Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387312905> ?p ?o ?g. }
- W4387312905 abstract "Abstract Respiratory infections pose a global health crisis. Vaccines are pathogen specific, and new vaccines are needed for mutants and emerging pathogens. Here, we report a “drug free” prophylactic platform - a “Pathogen Capture and Neutralizing Spray” (PCANS) that acts via a multi-pronged approach to prevent a broad spectrum of respiratory infections. PCANS forms a protective coating in the nasal cavity that enhances the capture of large respiratory droplets. The coating acts as a physical barrier against a broad spectrum of viruses and bacteria, and rapidly neutralizes them, reducing the pathogen load by >99.99%. In mice, PCANS showed nasal retention for at least 8 h and was safe for daily administration. A single prophylactic dose of PCANS protected mice against supra-lethal dosages of a mouse-adapted H1N1 Influenza virus (PR8), reduced lung viral titer by >99.99%, improved survival, and suppressed pathological manifestations. Together, our data suggest PCANS as a promising daily-use prophylactic approach against current and emerging respiratory infections." @default.
- W4387312905 created "2023-10-04" @default.
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- W4387312905 date "2023-10-03" @default.
- W4387312905 modified "2023-10-11" @default.
- W4387312905 title "A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections" @default.
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- W4387312905 doi "https://doi.org/10.1101/2023.10.02.560602" @default.
- W4387312905 hasPublicationYear "2023" @default.
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