FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387296495> ?p ?o ?g. }

• W4387296495 endingPage "168295" @default.
• W4387296495 startingPage "168295" @default.
• W4387296495 abstract "A variety of biological roles of mechanical forces have been proposed in cell biology, such as cell signaling pathways for survival, development, growth, and differentiation. Mechanical forces alter the mechanical conditions within cells and their environment, which strongly influences the reorganization of the actin cytoskeleton. Single-molecule imaging studies of actin filaments have led to the hypothesis that the actin filament acts as a mechanosensor; e.g., increases in actin filament tension alter their conformation and affinity for regulatory proteins. However, our understanding of the molecular mechanisms underlying how tension modulates the mechanical behavior of a single actin filament is still incomplete. In this study, a direct measurement of the twisting and bending of a fluorescently labeled single actin filament under different tension levels by force application (0.8–3.4 pN) was performed using single-molecule fluorescence polarization (SMFP) microscopy. The results showed that the amplitude of twisting and bending fluctuations of a single actin filament decreased with increasing tension. Electron micrograph analysis of tensed filaments also revealed that the fluctuations in the crossover length of actin filaments decreased with increasing filament tension. Possible molecular mechanisms underlying these results involving the binding of actin-binding proteins, such as cofilin, to the filament are discussed." @default.
• W4387296495 created "2023-10-04" @default.
• W4387296495 creator A5002211336 @default.
• W4387296495 creator A5054722414 @default.
• W4387296495 creator A5057692964 @default.
• W4387296495 creator A5058058056 @default.
• W4387296495 date "2023-11-01" @default.
• W4387296495 modified "2023-10-12" @default.
• W4387296495 title "Mechanical Stress Decreases the Amplitude of Twisting and Bending Fluctuations of Actin Filaments" @default.
• W4387296495 cites W1966086467 @default.
• W4387296495 cites W1967944317 @default.
• W4387296495 cites W1977926556 @default.
• W4387296495 cites W1988535937 @default.
• W4387296495 cites W1992348310 @default.
• W4387296495 cites W2000168038 @default.
• W4387296495 cites W2000936608 @default.
• W4387296495 cites W2009453532 @default.
• W4387296495 cites W2012507357 @default.
• W4387296495 cites W2013594557 @default.
• W4387296495 cites W2020081859 @default.
• W4387296495 cites W2020149988 @default.
• W4387296495 cites W2023772919 @default.
• W4387296495 cites W2025930425 @default.
• W4387296495 cites W2027901151 @default.
• W4387296495 cites W2029036023 @default.
• W4387296495 cites W2031439529 @default.
• W4387296495 cites W2035195047 @default.
• W4387296495 cites W2041039705 @default.
• W4387296495 cites W2055601386 @default.
• W4387296495 cites W2058096164 @default.
• W4387296495 cites W2061062548 @default.
• W4387296495 cites W2062053844 @default.
• W4387296495 cites W2066353854 @default.
• W4387296495 cites W2068971883 @default.
• W4387296495 cites W2071102178 @default.
• W4387296495 cites W2082067280 @default.
• W4387296495 cites W2087977758 @default.
• W4387296495 cites W2101430971 @default.
• W4387296495 cites W2105082854 @default.
• W4387296495 cites W2107324974 @default.
• W4387296495 cites W2125232552 @default.
• W4387296495 cites W2125495005 @default.
• W4387296495 cites W2127820234 @default.
• W4387296495 cites W2128994323 @default.
• W4387296495 cites W2134208433 @default.
• W4387296495 cites W2136535147 @default.
• W4387296495 cites W2139229287 @default.
• W4387296495 cites W2149374899 @default.
• W4387296495 cites W2169952714 @default.
• W4387296495 cites W2171355873 @default.
• W4387296495 cites W2800497993 @default.
• W4387296495 cites W2804270214 @default.
• W4387296495 cites W2892194155 @default.
• W4387296495 cites W2901268888 @default.
• W4387296495 cites W2909546226 @default.
• W4387296495 cites W2952730233 @default.
• W4387296495 cites W2964010851 @default.
• W4387296495 cites W3128605695 @default.
• W4387296495 cites W4307656504 @default.
• W4387296495 cites W4317480418 @default.
• W4387296495 cites W4318764069 @default.
• W4387296495 doi "https://doi.org/10.1016/j.jmb.2023.168295" @default.
• W4387296495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37783285" @default.
• W4387296495 hasPublicationYear "2023" @default.
• W4387296495 type Work @default.
• W4387296495 citedByCount "0" @default.
• W4387296495 crossrefType "journal-article" @default.
• W4387296495 hasAuthorship W4387296495A5002211336 @default.
• W4387296495 hasAuthorship W4387296495A5054722414 @default.
• W4387296495 hasAuthorship W4387296495A5057692964 @default.
• W4387296495 hasAuthorship W4387296495A5058058056 @default.
• W4387296495 hasBestOaLocation W43872964951 @default.
• W4387296495 hasConcept C112950240 @default.
• W4387296495 hasConcept C120665830 @default.
• W4387296495 hasConcept C121332964 @default.
• W4387296495 hasConcept C12554922 @default.
• W4387296495 hasConcept C125705527 @default.
• W4387296495 hasConcept C130861313 @default.
• W4387296495 hasConcept C14228908 @default.
• W4387296495 hasConcept C142669718 @default.
• W4387296495 hasConcept C1491633281 @default.
• W4387296495 hasConcept C159985019 @default.
• W4387296495 hasConcept C169274487 @default.
• W4387296495 hasConcept C185592680 @default.
• W4387296495 hasConcept C186068551 @default.
• W4387296495 hasConcept C189040839 @default.
• W4387296495 hasConcept C192562407 @default.
• W4387296495 hasConcept C2776601116 @default.
• W4387296495 hasConcept C2993400109 @default.
• W4387296495 hasConcept C3620293 @default.
• W4387296495 hasConcept C55493867 @default.
• W4387296495 hasConcept C86803240 @default.
• W4387296495 hasConcept C91881484 @default.
• W4387296495 hasConceptScore W4387296495C112950240 @default.
• W4387296495 hasConceptScore W4387296495C120665830 @default.
• W4387296495 hasConceptScore W4387296495C121332964 @default.
• W4387296495 hasConceptScore W4387296495C12554922 @default.
• W4387296495 hasConceptScore W4387296495C125705527 @default.

• next