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- W4387263513 abstract "To assess the utility of PlGF levels and sFlt-1/PlGF ratio in combination with Umbilical Artery Pulsatility Index (UAPI) to predict preterm birth (PTB) for infants with fetal growth restriction (FGR). Prospective cohort study of pregnancies complicated by isolated FGR (defined by Delphi consensus). Maternal serum PlGF, sFlt-1/PlGF ratio and UAPI were measured at 4-weekly intervals from recruitment and compared to appropriate-for-gestational-age controls. PlGF < 100ng/L and sFlt-1/PlGF ratio >5.78 if < 28 weeks and >38 if ≥28 weeks in combination with UAPI < 50, 50-95, < 95 and ≥95 centiles were compared to ascertain the ideal combination to predict PTB (< 37 weeks). Multivariable Cox regression was used as time-varying covariates. Of 188 pregnancies, 72 (38.3%) were FGR. UAPI and PlGF in combination had the highest predictive utility for PTB. UAPI ≥95 centile and PlGF < 100ng/L (HR 26.65, 95% CI 7.1-99.98). UAPI < 95 centile and PlGF < 100ng/L (HR 8.87,1.93-40.69). UAPI and sFlt-1/PlGF ratio in combination were also predictive of preterm birth. UAPI ≥95 centile and sFlt-1/PlGF ratio ≤5.78 or ≤38 (HR 5.20,1.25-21.71) whilst UAPI ≥95 centile and sFlt-1/PlGF ratio >5.78 or >38 (HR 9.57,2.50-36.60). UAPI < 95 centile and sFlt-1/PlGF ratio >5.78 or >38 (HR 3.92,1.21-12.76). The probability of preterm delivery within 1, 2, 3 and 4 weeks when UAPI ≥95 centile and PlGF < 100ng/L was 9.1%, 50%, 18.2% and 13.6% respectively. The probability of preterm delivery within 1, 2, 3 and 4 weeks if the UAPI ≥95 centile and raised sFlt-1/PlGF ratio was 5.9%, 41.2%, 23.5% and 11.8% respectively. UAPI ≥95 centile in combination with PlGF < 100ng/L is strongly predictive of PTB for FGR infants with the highest hazard ratios compared to UAPI ≥95 centile and sFlt-1/PlGF ratio >5.78 or >38. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
- W4387263513 created "2023-10-03" @default.
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- W4387263513 date "2023-10-01" @default.
- W4387263513 modified "2023-10-03" @default.
- W4387263513 title "EP13.06: Prediction of preterm birth for growth‐restricted infants using PlGF, sFlt‐1/PlGF ratio and umbilical artery pulsatility index in combination" @default.
- W4387263513 doi "https://doi.org/10.1002/uog.26812" @default.
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