Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387262132> ?p ?o ?g. }
- W4387262132 endingPage "214" @default.
- W4387262132 startingPage "208" @default.
- W4387262132 abstract "Natural compounds with sulfur moiety produce various biological actions that may be beneficial for the therapies of several devastative disorders of the central nervous system. Here we investigated potential therapeutic effect of allicin, an organosulfur compound derived from garlic, in a mouse model of intracerebral hemorrhage (ICH) based on intrastriatal collagenase injection. Daily intraperitoneal administration of allicin (50 mg/kg) from 3 h after induction of ICH afforded neuroprotective effects, as evidenced by the increase of surviving neurons in the hematoma, reduction of axonal transport impairment, and prevention of axon tract injury. In addition, allicin inhibited accumulation of activated microglia/macrophages around the hematoma and infiltration of neutrophils within the hematoma. Allicin also suppressed ICH-induced mRNA upregulation of pro-inflammatory factors such as interleukin 6 and C-X-C motif ligand 2 in the brain, suggesting its anti-inflammatory effect. Moreover, ICH-induced increase of malondialdehyde as well as decrease of total glutathione in the brain was attenuated by allicin. Finally, allicin-treated mice showed better recovery of sensorimotor functions after ICH than vehicle-treated mice. These results indicate that allicin produces a therapeutic effect on ICH pathology via alleviation of neuronal damage, inflammatory responses and oxidative stress in the brain." @default.
- W4387262132 created "2023-10-03" @default.
- W4387262132 creator A5021822498 @default.
- W4387262132 creator A5028580184 @default.
- W4387262132 creator A5045966375 @default.
- W4387262132 creator A5057339710 @default.
- W4387262132 creator A5069380651 @default.
- W4387262132 creator A5082002376 @default.
- W4387262132 creator A5089074853 @default.
- W4387262132 creator A5090255721 @default.
- W4387262132 date "2023-12-01" @default.
- W4387262132 modified "2023-10-12" @default.
- W4387262132 title "Therapeutic effect of allicin in a mouse model of intracerebral hemorrhage" @default.
- W4387262132 cites W1431292219 @default.
- W4387262132 cites W1489163539 @default.
- W4387262132 cites W1833269464 @default.
- W4387262132 cites W1845545224 @default.
- W4387262132 cites W1866068290 @default.
- W4387262132 cites W1987689427 @default.
- W4387262132 cites W1990858068 @default.
- W4387262132 cites W1993282326 @default.
- W4387262132 cites W2002502972 @default.
- W4387262132 cites W2012682445 @default.
- W4387262132 cites W2028069007 @default.
- W4387262132 cites W2060580758 @default.
- W4387262132 cites W2079108520 @default.
- W4387262132 cites W2089889911 @default.
- W4387262132 cites W2146654304 @default.
- W4387262132 cites W2564382418 @default.
- W4387262132 cites W2589191455 @default.
- W4387262132 cites W2745316227 @default.
- W4387262132 cites W2757886158 @default.
- W4387262132 cites W2767501955 @default.
- W4387262132 cites W2897909741 @default.
- W4387262132 cites W2903443808 @default.
- W4387262132 cites W2913959349 @default.
- W4387262132 cites W2955644861 @default.
- W4387262132 cites W2956706371 @default.
- W4387262132 cites W2981202354 @default.
- W4387262132 cites W3008692793 @default.
- W4387262132 cites W3009701721 @default.
- W4387262132 cites W3010632462 @default.
- W4387262132 cites W3013025666 @default.
- W4387262132 cites W3080854966 @default.
- W4387262132 cites W3165513622 @default.
- W4387262132 cites W3191346838 @default.
- W4387262132 cites W4200229119 @default.
- W4387262132 cites W4211043562 @default.
- W4387262132 cites W4212840900 @default.
- W4387262132 cites W4283311358 @default.
- W4387262132 cites W4283743596 @default.
- W4387262132 cites W4307884780 @default.
- W4387262132 cites W4308688070 @default.
- W4387262132 cites W4386002734 @default.
- W4387262132 doi "https://doi.org/10.1016/j.jphs.2023.09.007" @default.
- W4387262132 hasPublicationYear "2023" @default.
- W4387262132 type Work @default.
- W4387262132 citedByCount "0" @default.
- W4387262132 crossrefType "journal-article" @default.
- W4387262132 hasAuthorship W4387262132A5021822498 @default.
- W4387262132 hasAuthorship W4387262132A5028580184 @default.
- W4387262132 hasAuthorship W4387262132A5045966375 @default.
- W4387262132 hasAuthorship W4387262132A5057339710 @default.
- W4387262132 hasAuthorship W4387262132A5069380651 @default.
- W4387262132 hasAuthorship W4387262132A5082002376 @default.
- W4387262132 hasAuthorship W4387262132A5089074853 @default.
- W4387262132 hasAuthorship W4387262132A5090255721 @default.
- W4387262132 hasBestOaLocation W43872621321 @default.
- W4387262132 hasConcept C181199279 @default.
- W4387262132 hasConcept C185592680 @default.
- W4387262132 hasConcept C203014093 @default.
- W4387262132 hasConcept C25498285 @default.
- W4387262132 hasConcept C2776151105 @default.
- W4387262132 hasConcept C2776914184 @default.
- W4387262132 hasConcept C2777094939 @default.
- W4387262132 hasConcept C2777736543 @default.
- W4387262132 hasConcept C2778401633 @default.
- W4387262132 hasConcept C2779830541 @default.
- W4387262132 hasConcept C2781005338 @default.
- W4387262132 hasConcept C42219234 @default.
- W4387262132 hasConcept C538909803 @default.
- W4387262132 hasConcept C55493867 @default.
- W4387262132 hasConcept C71924100 @default.
- W4387262132 hasConcept C87753298 @default.
- W4387262132 hasConcept C98274493 @default.
- W4387262132 hasConceptScore W4387262132C181199279 @default.
- W4387262132 hasConceptScore W4387262132C185592680 @default.
- W4387262132 hasConceptScore W4387262132C203014093 @default.
- W4387262132 hasConceptScore W4387262132C25498285 @default.
- W4387262132 hasConceptScore W4387262132C2776151105 @default.
- W4387262132 hasConceptScore W4387262132C2776914184 @default.
- W4387262132 hasConceptScore W4387262132C2777094939 @default.
- W4387262132 hasConceptScore W4387262132C2777736543 @default.
- W4387262132 hasConceptScore W4387262132C2778401633 @default.
- W4387262132 hasConceptScore W4387262132C2779830541 @default.
- W4387262132 hasConceptScore W4387262132C2781005338 @default.
- W4387262132 hasConceptScore W4387262132C42219234 @default.
- W4387262132 hasConceptScore W4387262132C538909803 @default.