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• W4387302400 endingPage "14860" @default.
• W4387302400 startingPage "14860" @default.
• W4387302400 abstract "Wound healing is a complex process to restore skin. Plant-derived bioactive compounds might be a source of substances for the treatment of wounds stalled in a non-resolving stage of wound healing. Oleanolic acid (OA), a pentacyclic triterpene, has shown favorable wound healing properties both in vitro and in vivo. Unfortunately, OA cannot be solubilized in aqueous media, and it needs to be helped by the use of dimethyl sulfoxide (DMSO). In this paper, we have shown that cyclodextrins (CDs) are a good alternative to DMSO as agents to deliver OA to cells, providing better features than DMSO. Cyclodextrins are natural macromolecules that show a unique tridimensional structure that can encapsulate a wide variety of hydrophobic compounds. We have studied the cyclodextrin-encapsulated form of OA with OA/DMSO, comparing their stability, biological properties for cell migration, and cell viability. In addition, detailed parameters related to cell migration and cytoskeletal reorganization have been measured and compared. Our results show that OA-encapsulateds compound exhibit several advantages when compared to non-encapsulated OA in terms of chemical stability, migration enhancement, and preservation of cell viability." @default.
• W4387302400 created "2023-10-04" @default.
• W4387302400 creator A5004213678 @default.
• W4387302400 creator A5045424914 @default.
• W4387302400 creator A5067657518 @default.
• W4387302400 creator A5080925470 @default.
• W4387302400 date "2023-10-03" @default.
• W4387302400 modified "2023-10-18" @default.
• W4387302400 title "Oleanolic Acid Complexation with Cyclodextrins Improves Its Cell Bio-Availability and Biological Activities for Cell Migration" @default.
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