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- W4387296645 abstract "Abstract Background Mechanical and morphological factors have both been described to influence the rate of pseudarthrosis in mandibular reconstruction. By minimizing mechanical confounders, the present study aims to evaluate the impact of bone origin at the intersegmental gap on osseous union. Methods Patients were screened retrospectively for undergoing multi-segment fibula free flap reconstruction of the mandible including the anterior part of the mandible and osteosynthesis using patient-specific 3D-printed titanium reconstruction plates. Percentage changes in bone volume and width at the bone interface between the fibula/fibula and fibula/mandible at the anterior intersegmental gaps within the same patient were determined using cone-beam computed tomography (CBCT). Additionally, representative samples of the intersegmental zones were assessed histologically and using micro-computed tomography (µCT). Results The bone interface ( p = 0.223) did not significantly impact the change in bone volume at the intersegmental gap. Radiotherapy ( p < 0.001), time between CBCT scans ( p = 0.006) and wound healing disorders ( p = 0.005) were independent risk factors for osseous non-union. Preliminary analysis of the microstructure of the intersegmental bone did not indicate morphological differences between fibula–fibula and fibula–mandible intersegmental bones. Conclusions The bone interface at the intersegmental gap in mandibular reconstruction did not influence long-term bone healing significantly. Mechanical and clinical properties seem to be more relevant for surgical success." @default.
- W4387296645 created "2023-10-04" @default.
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- W4387296645 date "2023-10-03" @default.
- W4387296645 modified "2023-10-05" @default.
- W4387296645 title "Impact of the adjacent bone on pseudarthrosis in mandibular reconstruction with fibula free flaps" @default.
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- W4387296645 doi "https://doi.org/10.1186/s13005-023-00389-8" @default.
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