Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387305840> ?p ?o ?g. }
- W4387305840 abstract "Tapeworms are parasitic flatworms that lack key features conventionally used to define the head-tail axis in free-living organisms, resulting in long standing questions regarding the true orientation of their main body axis. As adults, most tapeworms also exhibit a segmented body which has been considered an adaptation unique to the group. Anteroposterior (AP) patterning in free-living flatworms is controlled by β-catenin-dependent Wnt signalling and positional control genes are expressed by their musculature in highly regionalised domains. Here we investigate the expression of Wnt and Hedgehog components during the strobilar phase of the tapeworm life cycle during which larval tissues are lost and replaced through the continuous production of new tissues. Results reveal previously unidentified centres of signalling associated with their neuromuscular system and show that segments are marked by secondary, AP axes in agreement with the polarity of the primary body axis. Neuromuscular expression and communication between Wnt and Hedgehog signalling is consistent with embryonic and regenerative growth in planarians and is a common mechanism for establishing AP-polarised boundaries in a diverse range of segmented animals. Taken together our results suggest that segmentation in tapeworms represents a modified form of posterior regeneration, a common feature among flatworms." @default.
- W4387305840 created "2023-10-04" @default.
- W4387305840 creator A5007656292 @default.
- W4387305840 creator A5010087251 @default.
- W4387305840 creator A5020900837 @default.
- W4387305840 creator A5027053169 @default.
- W4387305840 creator A5050697870 @default.
- W4387305840 creator A5062828086 @default.
- W4387305840 date "2023-10-02" @default.
- W4387305840 modified "2023-10-10" @default.
- W4387305840 title "Segmentation in tapeworms as a modified form of flatworm posterior regeneration involving Wnt and Hedgehog signalling" @default.
- W4387305840 cites W1540483765 @default.
- W4387305840 cites W1948063975 @default.
- W4387305840 cites W1972475184 @default.
- W4387305840 cites W1975584335 @default.
- W4387305840 cites W1982377401 @default.
- W4387305840 cites W1990771698 @default.
- W4387305840 cites W2002243224 @default.
- W4387305840 cites W2006801473 @default.
- W4387305840 cites W2011040505 @default.
- W4387305840 cites W2016771776 @default.
- W4387305840 cites W2035655686 @default.
- W4387305840 cites W2042494430 @default.
- W4387305840 cites W2058632833 @default.
- W4387305840 cites W2066972948 @default.
- W4387305840 cites W2067044632 @default.
- W4387305840 cites W2068273191 @default.
- W4387305840 cites W2071708006 @default.
- W4387305840 cites W2076966904 @default.
- W4387305840 cites W2085045171 @default.
- W4387305840 cites W2088692961 @default.
- W4387305840 cites W2092414586 @default.
- W4387305840 cites W2101158284 @default.
- W4387305840 cites W2106740149 @default.
- W4387305840 cites W2123194010 @default.
- W4387305840 cites W2127315035 @default.
- W4387305840 cites W2128683321 @default.
- W4387305840 cites W2131882884 @default.
- W4387305840 cites W2136399909 @default.
- W4387305840 cites W2136550480 @default.
- W4387305840 cites W2138743768 @default.
- W4387305840 cites W2143721749 @default.
- W4387305840 cites W2145724102 @default.
- W4387305840 cites W2148257537 @default.
- W4387305840 cites W2154307309 @default.
- W4387305840 cites W2156799070 @default.
- W4387305840 cites W2161820726 @default.
- W4387305840 cites W2161833853 @default.
- W4387305840 cites W2162098634 @default.
- W4387305840 cites W2167279371 @default.
- W4387305840 cites W2232237847 @default.
- W4387305840 cites W2233956679 @default.
- W4387305840 cites W2283570988 @default.
- W4387305840 cites W2289331890 @default.
- W4387305840 cites W2290081626 @default.
- W4387305840 cites W2336730318 @default.
- W4387305840 cites W2439104830 @default.
- W4387305840 cites W2516927204 @default.
- W4387305840 cites W2553785299 @default.
- W4387305840 cites W2559577985 @default.
- W4387305840 cites W2559977074 @default.
- W4387305840 cites W2580035316 @default.
- W4387305840 cites W2607134916 @default.
- W4387305840 cites W2766862773 @default.
- W4387305840 cites W2768128882 @default.
- W4387305840 cites W2770730679 @default.
- W4387305840 cites W2780728213 @default.
- W4387305840 cites W2791943089 @default.
- W4387305840 cites W2896641154 @default.
- W4387305840 cites W2914804056 @default.
- W4387305840 cites W2932319579 @default.
- W4387305840 cites W2975932041 @default.
- W4387305840 cites W3004295003 @default.
- W4387305840 cites W3014540871 @default.
- W4387305840 cites W3082625827 @default.
- W4387305840 cites W3087648251 @default.
- W4387305840 cites W3121735591 @default.
- W4387305840 cites W4213106430 @default.
- W4387305840 cites W4386419366 @default.
- W4387305840 cites W587085497 @default.
- W4387305840 doi "https://doi.org/10.1101/2023.10.02.560491" @default.
- W4387305840 hasPublicationYear "2023" @default.
- W4387305840 type Work @default.
- W4387305840 citedByCount "0" @default.
- W4387305840 crossrefType "posted-content" @default.
- W4387305840 hasAuthorship W4387305840A5007656292 @default.
- W4387305840 hasAuthorship W4387305840A5010087251 @default.
- W4387305840 hasAuthorship W4387305840A5020900837 @default.
- W4387305840 hasAuthorship W4387305840A5027053169 @default.
- W4387305840 hasAuthorship W4387305840A5050697870 @default.
- W4387305840 hasAuthorship W4387305840A5062828086 @default.
- W4387305840 hasBestOaLocation W43873058401 @default.
- W4387305840 hasConcept C105702510 @default.
- W4387305840 hasConcept C137620995 @default.
- W4387305840 hasConcept C171056886 @default.
- W4387305840 hasConcept C2778539099 @default.
- W4387305840 hasConcept C2780516391 @default.
- W4387305840 hasConcept C2781355164 @default.
- W4387305840 hasConcept C62478195 @default.
- W4387305840 hasConcept C78458016 @default.