Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387300549> ?p ?o ?g. }
- W4387300549 abstract "Abstract Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to test the contribution of the prefrontal endogenous opioid system to the antidepressant-like effects of a single dose of ketamine. Both the behavioral actions of ketamine and their molecular correlates in the medial prefrontal cortex (mPFC) were blocked by acute systemic administration of naltrexone, a competitive opioid receptor antagonist. Naltrexone delivered directly into the mPFC similarly disrupted the behavioral effects of ketamine. Ketamine treatment rapidly increased levels of β-endorphin and the expression of the µ-opioid receptor gene ( Oprm1 ) in the mPFC, and the expression of the gene that encodes proopiomelanocortin, the precursor of β-endorphin, in the hypothalamus, in vivo . Finally, neutralization of β-endorphin in the mPFC using a specific antibody prior to ketamine treatment abolished both behavioral and molecular effects. Together, these findings indicate that presence of β-endorphin and activation of opioid receptors in the mPFC are required for the antidepressant-like actions of ketamine." @default.
- W4387300549 created "2023-10-04" @default.
- W4387300549 creator A5048132486 @default.
- W4387300549 creator A5061506307 @default.
- W4387300549 creator A5085016374 @default.
- W4387300549 creator A5087594298 @default.
- W4387300549 date "2023-10-03" @default.
- W4387300549 modified "2023-10-04" @default.
- W4387300549 title "The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions" @default.
- W4387300549 cites W1914381346 @default.
- W4387300549 cites W1967487877 @default.
- W4387300549 cites W1969624190 @default.
- W4387300549 cites W1970627093 @default.
- W4387300549 cites W1971671415 @default.
- W4387300549 cites W1973837127 @default.
- W4387300549 cites W1978155331 @default.
- W4387300549 cites W1981966568 @default.
- W4387300549 cites W1989163516 @default.
- W4387300549 cites W1989672525 @default.
- W4387300549 cites W1993135690 @default.
- W4387300549 cites W1994642201 @default.
- W4387300549 cites W1997230063 @default.
- W4387300549 cites W1997355334 @default.
- W4387300549 cites W2000321144 @default.
- W4387300549 cites W2006381038 @default.
- W4387300549 cites W2013675509 @default.
- W4387300549 cites W2014424306 @default.
- W4387300549 cites W2015292696 @default.
- W4387300549 cites W2015667982 @default.
- W4387300549 cites W2022629884 @default.
- W4387300549 cites W2023081218 @default.
- W4387300549 cites W2025968814 @default.
- W4387300549 cites W2030594327 @default.
- W4387300549 cites W2032739515 @default.
- W4387300549 cites W2033103016 @default.
- W4387300549 cites W2035312998 @default.
- W4387300549 cites W2042894971 @default.
- W4387300549 cites W2044709062 @default.
- W4387300549 cites W2045683461 @default.
- W4387300549 cites W2046201837 @default.
- W4387300549 cites W2047804695 @default.
- W4387300549 cites W2048292955 @default.
- W4387300549 cites W2051529627 @default.
- W4387300549 cites W2053557807 @default.
- W4387300549 cites W2071743614 @default.
- W4387300549 cites W2076101724 @default.
- W4387300549 cites W2085146257 @default.
- W4387300549 cites W2089351762 @default.
- W4387300549 cites W2091645164 @default.
- W4387300549 cites W2095088615 @default.
- W4387300549 cites W2098743730 @default.
- W4387300549 cites W2111704340 @default.
- W4387300549 cites W2121651624 @default.
- W4387300549 cites W2126528250 @default.
- W4387300549 cites W2131466543 @default.
- W4387300549 cites W2134458928 @default.
- W4387300549 cites W2136970102 @default.
- W4387300549 cites W2142769837 @default.
- W4387300549 cites W2142794627 @default.
- W4387300549 cites W2163646484 @default.
- W4387300549 cites W2170532212 @default.
- W4387300549 cites W2172223517 @default.
- W4387300549 cites W2291443053 @default.
- W4387300549 cites W2311776902 @default.
- W4387300549 cites W2344604487 @default.
- W4387300549 cites W2402199320 @default.
- W4387300549 cites W2411131651 @default.
- W4387300549 cites W2472629326 @default.
- W4387300549 cites W2530336098 @default.
- W4387300549 cites W2565604828 @default.
- W4387300549 cites W2618570299 @default.
- W4387300549 cites W2736483263 @default.
- W4387300549 cites W2770846762 @default.
- W4387300549 cites W2794102241 @default.
- W4387300549 cites W2810498355 @default.
- W4387300549 cites W2884446035 @default.
- W4387300549 cites W2884804526 @default.
- W4387300549 cites W2889166554 @default.
- W4387300549 cites W2894295934 @default.
- W4387300549 cites W2900449902 @default.
- W4387300549 cites W2904749524 @default.
- W4387300549 cites W2904767373 @default.
- W4387300549 cites W2908096166 @default.
- W4387300549 cites W2910925824 @default.
- W4387300549 cites W2936807256 @default.
- W4387300549 cites W2942936997 @default.
- W4387300549 cites W2970951648 @default.
- W4387300549 cites W2986499103 @default.
- W4387300549 cites W2991582092 @default.
- W4387300549 cites W3000480376 @default.
- W4387300549 cites W3033331450 @default.
- W4387300549 cites W3127451099 @default.
- W4387300549 cites W3162218953 @default.
- W4387300549 cites W3178497840 @default.
- W4387300549 cites W4200250750 @default.
- W4387300549 cites W4224243283 @default.
- W4387300549 doi "https://doi.org/10.21203/rs.3.rs-3190391/v1" @default.
- W4387300549 hasPublicationYear "2023" @default.
- W4387300549 type Work @default.
- W4387300549 citedByCount "0" @default.