Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387261107> ?p ?o ?g. }
- W4387261107 endingPage "1708" @default.
- W4387261107 startingPage "1689" @default.
- W4387261107 abstract "Hepatocellular carcinoma (HCC) is one of the most common leading causes of cancer death worldwide. As most patients are diagnosed with advanced disease, systemic therapy remains the backbone of treatment. In recent years, we have witnessed the transformation of advanced HCC treatment landscapes from single-agent targeted therapies to immunotherapy combinations, with atezolizumab plus bevacizumab becoming the new first-line standard of care with an increase in overall survival, progression-free survival, and objective response rate compared to sorafenib, and a positive impact on quality of life. Although the efficacy and safety of this combination have been confirmed regardless of ethnicity, age, and etiology, only a subgroup of patients seems to benefit the most from this treatment. Currently, predictive serum and tissue biomarkers to select patients who are most likely to respond to atezolizumab plus bevacizumab are lacking. Moreover, the optimal subsequent therapy for patients who progress on first-line atezolizumab plus bevacizumab remains unknown, clinical trials are ongoing, and real-world data are needed to determine the most effective treatment sequence. Importantly, careful evaluation of bleeding risk and preservation of adequate liver function are fundamental to improve patients' prognosis, especially when subsequent treatments are administered." @default.
- W4387261107 created "2023-10-03" @default.
- W4387261107 creator A5013417150 @default.
- W4387261107 creator A5065803904 @default.
- W4387261107 creator A5082329452 @default.
- W4387261107 creator A5003778423 @default.
- W4387261107 creator A5030334411 @default.
- W4387261107 date "2023-10-01" @default.
- W4387261107 modified "2023-10-11" @default.
- W4387261107 title "Safety and Efficacy of Atezolizumab and Bevacizumab Combination as a First Line Treatment of Advanced Hepatocellular Carcinoma" @default.
- W4387261107 cites W1971837077 @default.
- W4387261107 cites W1994193851 @default.
- W4387261107 cites W2019607817 @default.
- W4387261107 cites W2079586464 @default.
- W4387261107 cites W2101571970 @default.
- W4387261107 cites W2560499218 @default.
- W4387261107 cites W2787358630 @default.
- W4387261107 cites W2793126547 @default.
- W4387261107 cites W2805592007 @default.
- W4387261107 cites W2809889937 @default.
- W4387261107 cites W2908573150 @default.
- W4387261107 cites W2938499540 @default.
- W4387261107 cites W2975405931 @default.
- W4387261107 cites W2990602950 @default.
- W4387261107 cites W2998980069 @default.
- W4387261107 cites W3025022288 @default.
- W4387261107 cites W3032646207 @default.
- W4387261107 cites W3033218405 @default.
- W4387261107 cites W3041755538 @default.
- W4387261107 cites W3088665227 @default.
- W4387261107 cites W3090413519 @default.
- W4387261107 cites W3094496272 @default.
- W4387261107 cites W3095867890 @default.
- W4387261107 cites W3121497974 @default.
- W4387261107 cites W3123846806 @default.
- W4387261107 cites W3128927131 @default.
- W4387261107 cites W3131552574 @default.
- W4387261107 cites W3132994416 @default.
- W4387261107 cites W3142573131 @default.
- W4387261107 cites W3157139293 @default.
- W4387261107 cites W3164409331 @default.
- W4387261107 cites W3165241302 @default.
- W4387261107 cites W3166629588 @default.
- W4387261107 cites W3166753505 @default.
- W4387261107 cites W3168166128 @default.
- W4387261107 cites W3173947248 @default.
- W4387261107 cites W3180754516 @default.
- W4387261107 cites W3186127018 @default.
- W4387261107 cites W3196593048 @default.
- W4387261107 cites W3203118406 @default.
- W4387261107 cites W3209037065 @default.
- W4387261107 cites W3212192415 @default.
- W4387261107 cites W3213277274 @default.
- W4387261107 cites W3215011445 @default.
- W4387261107 cites W4200158019 @default.
- W4387261107 cites W4200388794 @default.
- W4387261107 cites W4205460569 @default.
- W4387261107 cites W4205751629 @default.
- W4387261107 cites W4205890422 @default.
- W4387261107 cites W4206373649 @default.
- W4387261107 cites W4206656883 @default.
- W4387261107 cites W4210281213 @default.
- W4387261107 cites W4220787479 @default.
- W4387261107 cites W4220929644 @default.
- W4387261107 cites W4220963560 @default.
- W4387261107 cites W4223902617 @default.
- W4387261107 cites W4225090163 @default.
- W4387261107 cites W4226196287 @default.
- W4387261107 cites W4226360696 @default.
- W4387261107 cites W4283325186 @default.
- W4387261107 cites W4283812631 @default.
- W4387261107 cites W4285393111 @default.
- W4387261107 cites W4285745791 @default.
- W4387261107 cites W4290927695 @default.
- W4387261107 cites W4292444180 @default.
- W4387261107 cites W4292814190 @default.
- W4387261107 cites W4294838953 @default.
- W4387261107 cites W4296797531 @default.
- W4387261107 cites W4297498619 @default.
- W4387261107 cites W4297986221 @default.
- W4387261107 cites W4300690634 @default.
- W4387261107 cites W4302029115 @default.
- W4387261107 cites W4304175321 @default.
- W4387261107 cites W4306685677 @default.
- W4387261107 cites W4306909876 @default.
- W4387261107 cites W4307645826 @default.
- W4387261107 cites W4310069342 @default.
- W4387261107 cites W4310082966 @default.
- W4387261107 cites W4310172261 @default.
- W4387261107 cites W4310183164 @default.
- W4387261107 cites W4310228491 @default.
- W4387261107 cites W4310595719 @default.
- W4387261107 cites W4310699927 @default.
- W4387261107 cites W4310756190 @default.
- W4387261107 cites W4317892064 @default.
- W4387261107 cites W4318904055 @default.
- W4387261107 cites W4318904059 @default.
- W4387261107 cites W4321190475 @default.