FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387312631> ?p ?o ?g. }

• W4387312631 endingPage "e200200" @default.
• W4387312631 startingPage "e200200" @default.
• W4387312631 abstract "Background and Objectives Social and structural determinants of health (SDOH) have been associated with disability in neurologic diseases. However, the association between these factors and disability in Huntington disease (HD) has not been studied. This study aimed to evaluate the association of racial and sociodemographic factors with disease severity in patients with HD in North America. Methods We conducted a cross-sectional study of genetically confirmed participants with HD (36+ CAG repeats) in the North American region using the ENROLL-HD 2020 periodic dataset. In this analysis, our exposure variable was the participant's race/ethnicity. The main outcome measure was disease severity, as measured by the Total Functional Capacity Score (TFC), which measures the level of disability of patients with HD. We used multivariate regression models to adjust for sociodemographic factors that may mediate or moderate a causal effect between race/ethnicity and disease severity. Results Among 4,717 gene-positive participants in the North American region, 89.5% identified as White, 3.4% as Hispanic or Latino, and 2.3% as African American/Black. The average TFC score was 10.22 (SD 3.22); 48% of participants completed either secondary education (including college) or a professional degree, and 55% lived in a city and not in a town, village, or rural location. In multivariate regression models, we found that Black participants and those with less than a high school degree entered the ENROLL-HD study with lower TFC scores than White participants. We also found that compared with those with at least a high school degree, those who completed some form of higher education or professional degree had higher TFC scores ( p < 0.001). This multivariate analysis did not find an association between geographic location and TFC score. Discussion Our study found that Black participants in North America presented to ENROLL-HD with more advanced disease than White patients. We also found that higher education was associated with less advanced disease when entering the ENROLL-HD study. The role of race/ethnicity and education in HD symptom severity warrants further investigation. These findings underscore the importance of further studying the role of social and structural determinants of health in patients with HD, particularly those from historically marginalized communities." @default.
• W4387312631 created "2023-10-04" @default.
• W4387312631 creator A5045611515 @default.
• W4387312631 creator A5049125090 @default.
• W4387312631 creator A5065516635 @default.
• W4387312631 creator A5088753130 @default.
• W4387312631 creator A5091346458 @default.
• W4387312631 date "2023-10-03" @default.
• W4387312631 modified "2023-10-16" @default.
• W4387312631 title "Disparities in Huntington Disease Severity" @default.
• W4387312631 cites W1973433476 @default.
• W4387312631 cites W2017946173 @default.
• W4387312631 cites W2055962836 @default.
• W4387312631 cites W2064546274 @default.
• W4387312631 cites W2075765029 @default.
• W4387312631 cites W2100549834 @default.
• W4387312631 cites W2126160304 @default.
• W4387312631 cites W2127571714 @default.
• W4387312631 cites W2144204711 @default.
• W4387312631 cites W2260359893 @default.
• W4387312631 cites W2462093517 @default.
• W4387312631 cites W2466242214 @default.
• W4387312631 cites W2606710341 @default.
• W4387312631 cites W2611737256 @default.
• W4387312631 cites W2616393094 @default.
• W4387312631 cites W2633550421 @default.
• W4387312631 cites W2756482995 @default.
• W4387312631 cites W2766846776 @default.
• W4387312631 cites W2786505295 @default.
• W4387312631 cites W2915744129 @default.
• W4387312631 cites W2922012840 @default.
• W4387312631 cites W2955386528 @default.
• W4387312631 cites W2970082498 @default.
• W4387312631 cites W3097301523 @default.
• W4387312631 cites W3113226900 @default.
• W4387312631 cites W3115440320 @default.
• W4387312631 cites W3133496610 @default.
• W4387312631 cites W3136008922 @default.
• W4387312631 cites W3138778966 @default.
• W4387312631 cites W3164113617 @default.
• W4387312631 cites W31801189 @default.
• W4387312631 cites W3215097377 @default.
• W4387312631 cites W4210460859 @default.
• W4387312631 cites W4226350832 @default.
• W4387312631 cites W4240676061 @default.
• W4387312631 cites W4282979939 @default.
• W4387312631 cites W4306195279 @default.
• W4387312631 doi "https://doi.org/10.1212/cpj.0000000000200200" @default.
• W4387312631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37795504" @default.
• W4387312631 hasPublicationYear "2023" @default.
• W4387312631 type Work @default.
• W4387312631 citedByCount "0" @default.
• W4387312631 crossrefType "journal-article" @default.
• W4387312631 hasAuthorship W4387312631A5045611515 @default.
• W4387312631 hasAuthorship W4387312631A5049125090 @default.
• W4387312631 hasAuthorship W4387312631A5065516635 @default.
• W4387312631 hasAuthorship W4387312631A5088753130 @default.
• W4387312631 hasAuthorship W4387312631A5091346458 @default.
• W4387312631 hasConcept C105795698 @default.
• W4387312631 hasConcept C126322002 @default.
• W4387312631 hasConcept C137403100 @default.
• W4387312631 hasConcept C142052008 @default.
• W4387312631 hasConcept C142724271 @default.
• W4387312631 hasConcept C144024400 @default.
• W4387312631 hasConcept C149923435 @default.
• W4387312631 hasConcept C15744967 @default.
• W4387312631 hasConcept C161584116 @default.
• W4387312631 hasConcept C19165224 @default.
• W4387312631 hasConcept C2779134260 @default.
• W4387312631 hasConcept C2780647506 @default.
• W4387312631 hasConcept C33923547 @default.
• W4387312631 hasConcept C38180746 @default.
• W4387312631 hasConcept C59822182 @default.
• W4387312631 hasConcept C71924100 @default.
• W4387312631 hasConcept C74909509 @default.
• W4387312631 hasConcept C76509639 @default.
• W4387312631 hasConcept C86803240 @default.
• W4387312631 hasConceptScore W4387312631C105795698 @default.
• W4387312631 hasConceptScore W4387312631C126322002 @default.
• W4387312631 hasConceptScore W4387312631C137403100 @default.
• W4387312631 hasConceptScore W4387312631C142052008 @default.
• W4387312631 hasConceptScore W4387312631C142724271 @default.
• W4387312631 hasConceptScore W4387312631C144024400 @default.
• W4387312631 hasConceptScore W4387312631C149923435 @default.
• W4387312631 hasConceptScore W4387312631C15744967 @default.
• W4387312631 hasConceptScore W4387312631C161584116 @default.
• W4387312631 hasConceptScore W4387312631C19165224 @default.
• W4387312631 hasConceptScore W4387312631C2779134260 @default.
• W4387312631 hasConceptScore W4387312631C2780647506 @default.
• W4387312631 hasConceptScore W4387312631C33923547 @default.
• W4387312631 hasConceptScore W4387312631C38180746 @default.
• W4387312631 hasConceptScore W4387312631C59822182 @default.
• W4387312631 hasConceptScore W4387312631C71924100 @default.
• W4387312631 hasConceptScore W4387312631C74909509 @default.
• W4387312631 hasConceptScore W4387312631C76509639 @default.
• W4387312631 hasConceptScore W4387312631C86803240 @default.
• W4387312631 hasIssue "6" @default.
• W4387312631 hasLocation W43873126311 @default.

• next