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• W4387307838 abstract "SignificanceStudying cerebral hemodynamics may provide diagnostic information on neurological conditions. Wide-field imaging techniques, such as laser speckle imaging (LSI) and optical intrinsic signal imaging, are commonly used to study cerebral hemodynamics. However, they often do not account appropriately for the optical properties of the brain that can vary among subjects and even during a single measurement. Here, we describe the combination of LSI and spatial-frequency domain imaging (SFDI) into a wide-field quantitative hemodynamic imaging (QHI) system that can correct the effects of optical properties on LSI measurements to achieve a quantitative measurement of cerebral blood flow (CBF).AimWe describe the design, fabrication, and testing of QHI.ApproachThe QHI hardware combines LSI and SFDI with spatial and temporal synchronization. We characterized system sensitivity, accuracy, and precision with tissue-mimicking phantoms. With SFDI optical property measurements, we describe a method derived from dynamic light scattering to obtain absolute CBF values from LSI and SFDI measurements. We illustrate the potential benefits of absolute CBF measurements in resting-state and dynamic experiments.ResultsQHI achieved a 50-Hz raw acquisition frame rate with a 10 × 10 mm field of view and flow sensitivity up to ∼4 mm / s. The extracted SFDI optical properties agreed well with a commercial system (R2 ≥ 0.98). The system showed high stability with low coefficients of variations over multiple sessions within the same day (<1 % ) and over multiple days (<4 % ). When optical properties were considered, the in-vivo hypercapnia gas challenge showed a slight difference in CBF (−1.5 % to 0.5% difference). The in-vivo resting-state experiment showed a change in CBF ranking for nine out of 13 animals when the correction method was applied to LSI CBF measurements.ConclusionsWe developed a wide-field QHI system to account for the confounding effects of optical properties on CBF LSI measurements using the information obtained from SFDI." @default.
• W4387307838 created "2023-10-04" @default.
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• W4387307838 date "2023-10-03" @default.
• W4387307838 modified "2023-10-11" @default.
• W4387307838 title "Quantitative hemodynamic imaging: a method to correct the effects of optical properties on laser speckle imaging" @default.
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• W4387307838 doi "https://doi.org/10.1117/1.nph.10.4.045001" @default.
• W4387307838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37795105" @default.
• W4387307838 hasPublicationYear "2023" @default.
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