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• W4387307102 startingPage "113188" @default.
• W4387307102 abstract "The melanocortin-3 receptor (MC3R) is a negative regulator of the central melanocortin circuitry via presynaptic expression on agouti-related protein (AgRP) nerve terminals, from where it regulates GABA release onto secondary MC4R-expressing neurons. However, MC3R knockout (KO) mice also exhibit defective behavioral and neuroendocrine responses to fasting. Here, we demonstrate that MC3R KO mice exhibit defective activation of AgRP neurons in response to fasting, cold exposure, or ghrelin while exhibiting normal inhibition of AgRP neurons by sensory detection of food in the ad libitum-fed state. Using a conditional MC3R KO model, we show that the control of AgRP neuron activation by fasting and ghrelin requires the specific presence of MC3R within AgRP neurons. Thus, MC3R is a crucial player in the responsiveness of the AgRP soma to both hormonal and neuronal signals of energy need." @default.
• W4387307102 created "2023-10-04" @default.
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• W4387307102 date "2023-10-01" @default.
• W4387307102 modified "2023-10-16" @default.
• W4387307102 title "Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency" @default.
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• W4387307102 doi "https://doi.org/10.1016/j.celrep.2023.113188" @default.
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• W4387307102 hasPublicationYear "2023" @default.
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