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- W4387293872 abstract "How our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. Using Drosophila lamina neurons (L1-L5), we show that the homeodomain transcription factor (HDTF) Brain-specific homeobox (Bsh) is initiated in progenitors and maintained in L4/L5 neurons to adulthood. Bsh specifies L4/L5 fate by activating HDTFs Ap (L4) and Pdm3 (L5) and repressing the HDTF Zfh1 to prevent ectopic L1/L3 fate, thereby generating lamina neuronal diversity. Subsequently, Bsh and Ap function in a feed-forward loop within postmitotic L4 neurons to activate the synapse recognition molecule DIP-β, thereby specifying synaptic connectivity. Expression of a Bsh:Dam fusion specifically in L4 reveals Bsh binding to the DIP-β locus and candidate L4 functional identity genes. We propose that HDTFs function hierarchically to coordinate neuronal molecular identity, circuit formation, and function. Hierarchical HDTFs may represent a conserved mechanism for linking neuronal diversity to circuit assembly and function." @default.
- W4387293872 created "2023-10-03" @default.
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- W4387293872 date "2023-10-02" @default.
- W4387293872 modified "2023-10-04" @default.
- W4387293872 title "Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity" @default.
- W4387293872 doi "https://doi.org/10.7554/elife.90133.1" @default.
- W4387293872 hasPublicationYear "2023" @default.
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