FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387296871> ?p ?o ?g. }

• W4387296871 abstract "Hypoxic Ischemic Encephalopathy (HIE) is one of the principal causes of neonatal mortality and long-term morbidity worldwide. The neonatal signs of mild cerebral injury are subtle, making an early precise diagnosis difficult. Delayed detection, poor prognosis, and lack of specific biomarkers for the disease are increasing mortality rates. In this study, we intended to identify specific biomarkers using comparative proteomic analysis to predict the severity of perinatal asphyxia so that its outcome can also be prevented.A case-control study was conducted on 38 neonates, and urine samples were collected within 24 and 72 h of life. A tandem mass spectrometry-based quantitative proteomics approach, followed by validation via sandwich ELISA, was performed.The LC-MS/MS-based proteomics analysis resulted in the identification of 1201 proteins in urine, with 229, 244, and 426 being differentially expressed in HIE-1, HIE-2, and HIE-3, respectively. Axon guidance, Diseases of programmed cell death, and Detoxification of reactive oxygen species pathways were significantly enriched in mild HIE versus severe HIE. Among the differentially expressed proteins in various stages of HIE, we chose to validate four proteins - APP, AGT, FABP1, and FN1 - via sandwich ELISA. Individual and cumulative ROC curves were plotted. AGT and FABP1 together showed high sensitivity, specificity, and accuracy as potential biomarkers for early diagnosis of HIE.Establishing putative urinary biomarkers will facilitate clinicians to more accurately screen neonates for brain injury and monitor the disease progression. Prompt treatment of neonates may reduce mortality and neurodevelopmental impairment." @default.
• W4387296871 created "2023-10-04" @default.
• W4387296871 creator A5001839988 @default.
• W4387296871 creator A5005367167 @default.
• W4387296871 creator A5010624077 @default.
• W4387296871 creator A5044106489 @default.
• W4387296871 creator A5062740392 @default.
• W4387296871 creator A5063293987 @default.
• W4387296871 creator A5070676037 @default.
• W4387296871 creator A5090240625 @default.
• W4387296871 creator A5090489290 @default.
• W4387296871 date "2023-10-03" @default.
• W4387296871 modified "2023-10-05" @default.
• W4387296871 title "A comparative proteomic analysis for non‐invasive early prediction of hypoxic‐ischemic injury in asphyxiated neonates" @default.
• W4387296871 cites W1964478993 @default.
• W4387296871 cites W2004854463 @default.
• W4387296871 cites W2027103190 @default.
• W4387296871 cites W2041939149 @default.
• W4387296871 cites W2074211480 @default.
• W4387296871 cites W2075149554 @default.
• W4387296871 cites W2090277531 @default.
• W4387296871 cites W2102507104 @default.
• W4387296871 cites W2312180445 @default.
• W4387296871 cites W2312584131 @default.
• W4387296871 cites W2330745701 @default.
• W4387296871 cites W2345356016 @default.
• W4387296871 cites W2413400904 @default.
• W4387296871 cites W2423319399 @default.
• W4387296871 cites W2429116149 @default.
• W4387296871 cites W2539260864 @default.
• W4387296871 cites W2558197048 @default.
• W4387296871 cites W2560280176 @default.
• W4387296871 cites W2567096679 @default.
• W4387296871 cites W2765707786 @default.
• W4387296871 cites W2765857420 @default.
• W4387296871 cites W2792158145 @default.
• W4387296871 cites W2900633264 @default.
• W4387296871 cites W2901879461 @default.
• W4387296871 cites W2941200958 @default.
• W4387296871 cites W2942375992 @default.
• W4387296871 cites W2946037571 @default.
• W4387296871 cites W2970118803 @default.
• W4387296871 cites W2974521039 @default.
• W4387296871 cites W2990852694 @default.
• W4387296871 cites W3009683877 @default.
• W4387296871 cites W3010004490 @default.
• W4387296871 cites W3021123623 @default.
• W4387296871 cites W3046482587 @default.
• W4387296871 cites W3087458297 @default.
• W4387296871 cites W3096371117 @default.
• W4387296871 cites W3198805454 @default.
• W4387296871 cites W4226082460 @default.
• W4387296871 cites W4324375469 @default.
• W4387296871 doi "https://doi.org/10.1002/prca.202200054" @default.
• W4387296871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37787895" @default.
• W4387296871 hasPublicationYear "2023" @default.
• W4387296871 type Work @default.
• W4387296871 citedByCount "0" @default.
• W4387296871 crossrefType "journal-article" @default.
• W4387296871 hasAuthorship W4387296871A5001839988 @default.
• W4387296871 hasAuthorship W4387296871A5005367167 @default.
• W4387296871 hasAuthorship W4387296871A5010624077 @default.
• W4387296871 hasAuthorship W4387296871A5044106489 @default.
• W4387296871 hasAuthorship W4387296871A5062740392 @default.
• W4387296871 hasAuthorship W4387296871A5063293987 @default.
• W4387296871 hasAuthorship W4387296871A5070676037 @default.
• W4387296871 hasAuthorship W4387296871A5090240625 @default.
• W4387296871 hasAuthorship W4387296871A5090489290 @default.
• W4387296871 hasConcept C104317684 @default.
• W4387296871 hasConcept C126322002 @default.
• W4387296871 hasConcept C187212893 @default.
• W4387296871 hasConcept C2778080812 @default.
• W4387296871 hasConcept C2778621155 @default.
• W4387296871 hasConcept C2779134260 @default.
• W4387296871 hasConcept C2779914510 @default.
• W4387296871 hasConcept C2780026642 @default.
• W4387296871 hasConcept C2780164069 @default.
• W4387296871 hasConcept C2909832856 @default.
• W4387296871 hasConcept C46111723 @default.
• W4387296871 hasConcept C55493867 @default.
• W4387296871 hasConcept C60644358 @default.
• W4387296871 hasConcept C71924100 @default.
• W4387296871 hasConcept C86803240 @default.
• W4387296871 hasConceptScore W4387296871C104317684 @default.
• W4387296871 hasConceptScore W4387296871C126322002 @default.
• W4387296871 hasConceptScore W4387296871C187212893 @default.
• W4387296871 hasConceptScore W4387296871C2778080812 @default.
• W4387296871 hasConceptScore W4387296871C2778621155 @default.
• W4387296871 hasConceptScore W4387296871C2779134260 @default.
• W4387296871 hasConceptScore W4387296871C2779914510 @default.
• W4387296871 hasConceptScore W4387296871C2780026642 @default.
• W4387296871 hasConceptScore W4387296871C2780164069 @default.
• W4387296871 hasConceptScore W4387296871C2909832856 @default.
• W4387296871 hasConceptScore W4387296871C46111723 @default.
• W4387296871 hasConceptScore W4387296871C55493867 @default.
• W4387296871 hasConceptScore W4387296871C60644358 @default.
• W4387296871 hasConceptScore W4387296871C71924100 @default.
• W4387296871 hasConceptScore W4387296871C86803240 @default.
• W4387296871 hasFunder F4320320720 @default.
• W4387296871 hasLocation W43872968711 @default.

• next