Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387263744> ?p ?o ?g. }
- W4387263744 endingPage "4805" @default.
- W4387263744 startingPage "4805" @default.
- W4387263744 abstract "Integrins play a fundamental role in the migration and invasiveness of glioblastoma (GBM) cells, making them suitable targets for innovative cancer therapy. The aim of this study was to evaluate the effect of the RGD homodimeric disintegrin VLO4, isolated from Vipera lebetina obtusa venom, on the adhesion, spreading, migration, and survival of LBC3, LN18, and LN229 cell lines. This disintegrin, as a potent antagonist for α5β1 integrin, showed pro-adhesive properties for these cell lines, the highest for LN229 and the lowest for LBC3. Glioblastoma cells displayed significant differences in the spreading on the immobilized VLO4 and the natural α5β1 integrin ligand, fibronectin. Solubilized VLO4 showed different cytotoxicity and pro-apoptotic properties among tested cell lines, with the highest against LN18 and none against LN229. Moreover, VLO4 revealed an inhibitory effect on the migration of LBC3 and LN18 cell lines, in contrast to LN229 cells, which were not sensitive to this disintegrin. However, LN229 migration was impaired by VLO5, a disintegrin antagonistic to integrin α9β1, used in combination with VLO4. A possible mechanism of action of VLO4 may be related to the downregulation of α5β1 integrin subunit expression, as revealed by Western blot. VLO4 also inhibited cell proliferation and induced caspase-dependent apoptosis in LBC3 and LN18 cell lines. These results indicate that targeting α5β1 integrin by related VLO4 compounds may be useful in the development of integrin-targeted therapy for glioblastoma." @default.
- W4387263744 created "2023-10-03" @default.
- W4387263744 creator A5017936056 @default.
- W4387263744 creator A5035116582 @default.
- W4387263744 creator A5045851752 @default.
- W4387263744 creator A5059761115 @default.
- W4387263744 date "2023-09-29" @default.
- W4387263744 modified "2023-10-17" @default.
- W4387263744 title "Effect of Dimeric Disintegrins Isolated from Vipera lebetina obtusa Venom on Glioblastoma Cellular Responses" @default.
- W4387263744 cites W1547644303 @default.
- W4387263744 cites W1634476601 @default.
- W4387263744 cites W1921145068 @default.
- W4387263744 cites W1965434058 @default.
- W4387263744 cites W1969522550 @default.
- W4387263744 cites W1977122455 @default.
- W4387263744 cites W1983997975 @default.
- W4387263744 cites W1989448848 @default.
- W4387263744 cites W1990376658 @default.
- W4387263744 cites W2019097505 @default.
- W4387263744 cites W2021973314 @default.
- W4387263744 cites W2024292436 @default.
- W4387263744 cites W2035023695 @default.
- W4387263744 cites W2036998931 @default.
- W4387263744 cites W2045292924 @default.
- W4387263744 cites W2054536623 @default.
- W4387263744 cites W2072397543 @default.
- W4387263744 cites W2080866550 @default.
- W4387263744 cites W2084925759 @default.
- W4387263744 cites W2096287682 @default.
- W4387263744 cites W2117993491 @default.
- W4387263744 cites W2118868562 @default.
- W4387263744 cites W2148977460 @default.
- W4387263744 cites W2161287613 @default.
- W4387263744 cites W2257147234 @default.
- W4387263744 cites W2271878625 @default.
- W4387263744 cites W2335711161 @default.
- W4387263744 cites W2503601304 @default.
- W4387263744 cites W2623959190 @default.
- W4387263744 cites W2750074602 @default.
- W4387263744 cites W2898874164 @default.
- W4387263744 cites W2900253262 @default.
- W4387263744 cites W2940610523 @default.
- W4387263744 cites W3003319709 @default.
- W4387263744 cites W3011370684 @default.
- W4387263744 cites W3041110488 @default.
- W4387263744 cites W3086939937 @default.
- W4387263744 cites W3115177595 @default.
- W4387263744 cites W3132558808 @default.
- W4387263744 cites W3153769500 @default.
- W4387263744 cites W3155289023 @default.
- W4387263744 cites W3174246647 @default.
- W4387263744 cites W3210578434 @default.
- W4387263744 cites W4200327950 @default.
- W4387263744 cites W4210837388 @default.
- W4387263744 cites W4243385699 @default.
- W4387263744 cites W4243913524 @default.
- W4387263744 cites W4251025034 @default.
- W4387263744 cites W4292466520 @default.
- W4387263744 cites W4297498039 @default.
- W4387263744 cites W4309331387 @default.
- W4387263744 cites W4313433602 @default.
- W4387263744 cites W4364375137 @default.
- W4387263744 cites W4366494054 @default.
- W4387263744 cites W4380301033 @default.
- W4387263744 cites W4385421979 @default.
- W4387263744 cites W4385769333 @default.
- W4387263744 doi "https://doi.org/10.3390/cancers15194805" @default.
- W4387263744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37835499" @default.
- W4387263744 hasPublicationYear "2023" @default.
- W4387263744 type Work @default.
- W4387263744 citedByCount "0" @default.
- W4387263744 crossrefType "journal-article" @default.
- W4387263744 hasAuthorship W4387263744A5017936056 @default.
- W4387263744 hasAuthorship W4387263744A5035116582 @default.
- W4387263744 hasAuthorship W4387263744A5045851752 @default.
- W4387263744 hasAuthorship W4387263744A5059761115 @default.
- W4387263744 hasBestOaLocation W43872637441 @default.
- W4387263744 hasConcept C109523444 @default.
- W4387263744 hasConcept C1491633281 @default.
- W4387263744 hasConcept C153911025 @default.
- W4387263744 hasConcept C185592680 @default.
- W4387263744 hasConcept C195687474 @default.
- W4387263744 hasConcept C2778259572 @default.
- W4387263744 hasConcept C2779358239 @default.
- W4387263744 hasConcept C2779448229 @default.
- W4387263744 hasConcept C502942594 @default.
- W4387263744 hasConcept C54355233 @default.
- W4387263744 hasConcept C55493867 @default.
- W4387263744 hasConcept C55728118 @default.
- W4387263744 hasConcept C81885089 @default.
- W4387263744 hasConcept C85789140 @default.
- W4387263744 hasConcept C86492073 @default.
- W4387263744 hasConcept C86803240 @default.
- W4387263744 hasConcept C95444343 @default.
- W4387263744 hasConceptScore W4387263744C109523444 @default.
- W4387263744 hasConceptScore W4387263744C1491633281 @default.
- W4387263744 hasConceptScore W4387263744C153911025 @default.
- W4387263744 hasConceptScore W4387263744C185592680 @default.