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- W4387303658 abstract "ObjectiveTo investigate whether a redistribution of water within the crystalline lens is associated with the shape deformation that occurs during accommodation.DesignObservational, cross-sectional study.SubjectsEleven young adults without presbyopia (aged 18 to 39 years) and nine middle-aged adults with presbyopia (aged 40 to 55 years).MethodsMagnetic resonance imaging (MRI) scans of the lens were acquired on a 3 Tesla clinical MRI scanner, without and with the presentation of a 3 Dioptre accommodative stimulus. MRIs were postprocessed using established methods to extract the geometric dimensions and spatial maps of water distribution of the lens.Main Outcome MeasuresAccommodative changes in the full three-dimensional description of lens shape, the lens total water distribution profile, and the lens free water distribution profile.ResultsViewing of an accommodative stimulus by young subjects elicited an elastic shape deformation of the lens consistent with accommodation that was associated with an elevated, smoother free water distribution, primarily in the anterior region of the lens. In contrast, viewing of an accommodative stimulus by presbyopic subjects produced an atypical shape deformation of the lens that was instead associated with a lowered free water distribution, also primarily in the anterior region of the lens. No discernible changes to the lens total water distribution were observed in response to the accommodative stimulus in either subject cohort.ConclusionsThe present study suggests that protein-mediated alterations in the free water distribution of the anterior region of the lens influences the shape deformation in accommodation, presenting pharmacological modulation of free water distribution as an attractive novel approach for treating presbyopia." @default.
- W4387303658 created "2023-10-04" @default.
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- W4387303658 date "2023-10-01" @default.
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- W4387303658 title "Alterations in lens free water distribution are associated with shape deformation in accommodation" @default.
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- W4387303658 doi "https://doi.org/10.1016/j.xops.2023.100404" @default.
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