FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387306573> ?p ?o ?g. }

• W4387306573 abstract "Tendon injuries have a high incidence and limited treatment options. Stem cell transplantation is essential for several medical conditions like tendon injuries. However, high local concentrations of reactive oxygen species (ROS) inhibit the activity of transplanted stem cells and hinder tendon repair. Cerium oxide nanoparticles (CeONPs) have emerged as antioxidant agents with reproducible reducibility.In this study, we synthesized polyethylene glycol-packed CeONPs (PEG-CeONPs), which were loaded into the human umbilical cord mesenchymal stem cells (hUCMSCs) to counteract oxidative damage. H2O2 treatment was performed to evaluate the ROS scavenging ability of PEG-CeONPs in hUCMSCs. A rat model of patellar tendon defect was established to assess the effect of PEG-CeONPs-carrying hUCMSCs in vivo. The results showed that PEG-CeONPs exhibited excellent antioxidant activity both inside and outside the hUCMSCs. PEG-CeONPs protect hUCMSCs from senescence and apoptosis under excessive oxidative stress. Transplantation of hUCMSCs loaded with PEG-CeONPs reduced ROS levels in the tendon injury area and facilitated tendon healing. Mechanistically, NFκB activator tumor necrosis factor α and MAPK activator dehydrocrenatine, reversed the therapeutic effect of PEG-CeONPs in hUCMSCs, indicating that PEG-CeONPs act by inhibiting the NFκB and MAPK signaling pathways.The carriage of the metal antioxidant oxidase PEG-CeONPs maintained the ability of hUCMSCs in the injured area, reduced the ROS levels in the microenvironment, and facilitated tendon regeneration. The data presented herein provide a novel therapeutic strategy for tendon healing and new insights into the use of stem cells for disease treatment." @default.
• W4387306573 created "2023-10-04" @default.
• W4387306573 creator A5013646893 @default.
• W4387306573 creator A5042403883 @default.
• W4387306573 creator A5073205731 @default.
• W4387306573 creator A5082974753 @default.
• W4387306573 date "2023-10-03" @default.
• W4387306573 modified "2023-10-16" @default.
• W4387306573 title "Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration" @default.
• W4387306573 cites W1886817675 @default.
• W4387306573 cites W1965045947 @default.
• W4387306573 cites W1965727192 @default.
• W4387306573 cites W1981477005 @default.
• W4387306573 cites W1985994131 @default.
• W4387306573 cites W1995286643 @default.
• W4387306573 cites W1995379479 @default.
• W4387306573 cites W2002661570 @default.
• W4387306573 cites W2011676749 @default.
• W4387306573 cites W2018777509 @default.
• W4387306573 cites W2027390314 @default.
• W4387306573 cites W2039880215 @default.
• W4387306573 cites W2047900298 @default.
• W4387306573 cites W2058650997 @default.
• W4387306573 cites W2067295210 @default.
• W4387306573 cites W2074218923 @default.
• W4387306573 cites W2084830189 @default.
• W4387306573 cites W2086324555 @default.
• W4387306573 cites W2086667809 @default.
• W4387306573 cites W2087578260 @default.
• W4387306573 cites W2089450643 @default.
• W4387306573 cites W2100693325 @default.
• W4387306573 cites W2101298045 @default.
• W4387306573 cites W2104460519 @default.
• W4387306573 cites W2106563226 @default.
• W4387306573 cites W2110639369 @default.
• W4387306573 cites W2119621864 @default.
• W4387306573 cites W2129176918 @default.
• W4387306573 cites W2144268541 @default.
• W4387306573 cites W2149300191 @default.
• W4387306573 cites W2177888210 @default.
• W4387306573 cites W2206931957 @default.
• W4387306573 cites W2310415701 @default.
• W4387306573 cites W2316999771 @default.
• W4387306573 cites W2319013688 @default.
• W4387306573 cites W2326510595 @default.
• W4387306573 cites W2336222708 @default.
• W4387306573 cites W2339856074 @default.
• W4387306573 cites W2471332471 @default.
• W4387306573 cites W2535910303 @default.
• W4387306573 cites W2582961619 @default.
• W4387306573 cites W2589307877 @default.
• W4387306573 cites W2605949967 @default.
• W4387306573 cites W2615498501 @default.
• W4387306573 cites W2624626767 @default.
• W4387306573 cites W2742007876 @default.
• W4387306573 cites W2748768502 @default.
• W4387306573 cites W2752676842 @default.
• W4387306573 cites W2756268466 @default.
• W4387306573 cites W2773409215 @default.
• W4387306573 cites W2788640168 @default.
• W4387306573 cites W2791340232 @default.
• W4387306573 cites W2800209693 @default.
• W4387306573 cites W2804246133 @default.
• W4387306573 cites W2806083865 @default.
• W4387306573 cites W2860743873 @default.
• W4387306573 cites W2896711785 @default.
• W4387306573 cites W2900505022 @default.
• W4387306573 cites W2901613071 @default.
• W4387306573 cites W2908142980 @default.
• W4387306573 cites W2911996169 @default.
• W4387306573 cites W2917284153 @default.
• W4387306573 cites W2930954504 @default.
• W4387306573 cites W2989686095 @default.
• W4387306573 cites W2990556745 @default.
• W4387306573 cites W2991550561 @default.
• W4387306573 cites W2997323331 @default.
• W4387306573 cites W3001660116 @default.
• W4387306573 cites W3003209420 @default.
• W4387306573 cites W3003901264 @default.
• W4387306573 cites W3012622455 @default.
• W4387306573 cites W3015080429 @default.
• W4387306573 cites W3083942527 @default.
• W4387306573 cites W3087018315 @default.
• W4387306573 cites W3109310957 @default.
• W4387306573 cites W3129038148 @default.
• W4387306573 cites W3138805106 @default.
• W4387306573 cites W3157365639 @default.
• W4387306573 cites W3165554758 @default.
• W4387306573 cites W3175946098 @default.
• W4387306573 cites W3211766605 @default.
• W4387306573 cites W4221053915 @default.
• W4387306573 cites W4280535603 @default.
• W4387306573 cites W4295346588 @default.
• W4387306573 cites W4319656164 @default.
• W4387306573 cites W4321004232 @default.
• W4387306573 cites W4321786896 @default.
• W4387306573 cites W4363650813 @default.
• W4387306573 cites W4377246835 @default.
• W4387306573 cites W4380792986 @default.
• W4387306573 doi "https://doi.org/10.1186/s12951-023-02125-5" @default.

• next