FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387296919> ?p ?o ?g. }

• W4387296919 abstract "Transmural action potential duration differences and transmural conduction gradients aid the synchronization of left ventricular repolarization, reducing vulnerability to transmural reentry and arrhythmias. A high-fat diet and the associated accumulation of pericardial adipose tissue are linked with conduction slowing and greater arrhythmia vulnerability. It is predicted that cardiac adiposity may more readily influence epicardial conduction (versus endocardial) and disrupt normal transmural activation/repolarization gradients. The aim of this investigation was to determine whether transmural conduction gradients are modified in a rat model of pericardial adiposity. Adult Sprague-Dawley rats were fed control/high-fat diets for 15 wk. Left ventricular 300 µm tangential slices were generated from the endocardium to the epicardium, and conduction was mapped using microelectrode arrays. Slices were then histologically processed to assess fibrosis and cardiomyocyte lipid status. Conduction velocity was significantly greater in epicardial versus endocardial slices in control rats, supporting the concept of a transmural conduction gradient. High-fat diet feeding increased pericardial adiposity and abolished the transmural conduction gradient. Slowed epicardial conduction in epicardial slices strongly correlated with an increase in cardiomyocyte lipid content, but not fibrosis. The positive transmural conduction gradient reported here represents a physiological property of the ventricular activation sequence that likely protects against reentry. The absence of this gradient, secondary to conduction slowing and cardiomyocyte lipid accumulation, specifically in the epicardium, indicates a novel mechanism by which pericardial adiposity may exacerbate ventricular arrhythmias." @default.
• W4387296919 created "2023-10-04" @default.
• W4387296919 creator A5001867113 @default.
• W4387296919 creator A5002868834 @default.
• W4387296919 creator A5012918166 @default.
• W4387296919 creator A5024193805 @default.
• W4387296919 creator A5031892904 @default.
• W4387296919 creator A5042509268 @default.
• W4387296919 creator A5047325459 @default.
• W4387296919 creator A5051880045 @default.
• W4387296919 creator A5061546231 @default.
• W4387296919 creator A5067159924 @default.
• W4387296919 creator A5075142028 @default.
• W4387296919 date "2023-10-03" @default.
• W4387296919 modified "2023-10-16" @default.
• W4387296919 title "Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats" @default.
• W4387296919 cites W1526447302 @default.
• W4387296919 cites W1735188324 @default.
• W4387296919 cites W1784628723 @default.
• W4387296919 cites W1839892005 @default.
• W4387296919 cites W1978070535 @default.
• W4387296919 cites W1985578759 @default.
• W4387296919 cites W1995281013 @default.
• W4387296919 cites W2009490006 @default.
• W4387296919 cites W2055460639 @default.
• W4387296919 cites W2069325547 @default.
• W4387296919 cites W2072821264 @default.
• W4387296919 cites W2098267336 @default.
• W4387296919 cites W2105265053 @default.
• W4387296919 cites W2113362144 @default.
• W4387296919 cites W2118530283 @default.
• W4387296919 cites W2129179042 @default.
• W4387296919 cites W2152533263 @default.
• W4387296919 cites W2156055934 @default.
• W4387296919 cites W2160477565 @default.
• W4387296919 cites W2186961124 @default.
• W4387296919 cites W2227767486 @default.
• W4387296919 cites W2412507083 @default.
• W4387296919 cites W2548541194 @default.
• W4387296919 cites W2574877024 @default.
• W4387296919 cites W2773300367 @default.
• W4387296919 cites W2799394887 @default.
• W4387296919 cites W2800833147 @default.
• W4387296919 cites W2806524607 @default.
• W4387296919 cites W2808892522 @default.
• W4387296919 cites W2834256961 @default.
• W4387296919 cites W2901009239 @default.
• W4387296919 cites W2938650418 @default.
• W4387296919 cites W2952312336 @default.
• W4387296919 cites W2982640060 @default.
• W4387296919 cites W3082984518 @default.
• W4387296919 cites W3152705473 @default.
• W4387296919 cites W3206605043 @default.
• W4387296919 cites W3209904437 @default.
• W4387296919 cites W794906032 @default.
• W4387296919 doi "https://doi.org/10.1085/jgp.202213296" @default.
• W4387296919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37787979" @default.
• W4387296919 hasPublicationYear "2023" @default.
• W4387296919 type Work @default.
• W4387296919 citedByCount "0" @default.
• W4387296919 crossrefType "journal-article" @default.
• W4387296919 hasAuthorship W4387296919A5001867113 @default.
• W4387296919 hasAuthorship W4387296919A5002868834 @default.
• W4387296919 hasAuthorship W4387296919A5012918166 @default.
• W4387296919 hasAuthorship W4387296919A5024193805 @default.
• W4387296919 hasAuthorship W4387296919A5031892904 @default.
• W4387296919 hasAuthorship W4387296919A5042509268 @default.
• W4387296919 hasAuthorship W4387296919A5047325459 @default.
• W4387296919 hasAuthorship W4387296919A5051880045 @default.
• W4387296919 hasAuthorship W4387296919A5061546231 @default.
• W4387296919 hasAuthorship W4387296919A5067159924 @default.
• W4387296919 hasAuthorship W4387296919A5075142028 @default.
• W4387296919 hasConcept C104397207 @default.
• W4387296919 hasConcept C126322002 @default.
• W4387296919 hasConcept C134018914 @default.
• W4387296919 hasConcept C146403970 @default.
• W4387296919 hasConcept C159985019 @default.
• W4387296919 hasConcept C164705383 @default.
• W4387296919 hasConcept C171089720 @default.
• W4387296919 hasConcept C172100665 @default.
• W4387296919 hasConcept C179253579 @default.
• W4387296919 hasConcept C185263204 @default.
• W4387296919 hasConcept C185592680 @default.
• W4387296919 hasConcept C192562407 @default.
• W4387296919 hasConcept C2777720157 @default.
• W4387296919 hasConcept C2778875491 @default.
• W4387296919 hasConcept C2780040984 @default.
• W4387296919 hasConcept C71924100 @default.
• W4387296919 hasConcept C85378888 @default.
• W4387296919 hasConceptScore W4387296919C104397207 @default.
• W4387296919 hasConceptScore W4387296919C126322002 @default.
• W4387296919 hasConceptScore W4387296919C134018914 @default.
• W4387296919 hasConceptScore W4387296919C146403970 @default.
• W4387296919 hasConceptScore W4387296919C159985019 @default.
• W4387296919 hasConceptScore W4387296919C164705383 @default.
• W4387296919 hasConceptScore W4387296919C171089720 @default.
• W4387296919 hasConceptScore W4387296919C172100665 @default.
• W4387296919 hasConceptScore W4387296919C179253579 @default.
• W4387296919 hasConceptScore W4387296919C185263204 @default.
• W4387296919 hasConceptScore W4387296919C185592680 @default.

• next