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- W4387270277 abstract "Introduction: Perceived high bleeding risk is the primary reason for withholding anticoagulation (AC) in patients with atrial fibrillation (AF). We performed AF-ALERT 2, a randomized controlled trial (RCT) of alert-based computerized decision support (CDS), to increase AC prescription in high-risk outpatients with AF. Method: We analyzed 397 patients in the alert group of this trial to determine the clinical characteristics and outcomes of patients. 77 patients perceived as having too high risk of bleeding were compared with 320 patients with perceived low bleeding risk. Results: Perceived high bleeding risk was the main reason providers omitted AC (19.3%). Patients with high bleeding risk were 36.4% women and had a mean age of 78. Median of CHA 2 DS 2 VASc and HAS-BLED were similar in patients with high and low bleeding risk (median (IQR) 4(2-7) vs 3(2-8) and median (IQR) 3(2-5) vs 3(1-5), respectively) (Figure). Higher median HAS-BLED was associated with higher rates of clinically relevant non-major bleeding (CRNMB) ( p =0.03). Patients with perceived high and low bleeding risk received similar rates of AC at 90 days (14.3% vs 18.4%, p =0.44). Major and CRNMB rates were similar between the two groups. Conclusion: In a trial of alert-based CDS, perceived bleeding risk was the most common reason for omitting AC prescriptions in patients with AF. Despite having similar median HAS-BLED, patients with perceived high bleeding risk had similar rates of AC prescription to those deemed low bleeding risk." @default.
- W4387270277 created "2023-10-03" @default.
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- W4387270277 date "2023-05-01" @default.
- W4387270277 modified "2023-10-03" @default.
- W4387270277 title "Abstract 598: Patients With High Bleeding Risk In A Randomized Controlled Trial Of Alert-based Computerized Decision Support For Stroke Prevention In Atrial Fibrillation: An AF-ALERT II Substudy" @default.
- W4387270277 doi "https://doi.org/10.1161/atvb.43.suppl_1.598" @default.
- W4387270277 hasPublicationYear "2023" @default.
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