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- W4387300567 abstract "Abstract Background 82 Rb PET and [ 15 O]H 2 O PET are both validated tracers for myocardical perfusion imaging but have not previously been compared clinically. During our site’s transition from 82 Rb to [ 15 O]H 2 O PET, we performed a head-to-head comparison in a mixed population with suspected ischemic heart disease. Methods A total of 37 patients referred for perfusion imaging due to suspicion of coronary stenosis were examined with both 82 Rb and [ 15 O]H 2 O PET on the same day in rest and during adenosine-induced stress. The exams were rated by two blinded readers as normal, regional ischemia, globally reduced myocardial perfusion, or myocardial scarring. For [ 15 O]H 2 O PET, regional ischemia was defined as two neighboring segments with average stress perfusion ≤ 2.3 mL/(min·g). Further, we evaluated a total perfusion deficit (TPD) of ≥ 10% as a more conservative marker of ischemia. Results [ 15 O]H 2 O PET identified more patients with regional ischemia: 17(46%) vs 9(24%), agreement: 59% corresponding to a Cohen’s kappa of .31 [95%CI .08-.53], ( P < .001). Using the more conservative TPD ≥ 10%, the agreement increased to 86% corresponding to a kappa of .62 [95%CI .33-.92], ( P = .001). For the subgroup of patients with no known heart disease ( n = 18), the agreement was 94%. Interrater agreement was 95% corresponding to a kappa of .89 [95%CI .74-1.00] ( P < .001). Conclusions In clinical transition from 82 Rb to [ 15 O]H 2 O PET, it is important to take into account the higher frequency of patients with regional ischemia detected by [ 15 O]H 2 O PET. Graphical Abstract" @default.
- W4387300567 created "2023-10-04" @default.
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- W4387300567 date "2023-10-03" @default.
- W4387300567 modified "2023-10-05" @default.
- W4387300567 title "82Rb and [15O]H2O myocardial perfusion PET imaging: a prospective head to head comparison" @default.
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- W4387300567 doi "https://doi.org/10.1007/s12350-023-03372-7" @default.
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