Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387270140> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4387270140 abstract "Vein graft failure (VGF) occurs in 20-40% of coronary and lower extremity bypasses within the first-year secondary to intimal hyperplasia. Despite previous work identifying the key genomic responses associated with implantation injury, the complex signaling pathways and biomolecular identities at the cellular and spatial levels have yet to be elucidated. We utilized integrated single-nuclei and spatial transcriptomics analysis to investigate the pathologic response to vein graft injury that occurs at 24hr after implantation of an autogenous cephalic vein in a canine carotid artery interposition bypass model. We identified upregulation of specific genes, including FNDC3B and VCAN, which have been implicated in smooth muscle cell (SMC) dysfunction, vascular injury and atherosclerosis, and downregulation of AHNAK, a gene known to promote vascular healing and accelerate re-endothelization (Figure 1). Interestingly, our spatial transcriptomics analysis revealed that the response to injury does not occur in a circumferential pattern in the vein graft. Genes associated with vascular dysfunction were more highly expressed in a distinct area of the graft that comprises approximately 25% of the entire circumference, representing a site of tear or mechanical injury. This area had a differential decrease in SMCs and increase in monocyte/macrophages compared to the remaining regions of the graft. These results highlight the feasibility and importance of single nuclei and spatial integrated analysis in understanding tissue architecture as well as genomic changes following vein graft implantation, to ultimately help identify novel targets for therapeutic intervention." @default.
- W4387270140 created "2023-10-03" @default.
- W4387270140 creator A5002810884 @default.
- W4387270140 creator A5010474293 @default.
- W4387270140 creator A5015773089 @default.
- W4387270140 creator A5027818431 @default.
- W4387270140 creator A5040053329 @default.
- W4387270140 creator A5053854117 @default.
- W4387270140 creator A5060522857 @default.
- W4387270140 creator A5061451648 @default.
- W4387270140 creator A5063480560 @default.
- W4387270140 creator A5078870255 @default.
- W4387270140 creator A5085135258 @default.
- W4387270140 creator A5092989547 @default.
- W4387270140 date "2023-05-01" @default.
- W4387270140 modified "2023-10-03" @default.
- W4387270140 title "Abstract 429: Integrating Single-nuclei And Spatial Transcriptome Analysis To Identify Early Injury Pathways Following Arterial Venous Bypass" @default.
- W4387270140 doi "https://doi.org/10.1161/atvb.43.suppl_1.429" @default.
- W4387270140 hasPublicationYear "2023" @default.
- W4387270140 type Work @default.
- W4387270140 citedByCount "0" @default.
- W4387270140 crossrefType "journal-article" @default.
- W4387270140 hasAuthorship W4387270140A5002810884 @default.
- W4387270140 hasAuthorship W4387270140A5010474293 @default.
- W4387270140 hasAuthorship W4387270140A5015773089 @default.
- W4387270140 hasAuthorship W4387270140A5027818431 @default.
- W4387270140 hasAuthorship W4387270140A5040053329 @default.
- W4387270140 hasAuthorship W4387270140A5053854117 @default.
- W4387270140 hasAuthorship W4387270140A5060522857 @default.
- W4387270140 hasAuthorship W4387270140A5061451648 @default.
- W4387270140 hasAuthorship W4387270140A5063480560 @default.
- W4387270140 hasAuthorship W4387270140A5078870255 @default.
- W4387270140 hasAuthorship W4387270140A5085135258 @default.
- W4387270140 hasAuthorship W4387270140A5092989547 @default.
- W4387270140 hasConcept C104317684 @default.
- W4387270140 hasConcept C126322002 @default.
- W4387270140 hasConcept C127561419 @default.
- W4387270140 hasConcept C141071460 @default.
- W4387270140 hasConcept C142724271 @default.
- W4387270140 hasConcept C150194340 @default.
- W4387270140 hasConcept C162317418 @default.
- W4387270140 hasConcept C164705383 @default.
- W4387270140 hasConcept C2776820930 @default.
- W4387270140 hasConcept C2777202286 @default.
- W4387270140 hasConcept C2779395532 @default.
- W4387270140 hasConcept C2779751240 @default.
- W4387270140 hasConcept C2992686903 @default.
- W4387270140 hasConcept C55493867 @default.
- W4387270140 hasConcept C71924100 @default.
- W4387270140 hasConcept C86803240 @default.
- W4387270140 hasConceptScore W4387270140C104317684 @default.
- W4387270140 hasConceptScore W4387270140C126322002 @default.
- W4387270140 hasConceptScore W4387270140C127561419 @default.
- W4387270140 hasConceptScore W4387270140C141071460 @default.
- W4387270140 hasConceptScore W4387270140C142724271 @default.
- W4387270140 hasConceptScore W4387270140C150194340 @default.
- W4387270140 hasConceptScore W4387270140C162317418 @default.
- W4387270140 hasConceptScore W4387270140C164705383 @default.
- W4387270140 hasConceptScore W4387270140C2776820930 @default.
- W4387270140 hasConceptScore W4387270140C2777202286 @default.
- W4387270140 hasConceptScore W4387270140C2779395532 @default.
- W4387270140 hasConceptScore W4387270140C2779751240 @default.
- W4387270140 hasConceptScore W4387270140C2992686903 @default.
- W4387270140 hasConceptScore W4387270140C55493867 @default.
- W4387270140 hasConceptScore W4387270140C71924100 @default.
- W4387270140 hasConceptScore W4387270140C86803240 @default.
- W4387270140 hasIssue "Suppl_1" @default.
- W4387270140 hasLocation W43872701401 @default.
- W4387270140 hasOpenAccess W4387270140 @default.
- W4387270140 hasPrimaryLocation W43872701401 @default.
- W4387270140 hasRelatedWork W1977794018 @default.
- W4387270140 hasRelatedWork W2041526299 @default.
- W4387270140 hasRelatedWork W2065721005 @default.
- W4387270140 hasRelatedWork W2110809908 @default.
- W4387270140 hasRelatedWork W2120914990 @default.
- W4387270140 hasRelatedWork W2354575854 @default.
- W4387270140 hasRelatedWork W2357990663 @default.
- W4387270140 hasRelatedWork W2369179617 @default.
- W4387270140 hasRelatedWork W2927082434 @default.
- W4387270140 hasRelatedWork W2952771499 @default.
- W4387270140 hasVolume "43" @default.
- W4387270140 isParatext "false" @default.
- W4387270140 isRetracted "false" @default.
- W4387270140 workType "article" @default.