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- W4387260083 abstract "To investigate the longitudinal association between preconception and prenatal alcohol exposure (PAE) and fetal growth, with a focus on timing and amount of PAE. The Safe Passage Study is a prospective cohort study of 1698 pregnant women. During pregnancy, two-dimensional transabdominal ultrasounds were repeatedly used to measure biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL). Estimated fetal weight (EFW) and z-scores of all growth parameters were calculated. PAE was assessed with the timeline follow back method. Two linear mixed models were built: one with alcohol exposure as accumulative variable, and one trimester-specific model. Preconception and prenatal alcohol exposure were both associated with reduced fetal growth. Figure 1 shows the estimated z-scores and corresponding 95% confidence intervals of exposed fetuses and controls. PAE, as an accumulative measure, was related to a shorter FL and a smaller AC. Preconception alcohol exposure was related to a smaller AC and a lower EFW. Second trimester PAE was related to a smaller AC and EFW, while third trimester exposure was related to a shorter FL. This study showed that PAE negatively affects fetal growth, particularly when exposed during the last menstrual period, second trimester and during third trimester. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
- W4387260083 created "2023-10-03" @default.
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- W4387260083 date "2023-10-01" @default.
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- W4387260083 title "EP15.03: Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study" @default.
- W4387260083 doi "https://doi.org/10.1002/uog.26872" @default.
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