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- W4387301045 endingPage "113180" @default.
- W4387301045 startingPage "113180" @default.
- W4387301045 abstract "Cognate interaction between CD4+ effector memory T (TEM) cells and dendritic cells (DCs) induces innate inflammatory cytokine production, resulting in detrimental autoimmune pathology and cytokine storms. While TEM cells use tumor necrosis factor (TNF) superfamily ligands to activate DCs, whether TEM cells prompt other DC-intrinsic changes that influence the innate inflammatory response has never been investigated. We report the surprising discovery that TEM cells trigger double-strand DNA breaks via mitochondrial reactive oxygen species (ROS) production in interacting DCs. Initiation of the DNA damage response in DCs induces activation of a cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-independent, non-canonical stimulator of interferon genes (STING)-TNF receptor-associated factor 6 (TRAF6)-nuclear factor κB (NF-κB) signaling axis. Consequently, STING-deficient DCs display reduced NF-κB activation and subsequent defects in transcriptional induction and functional production of interleukin-1β (IL-1β) and IL-6 following their interaction with TEM cells. The discovery of TEM cell-induced innate inflammation through DNA damage and a non-canonical STING-NF-κB pathway presents this pathway as a potential target to alleviate T cell-driven inflammation in autoimmunity and cytokine storms." @default.
- W4387301045 created "2023-10-04" @default.
- W4387301045 creator A5006672253 @default.
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- W4387301045 creator A5091009164 @default.
- W4387301045 date "2023-10-01" @default.
- W4387301045 modified "2023-10-06" @default.
- W4387301045 title "Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells" @default.
- W4387301045 cites W1485596855 @default.
- W4387301045 cites W1493676054 @default.
- W4387301045 cites W1515564094 @default.
- W4387301045 cites W1776390480 @default.
- W4387301045 cites W1968178474 @default.
- W4387301045 cites W1970494913 @default.
- W4387301045 cites W1971042168 @default.
- W4387301045 cites W1977039417 @default.
- W4387301045 cites W1979594866 @default.
- W4387301045 cites W1980141536 @default.
- W4387301045 cites W1984567215 @default.
- W4387301045 cites W1985538633 @default.
- W4387301045 cites W1985775217 @default.
- W4387301045 cites W1988449390 @default.
- W4387301045 cites W1990000646 @default.
- W4387301045 cites W1990819855 @default.
- W4387301045 cites W1994791499 @default.
- W4387301045 cites W1995744610 @default.
- W4387301045 cites W1998921946 @default.
- W4387301045 cites W2010008322 @default.
- W4387301045 cites W2014677321 @default.
- W4387301045 cites W2015310325 @default.
- W4387301045 cites W2015776459 @default.
- W4387301045 cites W2016695100 @default.
- W4387301045 cites W2018086925 @default.
- W4387301045 cites W2026134797 @default.
- W4387301045 cites W2033169664 @default.
- W4387301045 cites W2035232303 @default.
- W4387301045 cites W2035681584 @default.
- W4387301045 cites W2040551905 @default.
- W4387301045 cites W2042183116 @default.
- W4387301045 cites W2044330780 @default.
- W4387301045 cites W2044757050 @default.
- W4387301045 cites W2051930121 @default.
- W4387301045 cites W2059332843 @default.
- W4387301045 cites W2060004514 @default.
- W4387301045 cites W2063673083 @default.
- W4387301045 cites W2064558057 @default.
- W4387301045 cites W2068511150 @default.
- W4387301045 cites W2071969437 @default.
- W4387301045 cites W2072969519 @default.
- W4387301045 cites W2085128107 @default.
- W4387301045 cites W2092629964 @default.
- W4387301045 cites W2096618637 @default.
- W4387301045 cites W2097750604 @default.
- W4387301045 cites W2099610218 @default.
- W4387301045 cites W2102619095 @default.
- W4387301045 cites W2105382508 @default.
- W4387301045 cites W2106875723 @default.
- W4387301045 cites W2112473359 @default.
- W4387301045 cites W2114111268 @default.
- W4387301045 cites W2122287804 @default.
- W4387301045 cites W2130506153 @default.
- W4387301045 cites W2140875987 @default.
- W4387301045 cites W2145200068 @default.
- W4387301045 cites W2145744908 @default.
- W4387301045 cites W2149915530 @default.
- W4387301045 cites W2152347367 @default.
- W4387301045 cites W2153466677 @default.
- W4387301045 cites W2157823450 @default.
- W4387301045 cites W2159979956 @default.
- W4387301045 cites W2166954428 @default.
- W4387301045 cites W2167073384 @default.
- W4387301045 cites W2171808845 @default.
- W4387301045 cites W2173732482 @default.
- W4387301045 cites W2175593937 @default.
- W4387301045 cites W2191790139 @default.
- W4387301045 cites W2209999571 @default.
- W4387301045 cites W2259938310 @default.
- W4387301045 cites W2300023009 @default.
- W4387301045 cites W2341539131 @default.
- W4387301045 cites W2522054472 @default.
- W4387301045 cites W2552824587 @default.
- W4387301045 cites W2553815939 @default.
- W4387301045 cites W2586653152 @default.
- W4387301045 cites W2750416916 @default.
- W4387301045 cites W2765921352 @default.
- W4387301045 cites W2766044142 @default.
- W4387301045 cites W2773964572 @default.
- W4387301045 cites W2777878934 @default.
- W4387301045 cites W2794063791 @default.
- W4387301045 cites W2795875233 @default.