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- W4387268081 abstract "Abstract Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases." @default.
- W4387268081 created "2023-10-03" @default.
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- W4387268081 date "2023-10-02" @default.
- W4387268081 modified "2023-10-14" @default.
- W4387268081 title "Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases" @default.
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- W4387268081 doi "https://doi.org/10.1038/s41467-023-41783-9" @default.
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