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- W4387296409 abstract "Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant-derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti-PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound-drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl-isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti-PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d-limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high-quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa." @default.
- W4387296409 created "2023-10-04" @default.
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- W4387296409 date "2023-10-02" @default.
- W4387296409 modified "2023-10-18" @default.
- W4387296409 title "The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities" @default.
- W4387296409 cites W136863196 @default.
- W4387296409 cites W1480357432 @default.
- W4387296409 cites W1550830253 @default.
- W4387296409 cites W1570552217 @default.
- W4387296409 cites W1573024086 @default.
- W4387296409 cites W1597813032 @default.
- W4387296409 cites W1612799591 @default.
- W4387296409 cites W1802523704 @default.
- W4387296409 cites W1832527043 @default.
- W4387296409 cites W185057651 @default.
- W4387296409 cites W1889558574 @default.
- W4387296409 cites W1893283179 @default.
- W4387296409 cites W1923564765 @default.
- W4387296409 cites W1952352960 @default.
- W4387296409 cites W1964950171 @default.
- W4387296409 cites W1967190009 @default.
- W4387296409 cites W1967402893 @default.
- W4387296409 cites W1967601023 @default.
- W4387296409 cites W1968486553 @default.
- W4387296409 cites W1969400185 @default.
- W4387296409 cites W1970062306 @default.
- W4387296409 cites W1970428333 @default.
- W4387296409 cites W1972881374 @default.
- W4387296409 cites W1974949211 @default.
- W4387296409 cites W1978397479 @default.
- W4387296409 cites W1980347598 @default.
- W4387296409 cites W1984143603 @default.
- W4387296409 cites W1984178593 @default.
- W4387296409 cites W1984234527 @default.
- W4387296409 cites W1984358846 @default.
- W4387296409 cites W1985307249 @default.
- W4387296409 cites W1985753549 @default.
- W4387296409 cites W1986256291 @default.
- W4387296409 cites W1990090167 @default.
- W4387296409 cites W1991327193 @default.
- W4387296409 cites W1992527837 @default.
- W4387296409 cites W1992828890 @default.
- W4387296409 cites W1994271777 @default.
- W4387296409 cites W1995753424 @default.
- W4387296409 cites W1995995955 @default.
- W4387296409 cites W1996038316 @default.
- W4387296409 cites W1996385848 @default.
- W4387296409 cites W1997149430 @default.
- W4387296409 cites W1997379399 @default.
- W4387296409 cites W1998084113 @default.
- W4387296409 cites W1998646491 @default.
- W4387296409 cites W2001268142 @default.
- W4387296409 cites W2005084937 @default.
- W4387296409 cites W2005411204 @default.
- W4387296409 cites W2005529246 @default.
- W4387296409 cites W2006302849 @default.
- W4387296409 cites W2006676149 @default.
- W4387296409 cites W2006736903 @default.
- W4387296409 cites W2007215401 @default.
- W4387296409 cites W2007499788 @default.
- W4387296409 cites W2008214241 @default.
- W4387296409 cites W2012589659 @default.
- W4387296409 cites W2013372525 @default.
- W4387296409 cites W2013611824 @default.
- W4387296409 cites W2013875639 @default.
- W4387296409 cites W2014221264 @default.
- W4387296409 cites W2016424446 @default.
- W4387296409 cites W2016771357 @default.
- W4387296409 cites W2018320862 @default.
- W4387296409 cites W2019463551 @default.
- W4387296409 cites W2019518392 @default.
- W4387296409 cites W2019608011 @default.
- W4387296409 cites W2021312876 @default.
- W4387296409 cites W2022741388 @default.
- W4387296409 cites W2024405339 @default.
- W4387296409 cites W2024738814 @default.
- W4387296409 cites W2027379193 @default.
- W4387296409 cites W2027583643 @default.
- W4387296409 cites W2028897202 @default.
- W4387296409 cites W2029074172 @default.
- W4387296409 cites W2030104903 @default.
- W4387296409 cites W2030768658 @default.
- W4387296409 cites W2030834429 @default.
- W4387296409 cites W2031171659 @default.
- W4387296409 cites W2031848367 @default.