Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387266979> ?p ?o ?g. }
- W4387266979 abstract "Traditional prognostic models for newly diagnosed patients with multiple myeloma (MM), including International Staging System criteria and number of high-risk chromosomal abnormalities, are based on disease characteristics at diagnosis. However, the identification of patients at risk of more rapidly progressive MM is inherently a dynamic assessment. In a subset of patients with MM, adverse disease biology only becomes evident after the failure of first-line therapy. We define this entity as functional high-risk MM (FHRMM), encompassing relapse within 18 months of treatment initiation and/or within 12 months of frontline autologous stem cell transplantation. FHRMM is not adequately captured by traditional prognostic models, and there is a need for better understanding of mechanisms or risk factors for early relapse or progression. In this review, we explore potential definitions of FHRMM before delving into its underlying drivers based on genetic, transcriptomic, and immune cell profiling studies. Emerging data suggest that specific features of both myeloma cells and immune cells can enable the FHRMM phenotype. We conclude our review by discussing ongoing and future studies that seek to identify and intervene upon patients with FHRMM preemptively." @default.
- W4387266979 created "2023-10-03" @default.
- W4387266979 creator A5020076602 @default.
- W4387266979 creator A5022331310 @default.
- W4387266979 creator A5024384857 @default.
- W4387266979 creator A5089585044 @default.
- W4387266979 date "2023-10-02" @default.
- W4387266979 modified "2023-10-03" @default.
- W4387266979 title "Definers and drivers of functional high-risk multiple myeloma: insights from genomic, transcriptomic, and immune profiling" @default.
- W4387266979 cites W1518359110 @default.
- W4387266979 cites W1903203537 @default.
- W4387266979 cites W1965557074 @default.
- W4387266979 cites W1977328011 @default.
- W4387266979 cites W1986297232 @default.
- W4387266979 cites W1989238658 @default.
- W4387266979 cites W2001006211 @default.
- W4387266979 cites W2004291080 @default.
- W4387266979 cites W2004333717 @default.
- W4387266979 cites W2016453634 @default.
- W4387266979 cites W2052311590 @default.
- W4387266979 cites W2074995740 @default.
- W4387266979 cites W2092725609 @default.
- W4387266979 cites W2095162291 @default.
- W4387266979 cites W2117005724 @default.
- W4387266979 cites W2128192762 @default.
- W4387266979 cites W2137345333 @default.
- W4387266979 cites W2164295529 @default.
- W4387266979 cites W2207976342 @default.
- W4387266979 cites W2273653207 @default.
- W4387266979 cites W2293830167 @default.
- W4387266979 cites W2395837508 @default.
- W4387266979 cites W2602650330 @default.
- W4387266979 cites W2604936103 @default.
- W4387266979 cites W2605974076 @default.
- W4387266979 cites W2723461124 @default.
- W4387266979 cites W2727539324 @default.
- W4387266979 cites W2753882619 @default.
- W4387266979 cites W2762805663 @default.
- W4387266979 cites W2766219238 @default.
- W4387266979 cites W2774700270 @default.
- W4387266979 cites W2788630550 @default.
- W4387266979 cites W2789906913 @default.
- W4387266979 cites W2790364994 @default.
- W4387266979 cites W2879746793 @default.
- W4387266979 cites W2887488342 @default.
- W4387266979 cites W2889058133 @default.
- W4387266979 cites W2897079850 @default.
- W4387266979 cites W2905233176 @default.
- W4387266979 cites W2948728876 @default.
- W4387266979 cites W2956888684 @default.
- W4387266979 cites W2962324833 @default.
- W4387266979 cites W2968650703 @default.
- W4387266979 cites W2991596906 @default.
- W4387266979 cites W2996431522 @default.
- W4387266979 cites W3004055029 @default.
- W4387266979 cites W3004485101 @default.
- W4387266979 cites W3006525893 @default.
- W4387266979 cites W3006717022 @default.
- W4387266979 cites W3011070604 @default.
- W4387266979 cites W3013575560 @default.
- W4387266979 cites W3019889711 @default.
- W4387266979 cites W3022711082 @default.
- W4387266979 cites W3034037943 @default.
- W4387266979 cites W3038884302 @default.
- W4387266979 cites W3039727831 @default.
- W4387266979 cites W3044605664 @default.
- W4387266979 cites W3094613554 @default.
- W4387266979 cites W3095166474 @default.
- W4387266979 cites W3099114602 @default.
- W4387266979 cites W3115638785 @default.
- W4387266979 cites W3115962838 @default.
- W4387266979 cites W3124391571 @default.
- W4387266979 cites W3133229959 @default.
- W4387266979 cites W3133251387 @default.
- W4387266979 cites W3133399993 @default.
- W4387266979 cites W3135406304 @default.
- W4387266979 cites W3135629194 @default.
- W4387266979 cites W3138416708 @default.
- W4387266979 cites W3139986620 @default.
- W4387266979 cites W3148884749 @default.
- W4387266979 cites W3158314482 @default.
- W4387266979 cites W3164224366 @default.
- W4387266979 cites W3180522082 @default.
- W4387266979 cites W3196847582 @default.
- W4387266979 cites W3203429737 @default.
- W4387266979 cites W3211102840 @default.
- W4387266979 cites W3211625813 @default.
- W4387266979 cites W3214247274 @default.
- W4387266979 cites W3214646447 @default.
- W4387266979 cites W3217436926 @default.
- W4387266979 cites W4200312283 @default.
- W4387266979 cites W4200360295 @default.
- W4387266979 cites W4206541189 @default.
- W4387266979 cites W4207000127 @default.
- W4387266979 cites W4210499394 @default.
- W4387266979 cites W4210738494 @default.
- W4387266979 cites W4213448829 @default.
- W4387266979 cites W4223930219 @default.
- W4387266979 cites W4225943158 @default.
- W4387266979 cites W4281559367 @default.