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- W4387302191 abstract "Jerusalem artichoke (Helianthus tuberosus L.) is an important medicinal plant because it compose of several bioactive substances, high antioxidant activity, rich inulin content and produce functional food ingredients. Complementary alternative medicine therapies become more popular for cancer treatments because of higher efficiency, lower cost and minimum side effects. This study reported anti-cancer efficancy of both shell and tuber extract of Jerusalem artichoke (JA) on different breast cell lines with the purpose of discovering new alternative medicine therapies. Cytotoxic effects of JA was evaluated by XTT method by using different concentrations on different incubation time (24h, 48h,72h). Invasion, adhesion and apoptotic studies were performed with IC50 values for 48h and 72h. JA extracts does not show cytotoxic activity on healthy human breast cell, while they induced tumoral cell death with dose and time-dependent manner. The most effective doses of tuber and shell extracts were 108,8 µM and 134,2 µM at 48h and 20 µM ve 5 µM at 72h, respectively. It demonstrated robust anti-metastatic activity on MCF-7 cell lines because it inhibited adhesion, invasion, significantly. TMRE and AnnexinV/7AAD staining were used for determine to mitochondrial membrane potential and nuclear morphology, respectively The results were found compatible with each other. Overall, this paper which firstly in literature demonstrates the anti-cancer efficancy of the JA both tuber and shell extract which can be proposed as a potent candidate for the treatment of breast cancer." @default.
- W4387302191 created "2023-10-04" @default.
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- W4387302191 date "2023-09-28" @default.
- W4387302191 modified "2023-10-04" @default.
- W4387302191 title "Yer Elması (Helianthus tuberosus L.) Ekstraktlarının Sitotoksik, Antimetastatik ve Apoptotik Aktivitelerinin Araştırılması: MCF-7 ve MCF-12A Hücrelerinin Karşılaştırılması" @default.
- W4387302191 doi "https://doi.org/10.18016/ksutarimdoga.vi.1292478" @default.
- W4387302191 hasPublicationYear "2023" @default.
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