culture chips. Primary CD8⁺ T cells stained with CellTrace Red Stain were seeded on the lateral channels. <b>H,</b> Quantification of migration to the matrix was measured after 5 days (*, <i>P</i> < 0.05. Error bars are mean ± SD of at least 5 replicates. Two-way ANOVA). <b>I,</b> Representative figures of immunofluorescent stains of cocultured MCF7_NYESO1 and T cells transduced with NYESO1-specific TCR. Immunofluorescent stains include MHC-I (red), granzyme B (green), actin (yellow), DAPI for nuclear staining (blue), and a merged image. <b>J,</b> MCF7 cells expressing specific NYESO1 antigen were pretreated with vehicle (DMSO), fulvestrant (10 nmol/L), birinapant (100 nmol/L), and the combination of both drugs and cocultured with primary NYESO1 TCR⁺ T cells for 16 hours. The number of cancer cells alive was measured, and data are relative to MCF7_NYESO1 grown without T cells. *, <i>P</i> < 0.05; ***, <i>P</i> < 0.001; n.s., not significant. Error bars are mean ± SD of at least three replicates. Two-way ANOVA.</p>" @default.
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• W4387260037 date "2023-10-02" @default.
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• W4387260037 title "Figure 7 from Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer" @default.
• W4387260037 doi "https://doi.org/10.1158/0008-5472.24229138" @default.
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