Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387270265> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4387270265 abstract "Increased prevalence of obesity in the US continues to drive greater risk for developing type 2 diabetes and cardiovascular disease. Excessive caloric intake stresses adipocytes into storing lipid in an unhealthy manner, directing lipid into existing adipocytes, or adipocyte hypertrophy. Healthy adipose tissue expansion and remodeling occurs when adipose tissue precursor cells (PC) in the stromal vascular fraction (SVF) differentiate to create new pre-adipocytes which store lipid, called hyperplasia. Single cell sequencing of visceral adipose tissue (VAT) have identified two main types of PCs in the SVF, one called adipocyte precursor cells (APCs), while the other is a fibro-inflammatory progenitors (FIPs). APC are pre-adipocytes which given the proper signals, differentiate into mature adipocytes, while FIPs, can secrete cytokines inhibiting APC differentiation and initiating inflammation. Also influencing APC and FIP lineage in the SVF are the transforming growth factor beta (TGFb)-like signaling pathways which inhibit adipogenesis, while bone morphogenetic protein (BMP)-like signaling promotes adipogenesis. Little is known about how signaling through these pathways alters APCs and FIPs fate, especially during increased lipoprotein flux from high fat diet (HFD). Recently we discovered that both VAT PCs, APCs and FIPs express high levels of the extracellular matrix (ECM) protein, procollagen endopeptidase enhancer protein 2 (Pcpe2 ) whose expression decreases as APCs become committed adipocytes. We found that Pcpe2 is significantly up-regulated ~4-fold by TGFb1 suggesting that Pcpe2 plays a role in TGFb-like pathways in VAT PCs. Using PC-specific Pcpe2-hemagglutinin tagged (HA) overexpressor (ox) (PC-Pcpe oxHA ) and PC cell-specific Pcpe2 knockout (KO) (PC-Pcpe2 KO ) mice lines, studies show PC-Pcpe2 KO mice have reduced (~35-40%) body and VAT weight, while PC-Pcpe oxHA mice showed an increase (~40-45%) in body and VAT weight, characterized by hypertrophic adipocytes. In other studies we show APC rates of proliferation and differentiation are highly dependent on Pcpe2 expression. Overall, these studies reveal novel mechanistic insight into the mechanisms involved in dysfunctional fat storage." @default.
- W4387270265 created "2023-10-03" @default.
- W4387270265 creator A5012217431 @default.
- W4387270265 creator A5031249980 @default.
- W4387270265 creator A5057087105 @default.
- W4387270265 date "2023-05-01" @default.
- W4387270265 modified "2023-10-03" @default.
- W4387270265 title "Abstract 448: Role Of Pcpe2 In Adipose Tissue Remodeling And Lipoprotein Metabolism" @default.
- W4387270265 doi "https://doi.org/10.1161/atvb.43.suppl_1.448" @default.
- W4387270265 hasPublicationYear "2023" @default.
- W4387270265 type Work @default.
- W4387270265 citedByCount "0" @default.
- W4387270265 crossrefType "journal-article" @default.
- W4387270265 hasAuthorship W4387270265A5012217431 @default.
- W4387270265 hasAuthorship W4387270265A5031249980 @default.
- W4387270265 hasAuthorship W4387270265A5057087105 @default.
- W4387270265 hasConcept C122927707 @default.
- W4387270265 hasConcept C126322002 @default.
- W4387270265 hasConcept C134018914 @default.
- W4387270265 hasConcept C151955695 @default.
- W4387270265 hasConcept C16930146 @default.
- W4387270265 hasConcept C171089720 @default.
- W4387270265 hasConcept C17675752 @default.
- W4387270265 hasConcept C25095133 @default.
- W4387270265 hasConcept C2776175234 @default.
- W4387270265 hasConcept C2780745355 @default.
- W4387270265 hasConcept C71924100 @default.
- W4387270265 hasConcept C86803240 @default.
- W4387270265 hasConcept C95444343 @default.
- W4387270265 hasConceptScore W4387270265C122927707 @default.
- W4387270265 hasConceptScore W4387270265C126322002 @default.
- W4387270265 hasConceptScore W4387270265C134018914 @default.
- W4387270265 hasConceptScore W4387270265C151955695 @default.
- W4387270265 hasConceptScore W4387270265C16930146 @default.
- W4387270265 hasConceptScore W4387270265C171089720 @default.
- W4387270265 hasConceptScore W4387270265C17675752 @default.
- W4387270265 hasConceptScore W4387270265C25095133 @default.
- W4387270265 hasConceptScore W4387270265C2776175234 @default.
- W4387270265 hasConceptScore W4387270265C2780745355 @default.
- W4387270265 hasConceptScore W4387270265C71924100 @default.
- W4387270265 hasConceptScore W4387270265C86803240 @default.
- W4387270265 hasConceptScore W4387270265C95444343 @default.
- W4387270265 hasIssue "Suppl_1" @default.
- W4387270265 hasLocation W43872702651 @default.
- W4387270265 hasOpenAccess W4387270265 @default.
- W4387270265 hasPrimaryLocation W43872702651 @default.
- W4387270265 hasRelatedWork W1997621688 @default.
- W4387270265 hasRelatedWork W2027098794 @default.
- W4387270265 hasRelatedWork W2118746168 @default.
- W4387270265 hasRelatedWork W2228231544 @default.
- W4387270265 hasRelatedWork W2297285928 @default.
- W4387270265 hasRelatedWork W2793894193 @default.
- W4387270265 hasRelatedWork W2800722771 @default.
- W4387270265 hasRelatedWork W3135655817 @default.
- W4387270265 hasRelatedWork W4377086953 @default.
- W4387270265 hasRelatedWork W2493639187 @default.
- W4387270265 hasVolume "43" @default.
- W4387270265 isParatext "false" @default.
- W4387270265 isRetracted "false" @default.
- W4387270265 workType "article" @default.