Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387298684> ?p ?o ?g. }
- W4387298684 abstract "Disulfide bonds are widely found in natural peptides and play a pivotal role in stabilizing their secondary structures, which are highly associated with their biological functions. Herein, we introduce a light-mediated strategy to effectively control the formation of disulfides. Our strategy is based on 2-nitroveratryl (oNv), a widely used photolabile motif, which serves both as a photocaging group and an oxidant (after photolysis). We demonstrated that irradiation of oNv-caged thiols with UV light could release free thiols that are rapidly oxidized by locally released byproduct nitrosoarene, leading to a “break-to-bond” fashion. This strategy is highlighted by the in situ restoration of the antimicrobial peptide tachyplesin I (TPI) from its external disulfide-caged analogue TPI-1. TPI-1 exhibits a distorted structure and a diminished function. However, upon irradiation, the β-hairpin structure and membrane activity of TPI were largely restored via rapid intramolecular disulfide formation. Our study proposes a powerful method to regulate the conformation and function of peptides in a spatiotemporal manner, which has significant potential for the design of disulfide-centered light-responsive systems." @default.
- W4387298684 created "2023-10-04" @default.
- W4387298684 creator A5004967295 @default.
- W4387298684 creator A5016324588 @default.
- W4387298684 creator A5022342350 @default.
- W4387298684 creator A5041624099 @default.
- W4387298684 creator A5056711906 @default.
- W4387298684 creator A5059624153 @default.
- W4387298684 creator A5060933241 @default.
- W4387298684 creator A5067029768 @default.
- W4387298684 creator A5074679533 @default.
- W4387298684 creator A5077146057 @default.
- W4387298684 creator A5088165302 @default.
- W4387298684 date "2023-10-03" @default.
- W4387298684 modified "2023-10-05" @default.
- W4387298684 title "Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides" @default.
- W4387298684 cites W1508119641 @default.
- W4387298684 cites W1525157964 @default.
- W4387298684 cites W1605534350 @default.
- W4387298684 cites W1971237729 @default.
- W4387298684 cites W1972027206 @default.
- W4387298684 cites W1979504081 @default.
- W4387298684 cites W2009259298 @default.
- W4387298684 cites W2018400595 @default.
- W4387298684 cites W2039601641 @default.
- W4387298684 cites W2042947617 @default.
- W4387298684 cites W2078434863 @default.
- W4387298684 cites W2094270058 @default.
- W4387298684 cites W2114162092 @default.
- W4387298684 cites W2121697537 @default.
- W4387298684 cites W2125160663 @default.
- W4387298684 cites W2141482709 @default.
- W4387298684 cites W2149162946 @default.
- W4387298684 cites W2151558925 @default.
- W4387298684 cites W2155478771 @default.
- W4387298684 cites W2161753540 @default.
- W4387298684 cites W2255183564 @default.
- W4387298684 cites W2317417725 @default.
- W4387298684 cites W2324067768 @default.
- W4387298684 cites W2324331568 @default.
- W4387298684 cites W2332146149 @default.
- W4387298684 cites W2417122937 @default.
- W4387298684 cites W2460702558 @default.
- W4387298684 cites W2486390728 @default.
- W4387298684 cites W2489302011 @default.
- W4387298684 cites W2760639581 @default.
- W4387298684 cites W2766509651 @default.
- W4387298684 cites W2795719384 @default.
- W4387298684 cites W2799611299 @default.
- W4387298684 cites W2805808442 @default.
- W4387298684 cites W2809015206 @default.
- W4387298684 cites W2896286509 @default.
- W4387298684 cites W2906030729 @default.
- W4387298684 cites W2912058239 @default.
- W4387298684 cites W2944460251 @default.
- W4387298684 cites W2951794355 @default.
- W4387298684 cites W2981495295 @default.
- W4387298684 cites W3085523068 @default.
- W4387298684 cites W3093008333 @default.
- W4387298684 cites W3127847757 @default.
- W4387298684 cites W3129289758 @default.
- W4387298684 cites W3152285307 @default.
- W4387298684 cites W3153307819 @default.
- W4387298684 cites W3158193076 @default.
- W4387298684 cites W3177800246 @default.
- W4387298684 cites W3185100232 @default.
- W4387298684 cites W3194866316 @default.
- W4387298684 cites W3200251690 @default.
- W4387298684 cites W3210255109 @default.
- W4387298684 cites W4210484271 @default.
- W4387298684 cites W4220725552 @default.
- W4387298684 cites W4281696076 @default.
- W4387298684 cites W4307479752 @default.
- W4387298684 cites W4309865325 @default.
- W4387298684 cites W4310961090 @default.
- W4387298684 cites W4313401670 @default.
- W4387298684 cites W4315703053 @default.
- W4387298684 cites W4365814761 @default.
- W4387298684 cites W4382502553 @default.
- W4387298684 doi "https://doi.org/10.1021/jacs.3c07795" @default.
- W4387298684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37788450" @default.
- W4387298684 hasPublicationYear "2023" @default.
- W4387298684 type Work @default.
- W4387298684 citedByCount "0" @default.
- W4387298684 crossrefType "journal-article" @default.
- W4387298684 hasAuthorship W4387298684A5004967295 @default.
- W4387298684 hasAuthorship W4387298684A5016324588 @default.
- W4387298684 hasAuthorship W4387298684A5022342350 @default.
- W4387298684 hasAuthorship W4387298684A5041624099 @default.
- W4387298684 hasAuthorship W4387298684A5056711906 @default.
- W4387298684 hasAuthorship W4387298684A5059624153 @default.
- W4387298684 hasAuthorship W4387298684A5060933241 @default.
- W4387298684 hasAuthorship W4387298684A5067029768 @default.
- W4387298684 hasAuthorship W4387298684A5074679533 @default.
- W4387298684 hasAuthorship W4387298684A5077146057 @default.
- W4387298684 hasAuthorship W4387298684A5088165302 @default.
- W4387298684 hasConcept C12554922 @default.
- W4387298684 hasConcept C132677234 @default.
- W4387298684 hasConcept C185592680 @default.
- W4387298684 hasConcept C21951064 @default.