Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387306750> ?p ?o ?g. }
- W4387306750 abstract "Experimental studies in animal models of aging such as nematodes, fruit flies or mice have observed that decreased levels of insulin or insulin signaling promotes longevity. In humans, hyperinsulinemia and concomitant insulin resistance are associated with an elevated risk of age-related diseases suggestive of a shortened healthspan. Age-related disorders include neurodegenerative diseases, hypertension, cardiovascular disease, and type 2 diabetes. High ambient insulin concentrations promote increased lipogenesis and fat storage, heightened protein synthesis and accumulation of non-functional polypeptides due to limited turnover capacity. Moreover, there is impaired autophagy activity, and less endothelial NO synthase activity. These changes are associated with mitochondrial dysfunction and oxidative stress. The cellular stress induced by anabolic activity of insulin initiates an adaptive response aiming at maintaining homeostasis, characterized by activation of the transcription factor Nrf2, of AMP activated kinase, and an unfolded protein response. This protective response is more potent in the long-lived human species than in short-lived models of aging research resulting in a stronger pro-aging impact of insulin in nematodes and fruit flies. In humans, resistance to insulin-induced cell stress decreases with age, because of an increase of insulin and insulin resistance levels but less Nrf2 activation. These detrimental changes might be contained by adopting a lifestyle that promotes low insulin/insulin resistance levels and enhances an adaptive response to cellular stress, as observed with dietary restriction or exercise." @default.
- W4387306750 created "2023-10-04" @default.
- W4387306750 creator A5048979097 @default.
- W4387306750 creator A5063032422 @default.
- W4387306750 creator A5090127748 @default.
- W4387306750 date "2023-10-03" @default.
- W4387306750 modified "2023-10-05" @default.
- W4387306750 title "Insulin and aging – a disappointing relationship" @default.
- W4387306750 cites W1540734092 @default.
- W4387306750 cites W1792680009 @default.
- W4387306750 cites W1877024927 @default.
- W4387306750 cites W1938310987 @default.
- W4387306750 cites W1964779097 @default.
- W4387306750 cites W1966537913 @default.
- W4387306750 cites W1967083598 @default.
- W4387306750 cites W1971473302 @default.
- W4387306750 cites W1977128714 @default.
- W4387306750 cites W1979000812 @default.
- W4387306750 cites W1980442558 @default.
- W4387306750 cites W1980928521 @default.
- W4387306750 cites W1985425785 @default.
- W4387306750 cites W1986795114 @default.
- W4387306750 cites W1989616776 @default.
- W4387306750 cites W1992444358 @default.
- W4387306750 cites W2001093010 @default.
- W4387306750 cites W2012645958 @default.
- W4387306750 cites W2013567290 @default.
- W4387306750 cites W2014440105 @default.
- W4387306750 cites W2025197166 @default.
- W4387306750 cites W2029084853 @default.
- W4387306750 cites W2029626642 @default.
- W4387306750 cites W2033797333 @default.
- W4387306750 cites W2036506653 @default.
- W4387306750 cites W2041318391 @default.
- W4387306750 cites W2046989794 @default.
- W4387306750 cites W2052722944 @default.
- W4387306750 cites W2055708395 @default.
- W4387306750 cites W2057913302 @default.
- W4387306750 cites W2058803994 @default.
- W4387306750 cites W2060098417 @default.
- W4387306750 cites W2060975420 @default.
- W4387306750 cites W2066519654 @default.
- W4387306750 cites W2067623665 @default.
- W4387306750 cites W2069988949 @default.
- W4387306750 cites W2070559169 @default.
- W4387306750 cites W2073636233 @default.
- W4387306750 cites W2074240564 @default.
- W4387306750 cites W2078268440 @default.
- W4387306750 cites W2079916975 @default.
- W4387306750 cites W2084212130 @default.
- W4387306750 cites W2093563309 @default.
- W4387306750 cites W2112523282 @default.
- W4387306750 cites W2112672163 @default.
- W4387306750 cites W2114764690 @default.
- W4387306750 cites W2119057118 @default.
- W4387306750 cites W2119764874 @default.
- W4387306750 cites W2119788948 @default.
- W4387306750 cites W2122857181 @default.
- W4387306750 cites W2127283831 @default.
- W4387306750 cites W2127696787 @default.
- W4387306750 cites W2128737667 @default.
- W4387306750 cites W2143264382 @default.
- W4387306750 cites W2143366257 @default.
- W4387306750 cites W2143536481 @default.
- W4387306750 cites W2144810749 @default.
- W4387306750 cites W2148293249 @default.
- W4387306750 cites W2149098481 @default.
- W4387306750 cites W2151427219 @default.
- W4387306750 cites W2152990151 @default.
- W4387306750 cites W2153607816 @default.
- W4387306750 cites W2168798429 @default.
- W4387306750 cites W2171843668 @default.
- W4387306750 cites W2261796080 @default.
- W4387306750 cites W2273582840 @default.
- W4387306750 cites W2308350549 @default.
- W4387306750 cites W2319845284 @default.
- W4387306750 cites W2330049470 @default.
- W4387306750 cites W2332816518 @default.
- W4387306750 cites W2347107523 @default.
- W4387306750 cites W2361181847 @default.
- W4387306750 cites W2400239628 @default.
- W4387306750 cites W2406168867 @default.
- W4387306750 cites W2513613066 @default.
- W4387306750 cites W2528242093 @default.
- W4387306750 cites W2532167704 @default.
- W4387306750 cites W2542468576 @default.
- W4387306750 cites W2554192146 @default.
- W4387306750 cites W2560373668 @default.
- W4387306750 cites W2588346480 @default.
- W4387306750 cites W2595793016 @default.
- W4387306750 cites W2735941788 @default.
- W4387306750 cites W2756021596 @default.
- W4387306750 cites W2763871199 @default.
- W4387306750 cites W2767332403 @default.
- W4387306750 cites W2775143558 @default.
- W4387306750 cites W2782327453 @default.
- W4387306750 cites W2796559433 @default.
- W4387306750 cites W2809270825 @default.
- W4387306750 cites W2884081989 @default.
- W4387306750 cites W2894123970 @default.