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• W4387308712 abstract "Abstract Aim This study investigated the changes in brain gray and white matter structure in SMA patients and their correlation with the severity of the disease. Method A total of 43 SMA patients (including 22 type II and 21 type III SMA patients) and 37 healthy controls were evaluated by MRI. The grey matter volume, grey matter thickness, grey matter surface area, and white matter volume of designated brain regions automatically segmented by FreeSurfer, were compared. We evaluate clinical characteristics of SMA and study the correlation between clinical characteristics and structural changes. Results SMA showed significant bilateral cortical superficial area loss in the frontal, parietal, and temporal lobes and global white matter volume decreases. Moreover, these patients were also found with an increased mean thickness of entire brain and right grey matter. An increased right postcentral gyrus superficial area, right central sulcus volume, and white matter volume of the right postcentral were associated with higher HFMSE scores. Interpretation: Type 2 and 3 children SMA had extensive, multifocal, symmetrical gray and white matter alterations. Postcentral gyrus degeneration of SMA was associated with the severity of muscular atrophy. The lack of SMN protein possibly interacted with cerebellar structural changes in somatosensory areas." @default.
• W4387308712 created "2023-10-04" @default.
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• W4387308712 date "2023-10-03" @default.
• W4387308712 modified "2023-10-05" @default.
• W4387308712 title "Grey and white matter abnormalities in children with type 2 and 3 SMA: A morphological assessment" @default.
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• W4387308712 doi "https://doi.org/10.21203/rs.3.rs-3385077/v1" @default.
• W4387308712 hasPublicationYear "2023" @default.
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