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- W4387260251 abstract "The amniotic cavity develops at around 7 weeks of gestation and is visible on transvaginal ultrasound. No studies have examined the normal distribution of amniotic sac measurements and whether falling outside the 5th or 95th centile is associated with an abnormal pregnancy. The aim of this study is to develop a reference interval for amniotic sac dimensions in live normally sited (eutopic) pregnancies between 7-9+6 weeks of gestation. This was a prospective cohort study of women who attended our Early Pregnancy Unit and underwent a transvaginal ultrasound scan. We recruited 20 women per every week between 7 to 9+6 weeks of gestation (total of 60) who were diagnosed with normally sited live pregnancies and the Crown–rump length (CRL) corresponding to their certain menstrual dates. All women also had normal findings on a follow-up scan at 12-14 weeks of gestation. The mean gestation sac diameter (GSD) and the mean amniotic sac diameter (ASD) were calculated as the average of 3 perpendicular diameters with the callipers placed at the inner edges of the trophoblast for GSD and inner edges of the amniotic membrane for ASD. We calculated GSD to ASD ratio. Polynomial regression analysis was used to determine inter-relationship between ASD and CRL, GSD:ASD ratio and CRL and to establish a reference interval of both with CRL. There was a significant quadratic association between ASD and CRL: R2 = 0.930, p < 0.001. There was a significant negative cubic association between GSD:AS ratio and CRL: R2 = 0.731, p < 0.01 (figure 1). There is a strong association between ASD and CRL as well as GSD:ASD ratio to CRL. We have produced a reference interval for amniotic sac measurements that we can expand and use in future practice and further research. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
- W4387260251 created "2023-10-03" @default.
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- W4387260251 date "2023-10-01" @default.
- W4387260251 modified "2023-10-18" @default.
- W4387260251 title "EP27.17: Reference interval of amniotic sac at 7–10 weeks of gestation" @default.
- W4387260251 doi "https://doi.org/10.1002/uog.27158" @default.
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