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• W4387305874 abstract "Abstract Lipopolysaccharide (LPS), a component of the Gram-negative bacterial cell wall, activates Toll-like receptors (TLRs). Porphyromonas gingivalis ( Pg ) may be involved in the progression of periodontal disease. Mice exposed to a novel environment show hyperlocomotion that is inhibited by systemic administration of LPS derived from Escherichia coli ( Ec -LPS). However, whether Pg -LPS influences novelty-induced locomotion is unknown. Accordingly, we carried out an open field test to analyse the effects of Pg -LPS. For comparison, effects of Ec -LPS were also studied. We also investigated the influence of systemic administration of Pg -LPS or Ec -LPS on IL-6, TNF-alpha, and IL-10 levels in blood, as they could be involved in the changes in locomotion. The TLR4 receptor antagonist TAK-242 was used to study the involvement of TLR4. Since Pg -LPS may block TLR4 in vitro , we analysed the effects of Pg -LPS on Ec -LPS-induced changes in behavioural and biochemical parameters. Male ddY mice were used. Compounds were administered intraperitoneally. Ec -LPS (840 µg/kg), but not Pg -LPS (100, 500 and 840 µg/kg), inhibited novelty-induced locomotion, which was reversed by TAK-242 (3.0 mg/kg). Ec -LPS (840 µg/kg) increased blood levels of IL-6 and IL-10, which was antagonized by TAK-242 (3.0 mg/kg). However, TAK-242 did not inhibit Ec -LPS-induced increases in TNF-alpha levels in blood. Pg -LPS (100, 500, and 840 µg/kg) did not alter blood IL-6, TNF-alpha, or IL-10 levels. The Ec -LPS-induced increase in blood IL-10, but not IL-6 and TNF-alpha, levels was inhibited by Pg -LPS (500 µg/kg). These results suggest that TLR4 stimulation mediates the inhibition of novel environment-induced locomotion in mice following systemic administration of Ec -LPS, while also increasing blood IL-6 and IL-10 levels. In contrast, Pg -LPS did not exhibit these effects. The present study also provides in vivo evidence that Pg -LPS can inhibit TLR4-mediated increases in blood IL-10 levels, which is thought to prevent the development of periodontal disease." @default.
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• W4387305874 date "2023-10-02" @default.
• W4387305874 modified "2023-10-10" @default.
• W4387305874 title "Lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: differential and interactive effects on novelty-induced hyperlocomotion, blood cytokine levels and TRL4-related processes" @default.
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• W4387305874 doi "https://doi.org/10.1101/2023.10.02.560531" @default.
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