FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387296411> ?p ?o ?g. }

• W4387296411 abstract "Pancreatic cancer (PC) is among the most lethal cancers. The lack of effective tools for early detection results in late tumor detection and, consequently, high mortality rate. Precision oncology aims to develop targeted individual treatments based on advanced computational approaches of omics data. Biomarkers, such as global alteration of cytosine (CpG) methylation, can be pivotal for these objectives. In this study, we performed DNA methylation profiling of pancreatic cancer patients using circulating cell-free DNA (cfDNA) and artificial intelligence (AI) including Deep Learning (DL) for minimally invasive detection to elucidate the epigenetic pathogenesis of PC.The Illumina Infinium HD Assay was used for genome-wide DNA methylation profiling of cfDNA in treatment-naïve patients. Six AI algorithms were used to determine PC detection accuracy based on cytosine (CpG) methylation markers. Additional strategies for minimizing overfitting were employed. The molecular pathogenesis was interrogated using enrichment analysis.In total, we identified 4556 significantly differentially methylated CpGs (q-value < 0.05; Bonferroni correction) in PC versus controls. Highly accurate PC detection was achieved with all 6 AI platforms (Area under the receiver operator characteristics curve [0.90-1.00]). For example, DL achieved AUC (95% CI): 1.00 (0.95-1.00), with a sensitivity and specificity of 100%. A separate modeling approach based on logistic regression-based yielded an AUC (95% CI) 1.0 (1.0-1.0) with a sensitivity and specificity of 100% for PC detection. The top four biological pathways that were epigenetically altered in PC and are known to be linked with cancer are discussed.Using a minimally invasive approach, AI, and epigenetic analysis of circulating cfDNA, high predictive accuracy for PC was achieved. From a clinical perspective, our findings suggest that that early detection leading to improved overall survival may be achievable in the future." @default.
• W4387296411 created "2023-10-04" @default.
• W4387296411 creator A5028145109 @default.
• W4387296411 creator A5035646450 @default.
• W4387296411 creator A5059256534 @default.
• W4387296411 creator A5080969604 @default.
• W4387296411 date "2023-10-03" @default.
• W4387296411 modified "2023-10-04" @default.
• W4387296411 title "Precision oncology: Artificial intelligence, circulating cell‐free DNA, and the minimally invasive detection of pancreatic cancer—A pilot study" @default.
• W4387296411 cites W1966001391 @default.
• W4387296411 cites W1982185581 @default.
• W4387296411 cites W1989816222 @default.
• W4387296411 cites W2051292461 @default.
• W4387296411 cites W2060427373 @default.
• W4387296411 cites W2117911065 @default.
• W4387296411 cites W2129024581 @default.
• W4387296411 cites W2135607659 @default.
• W4387296411 cites W2141224543 @default.
• W4387296411 cites W2155988062 @default.
• W4387296411 cites W2306606423 @default.
• W4387296411 cites W2344385257 @default.
• W4387296411 cites W2385968901 @default.
• W4387296411 cites W2469106569 @default.
• W4387296411 cites W2549852019 @default.
• W4387296411 cites W2592760610 @default.
• W4387296411 cites W2593831845 @default.
• W4387296411 cites W2604779289 @default.
• W4387296411 cites W2767582147 @default.
• W4387296411 cites W2767806813 @default.
• W4387296411 cites W2787693916 @default.
• W4387296411 cites W2809279418 @default.
• W4387296411 cites W2894315454 @default.
• W4387296411 cites W2894736184 @default.
• W4387296411 cites W2903074934 @default.
• W4387296411 cites W2917919815 @default.
• W4387296411 cites W2941891803 @default.
• W4387296411 cites W2962974300 @default.
• W4387296411 cites W2970409529 @default.
• W4387296411 cites W2980402901 @default.
• W4387296411 cites W3015319505 @default.
• W4387296411 cites W3044331820 @default.
• W4387296411 cites W3047080531 @default.
• W4387296411 cites W3048358590 @default.
• W4387296411 cites W3049642946 @default.
• W4387296411 cites W3096828292 @default.
• W4387296411 cites W3107820751 @default.
• W4387296411 cites W3115858378 @default.
• W4387296411 cites W3139518338 @default.
• W4387296411 cites W3159995035 @default.
• W4387296411 cites W3162742754 @default.
• W4387296411 cites W3176719936 @default.
• W4387296411 cites W3177064219 @default.
• W4387296411 cites W3184406026 @default.
• W4387296411 cites W3192866502 @default.
• W4387296411 cites W3193452811 @default.
• W4387296411 cites W3193483009 @default.
• W4387296411 cites W3197296839 @default.
• W4387296411 cites W3216340627 @default.
• W4387296411 cites W3216626421 @default.
• W4387296411 cites W4220752485 @default.
• W4387296411 cites W4225379489 @default.
• W4387296411 cites W4225702738 @default.
• W4387296411 cites W4225716729 @default.
• W4387296411 cites W4283360345 @default.
• W4387296411 cites W4283703721 @default.
• W4387296411 cites W4284896464 @default.
• W4387296411 cites W4285733522 @default.
• W4387296411 cites W4290375489 @default.
• W4387296411 cites W4307740620 @default.
• W4387296411 cites W4308099569 @default.
• W4387296411 cites W4319222175 @default.
• W4387296411 doi "https://doi.org/10.1002/cam4.6604" @default.
• W4387296411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37787018" @default.
• W4387296411 hasPublicationYear "2023" @default.
• W4387296411 type Work @default.
• W4387296411 citedByCount "0" @default.
• W4387296411 crossrefType "journal-article" @default.
• W4387296411 hasAuthorship W4387296411A5028145109 @default.
• W4387296411 hasAuthorship W4387296411A5035646450 @default.
• W4387296411 hasAuthorship W4387296411A5059256534 @default.
• W4387296411 hasAuthorship W4387296411A5080969604 @default.
• W4387296411 hasBestOaLocation W43872964111 @default.
• W4387296411 hasConcept C104317684 @default.
• W4387296411 hasConcept C121608353 @default.
• W4387296411 hasConcept C121912465 @default.
• W4387296411 hasConcept C126322002 @default.
• W4387296411 hasConcept C140173407 @default.
• W4387296411 hasConcept C142724271 @default.
• W4387296411 hasConcept C143998085 @default.
• W4387296411 hasConcept C150194340 @default.
• W4387296411 hasConcept C152110520 @default.
• W4387296411 hasConcept C163763905 @default.
• W4387296411 hasConcept C172680121 @default.
• W4387296411 hasConcept C190727270 @default.
• W4387296411 hasConcept C2778258057 @default.
• W4387296411 hasConcept C2779234561 @default.
• W4387296411 hasConcept C2779529041 @default.
• W4387296411 hasConcept C2780210213 @default.
• W4387296411 hasConcept C33288867 @default.
• W4387296411 hasConcept C41091548 @default.

• next