Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387300006> ?p ?o ?g. }
- W4387300006 abstract "Abstract Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD." @default.
- W4387300006 created "2023-10-04" @default.
- W4387300006 creator A5000083928 @default.
- W4387300006 creator A5001537697 @default.
- W4387300006 creator A5002118289 @default.
- W4387300006 creator A5002628021 @default.
- W4387300006 creator A5005356862 @default.
- W4387300006 creator A5005928542 @default.
- W4387300006 creator A5006266874 @default.
- W4387300006 creator A5008405084 @default.
- W4387300006 creator A5008536461 @default.
- W4387300006 creator A5008700238 @default.
- W4387300006 creator A5009975789 @default.
- W4387300006 creator A5010147421 @default.
- W4387300006 creator A5010859262 @default.
- W4387300006 creator A5011953626 @default.
- W4387300006 creator A5015522761 @default.
- W4387300006 creator A5015711180 @default.
- W4387300006 creator A5016043879 @default.
- W4387300006 creator A5017050709 @default.
- W4387300006 creator A5017305005 @default.
- W4387300006 creator A5018394889 @default.
- W4387300006 creator A5018751073 @default.
- W4387300006 creator A5020615555 @default.
- W4387300006 creator A5022368369 @default.
- W4387300006 creator A5022403410 @default.
- W4387300006 creator A5023024313 @default.
- W4387300006 creator A5023657211 @default.
- W4387300006 creator A5026370697 @default.
- W4387300006 creator A5026517521 @default.
- W4387300006 creator A5026728831 @default.
- W4387300006 creator A5026977854 @default.
- W4387300006 creator A5027599458 @default.
- W4387300006 creator A5028727426 @default.
- W4387300006 creator A5028999046 @default.
- W4387300006 creator A5029433360 @default.
- W4387300006 creator A5029835725 @default.
- W4387300006 creator A5031084817 @default.
- W4387300006 creator A5031125536 @default.
- W4387300006 creator A5031402912 @default.
- W4387300006 creator A5034083293 @default.
- W4387300006 creator A5034534740 @default.
- W4387300006 creator A5035417742 @default.
- W4387300006 creator A5035459587 @default.
- W4387300006 creator A5036568477 @default.
- W4387300006 creator A5038738280 @default.
- W4387300006 creator A5040864683 @default.
- W4387300006 creator A5040920640 @default.
- W4387300006 creator A5041397944 @default.
- W4387300006 creator A5041866909 @default.
- W4387300006 creator A5043863759 @default.
- W4387300006 creator A5045000319 @default.
- W4387300006 creator A5045585209 @default.
- W4387300006 creator A5046528295 @default.
- W4387300006 creator A5046853647 @default.
- W4387300006 creator A5048178738 @default.
- W4387300006 creator A5048210607 @default.
- W4387300006 creator A5048877098 @default.
- W4387300006 creator A5048937331 @default.
- W4387300006 creator A5049343832 @default.
- W4387300006 creator A5049569257 @default.
- W4387300006 creator A5050401635 @default.
- W4387300006 creator A5050515785 @default.
- W4387300006 creator A5051214459 @default.
- W4387300006 creator A5051850972 @default.
- W4387300006 creator A5052280527 @default.
- W4387300006 creator A5052673298 @default.
- W4387300006 creator A5053412190 @default.
- W4387300006 creator A5053853143 @default.
- W4387300006 creator A5054181336 @default.
- W4387300006 creator A5054861340 @default.
- W4387300006 creator A5056517698 @default.
- W4387300006 creator A5057103026 @default.
- W4387300006 creator A5058528330 @default.
- W4387300006 creator A5059063200 @default.
- W4387300006 creator A5059158920 @default.
- W4387300006 creator A5060317032 @default.
- W4387300006 creator A5060982659 @default.
- W4387300006 creator A5061703839 @default.
- W4387300006 creator A5061926369 @default.
- W4387300006 creator A5062357041 @default.
- W4387300006 creator A5063161038 @default.
- W4387300006 creator A5063763690 @default.
- W4387300006 creator A5063823796 @default.
- W4387300006 creator A5064278484 @default.
- W4387300006 creator A5064423707 @default.
- W4387300006 creator A5064741640 @default.
- W4387300006 creator A5064779022 @default.
- W4387300006 creator A5065109317 @default.
- W4387300006 creator A5065441923 @default.
- W4387300006 creator A5065627043 @default.
- W4387300006 creator A5065632375 @default.
- W4387300006 creator A5065675756 @default.
- W4387300006 creator A5066849166 @default.
- W4387300006 creator A5067999904 @default.
- W4387300006 creator A5068068147 @default.
- W4387300006 creator A5069696785 @default.
- W4387300006 creator A5070087897 @default.
- W4387300006 creator A5071319331 @default.
- W4387300006 creator A5073008240 @default.